HIV Databases HIV Databases home HIV Databases home
HIV sequence database



KEY FOR SIV CORECEPTOR TABLE

SIV strains are also rather promiscuous in their use of coreceptors. SIV strains use CCR5 with few exceptions, while CXCR4 is only rarely used, even by laboratory-adapted viruses, a feature that distinguishes them from HIV-1 strains. The Table indicates the tropism of the virus (when known) as well as whether the data were derived from a molecular clone or virus swarm.

a Isolates shown to be capable of CD4-independent cell fusion and/or virus infection

S = uncloned virus swarm

MC = molecular clone

M = macrophage tropic, Md = delayed infection kinetics in macrophages, (M) = probably M-tropic, T = T-tropic

( ) indicate fusion results, all other data from infection assays

Strain

Accession

Status

Tropism

Coreceptors

CD4 independencea

References

SIVmac251

U62334

S

M

CCR5/\-GPR15/\-STRL33

Chen97,Chen98a,Kuhmann97,Luciw92

SIVmac251 (BK28 clone)

MC

CCR5/\-GPR15/\-STRL33/\-GPR1

Edinger97b,Edinger99a

SIVmac251 (v194 clone)

MC

(CCR5/\-STRL33/\-GPR1/\-GPR15)

Rucker97,Edinger97a,Edinger97b,Koenig89

SIVmac239

M33262

MC

T

CCR5/\-STRL33/\-GPR15/\-GPR1/\-(ChemR23)

Edinger97a,Edinger97b,Edinger99a,Choe98,Rucker97,Chen97,Chen98a,Hill97,Hill98,Kirchhoff97,Marcon97,Samson98,Farzan97,Deng97

SIVmac316

MC

M

CCR5/\-STRL33/\-GPR15/\-APJ/\-CCR8/\-GPR1/\-(ChemR23)

+

Edinger97a,Edinger97b,Choe98,Rucker97,Kirchhoff97,Samson98,Farzan97

SIVmac316mut

MC

Md

CCR5/\-(STRL33/\-GPR1/\-GPR15/\-ChemR23/\-APJ)

Edinger97a,Edinger97b,Edinger98b,Rucker97,Kirchhoff97,Kirchhoff94,Samson98

SIVmac316EM

MC

M

CCR5/\-GPR15/\-STRL33

Chen97,Chen98a

SIVmac32H

CCR5, CCR1, gpr15, STRL33

+

Reeves99

SIVmac1A11

MC

M

CCR5/\-STRL33/\-GPR15

Edinger97b,Edinger99a,Chen97,Chen98a,Hill97,Banapour91a,Banapour91b,Deng97,Chen98a,Chen98b

SIVmac/\-17E-Fr

MC

M

CCR5/\-STRL33/\-GPR15/\-APJ/\-(ChemR23/\-CCR8)

+

Edinger97a,Edinger97b,Edinger98b,Edinger99a,Rucker97,Flaherty97

SIVmac/\-17E-Cl

MC

M

(CCR5/\-GPR1/\-STRL33/\-GPR15)

Edinger98a,Flaherty97

SIVmacCP-MAC

S

CXCR4

Endres96

SIVmacCP-MAC

MC

CCR5/\-STRL33/\-GPR15/\-APJ

Edinger97b,Edinger98b,Edinger99a

SIVmac(mne)

CCR5/\-GPR15

Chen98a

SIVsm$\Delta$B670 clone 3

MC

CCR5/\-GPR15/\-STRL33

+

Edinger97a,Edinger97b,Rucker97

SIVsm$\Delta$B670 clone 12

MC

(M)

CCR5/\-GPR15

+

Edinger97b,Edinger99a,Amedee95

SIVsm62A

MC

T

(CCR5/\-GPR1/\-GPR15/\-STRL33/\-ChemR23)

+

Edinger97b,Hirsch94

SIVsm62B

SIU04983

MC

(CCR5)

+

Edinger97b,Hirsch94

SIVsm62D

SIU04987

MC

M

CCR5

Edinger97b,Hirsch94

SIVsmE543/\-3

MC

M

CCR5/\-GPR15

Edinger97b,Hirsch97

SIVsmE543/\-B10

MC

(CCR5/\-GPR15/\-GPR1/\-STRL33)

Edinger97b,Hirsch97

SIVsmPBj6.6

MC

(STRL33/\-CCR5/\-GPR1/\-GPR15)

Edinger98a,Novembre93

SIVsmSL92a

U48818

S

CCR5/\-GPR15/\-STRL33

Chen97,Chen98a

SIVsmSL92b

U48819

S

CCR5/\-GPR15/\-STRL33

Chen98a

SIVsmLib-1

U48824

S

CCR5/\-GPR15/\-STRL33

Chen97,Chen98a

SIVsmFNS

S

CCR5/\-GPR15/\-STRL33

Chen98a

SIVagmSab1.4

MC

(CCR5/\-GPR15/\-GPR1/\-STRL33)

Edinger97b

SIVagm9063-2

MC

M

(CCR5)

Edinger97b,Hirsch95

SIVagmTYO

X07805

MC

CCR5/\-GPR15/\-STRL33

Deng97,Chen98a,Chen98b

SIVmneCl8

MC

CCR5

Chackerian97

SIVrcm

CCR2b/\-STRL33

Marx98

SIVcpzGAB

X52154

S

CCR5

Chen97,Marx98

SIVmnd(GB-1)

S

CXCR4

Schols98

last modified: Fri Aug 10 14:02 2007


Questions or comments? Contact us at seq-info@lanl.gov.

 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2005-2012 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health