HIV-1 Integrase Structures Index
Tutorials and Museum Exhibits
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A tutorial on HIV-1 Integrase structure/function was done by Maggie Somple, Nathan Silva, and David Marcey from the Online Macromolecular Museum at California Lutheran University.
HIV Integrase Review in EMBO J
(see 1K6Y structure below)
Wang JY, Ling H, Yang W, Craigie R.
Structure of a two-domain fragment of HIV-1 integrase:
implications for domain organization in the intact protein.
EMBO J 2001 Dec 17;20(24):7333-43
PMID: 11743009
or
(PDF file
download)
PDB Structure Entries
Use the buttons below each entry in the list to get the PubMed entry, protein structure database (PDB) entry, open a Protein Explorer session with the entry, or get the NCBI entry (allowing Cn3D viewing) of the entry.- 1K6Y: EMBO J 2001 Dec 17;20(24):7333-43.
- HIV-1 Integrase (AA 1-288) tetramer with potassium, phosphate and
zinc bound.
- 1EX4: Proc Natl Acad Sci U S A 2000 Jul 18;97(15):8233-8.
- HIV-1 Integrase Catalytic Core and C-Terminal Domains (AA 50-288).
- 1C6V4: J Mol Biol 2000 Feb 18;296(2):521-33.
- Simian Immunodeficiency Virus Integrase Catalytic Core and C-Terminal
Domains (tetramer of AA 50-213 in SIV-MAC239; 50-216 in HXB2: plus monomer
of AA 213-293 SIV-MAC239; 213-288 HXB2).
- 1IHV: Biochemistry 1995 Aug 8;34(31):9826-33.
- HIV-1 Integrase Carboxy-terminal DNA binding domain (AA 219-270):
40 NMR structures.
- 1WJA: Nat Struct Biol 1997 Jul;4(7):567-77.
- HIV-1 Integrase Amino-terminal Zinc binding domain (AA 1-47)
with zinc bound: 40 NMR structures.
- 1BL3: J Mol Biol 1998 Sep 18;282(2):359-68.
- HIV-1 Integrase central catalytic domain (AA 50-209) with magnesium
bound: 40 NMR structures.
Related Structures
- 1C0M: J Mol Biol 1998 Sep 18;282(2):359-68.
- Crystal structure of Rous Sarcoma Virus two-domain integrase.
Publications on Integrase Structures
Drug Resistance Mutations
Barreca ML, Lee KW, Chimirri A, Briggs JM.
Molecular Dynamics Studies of the Wild-Type and Double Mutant HIV-1 Integrase
Complexed with the 5CITEP Inhibitor: Mechanism for Inhibition and Drug Resistance.
Biophys J. 2003 Mar;84(3):1450-63.
PMID: 12609852
HIV-2 Zinc-binding domain
Feiters MC, Eijkelenboom AP, Nolting HF, Krebs B,
van den Ent FM, Plasterk RH, Kaptein R, Boelens R.
X-ray absorption spectroscopic studies of zinc in the N-terminal
domain of HIV-2 integrase and model compounds.
J Synchrotron Radiat. 2003 Jan 1;10(Pt 1):86-95.
PMID: 12511797
Integrase may form tetramers or octamers.
Cherepanov P, Maertens G, Proost P, Devreese B,
Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z.
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75
protein in human cells.
J Biol Chem. 2003 Jan 3;278(1):372-81.
PMID: 12407101
EBR28 a peptide inhibitor of Integrase.
de Soultrait VR, Caumont A, Parissi V, Morellet N, Ventura M,
Lenoir C, Litvak S, Fournier M, Roques B.
A novel short peptide is a specific inhibitor of the human immunodeficiency
virus type 1 integrase.
J Mol Biol. 2002 Apr 19;318(1):45-58.
PMID: 12054767
Human Rad18 DNA damage/repair enzyme stabilizes HIV Integrase.
Mulder LC, Chakrabarti LA, Muesing MA.
Interaction of HIV-1 integrase with DNA repair protein hRad18.
J Biol Chem. 2002 Jul 26;277(30):27489-93.
PMID: 12016221
