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KEY FOR HIV-2 CORECEPTOR USE TABLE

HIV-2 strains appear to be remarkably promiscuous in their use of coreceptors, with receptors other than CCR5 or CXCR4 often supporting very efficient virus infection in transfected cells. This is obvious from the table, where coreceptors that are used efficiently are listed separately from those that support infection inefficiently. In addition, whenever possible, information is provided about the virus (whether it is a molecular clone, biological clone, or virus swarm, and whether it can infect PBMCs from CCR5-negative individuals) and the clinical stage of the patient from which each virus was isolated.

a Delta 32 PBMCs Replication

b Isolates shown to be capable of CD4-independent cell fusion and/or virus infection

MC = molecular clone

BC = biologic clone

S = virus swarm

ASYMP = asymptomatic

SYMP = symptomatic

DONOR = blood donor

EARLY = isolated at early timepoints

INTERMED = isolated at an intermediate point in disease progression

LATE = isolated late in disease

V28 has been redesignated CX3CR1

( ) indicates results are from cell-cell fusion assays, all other data are from infection assays

Isolate

Proposed Accession

Status

Primary Isolate?

Delta 32a

Patient Status

Coreceptors

Weak Coreceptors

CD-4 Independenceb

References

ST

MC

NO

+

ASYMP

CCR5/\-GPR15/\-STRL33(GPR1/\-APJ)

CCR1/\-CCR2b/\-CCR3/\-CXCR4

Edinger97b,Edinger98a,Edinger98b,Rucker97,Hill97,McKnight98,Deng97

ST/\-24.1C\#2

M86924

MC

CCR5/\-GPR15/\-STRL33

Rucker97,Hill97,Hill98,Deng97

SBL6669

J04498

MC

SYMP

(CCR5/\-CXCR4/\-CCR8/\-V28)

Rucker97,Chakrabarti90,Albert87

ROD/\-A

\box\fixbox

MC

AIDS

CCR5/\-CXCR4/\-CCR3/\-US28/\-V28

+

Hill97,Sol98,Sol97,Clavel86,Bron97,Reeves97,Reeves99

ROD/\-B

MC

NO

CXCR4

CCR3/\-V28

+

Clapham92,Reeves97,Reeves99

prCBL-20

MC

YES

+

AIDS

CXCR4

CCR1/\-CCR2b/\- CCR3/\-CCR5

McKnight98,Schulz90

CBL-20

MC

NO

+

CXCR4

McKnight98

prCBL-23

U05352

MC

YES

SYMP

CXCR4

CCR1/\-CCR2b/\-CCR3/\-CCR5

McKnight98,Schulz90

UC1

L0965

MC

SYMP

CCR5

Hill97,Evans88,Deng97

UC2

U38293

MC

NO

AIDS

CCR5/\-CXCR4/\-STRL33/\-GPR15

CCR2b/\-CCR3

Hill97,Evans88,Barnett96,Deng97

MIR

MC

+

AIDS

CXCR4

CCR1/\-CCR2b/\-CCR3/\-CCR5

Sol97,McKnight98,Clavel86

V9

AIDS

CCR1/\-CCR2b/\-CCR3/\-CCR5/\-CXCR4

McKnight98

A-ND

+

SYMP

CXCR4

CCR1/\-CCR2b/\-CCR3

McKnight98

VCP

MC

NO

CXCR4

Endres96

F0784

L33083

MC

CCR5/\-GPR15

Deng97,Gao92

A195811

YES

-

AIDS

CCR5/\-GPR15/\-STRL33

Chen98a,Owen98

A227011

YES

-

ASYMP

CCR5/\-GPR15/\-STRL33

Chen98a

G0415k

YES

CCR5/\-GPR15/\-STRL33

Chen98a

7924A

YES

+

AIDS

CXCR4/\-CCR2b/\-CCR3/\-CCR5/\-STRL33/\-GPR15

Chen98a

JK7312A

MC

+

SYMP

CCR5/\-GPR15/\-CCR4/\-CXCR4

Hill97,Owen98,Gao92,Deng97

310342

S

YES

CCR5/\-CXCR4/\-STRL33/\-CCR1

Owen98

GB87

S

YES

+

SYMP

CCR5/\-GPR15/\-CXCR4/\-STRL33/\-CCR4/\-CCR2b/\-CCR1

Owen98

310248

S

YES

+

CCR1/\-CCR4/\-CCR5/\-CXCR4

Owen98

310319

S

YES

+

CCR2b/\-CCR3/\-CCR4/\-CXCR4/\-STRL33/\-GPR15/\-CCR5

Owen98

77618

S

YES

+

AIDS

CCR2b/\-CCR3/\-CXCR4/\-GPR15/\-STRL33/\-CCR5

Owen98

GB122

L10638

S

YES

+

CCR2b/\-CCR3/\-GPR15

CCR5/\-CXCR4

Owen98

A2267

S

YES

-

ASYMP

CCR5

Owen98

SLRHC

S

YES

-

ASYMP

CCR5

Owen98

310072

S

YES

-

DONOR

CCR5

Owen98

310340

S

YES

-

DONOR

CCR5

Owen98

60415k

S

YES

-

ASYMP

CCR5

Owen98

BAJE (B)

S

YES

-

ASYMP

CCR5/\-CCR3

Sol98

BATI (A)

S

YES

-

ASYMP

CCR5

CCR3

Sol97

BAPA (C)

S

YES

+

ASYMP

CCR5

CCR3

Sol97

DESY (E)

S

YES

ASYMP

CCR5

CCR3

Sol97

BAYO (G)

S

YES

+

AIDS

CXCR4

Sol97

B3

S

YES

CCR5

Heredia97

B4

S

YES

CCR5

Heredia97

B7

S

YES

CCR5

Heredia97

B8

S

YES

CCR5

Heredia97

B9

S

YES

CCR5

Heredia97

B2

S

YES

CCR1/\-CCR2b/\-CCR5/\-CXCR4

Heredia97

B5

S

YES

CCR1/\-CCR2b/\-CCR5/\-CXCR4

Heredia97

B10

S

YES

CCR1/\-CCR2b/\-CCR5/\-CXCR4

Heredia97

RH-2-1

S

YES

EARLY

CCR5

Guillon98

PH-2-1 C1

BC

YES

INTERMED

CCR5

Guillon98

PH-2-1 C12

BC

YES

INTERMED

CCR5/\-CCR1/\-CCR3

Guillon98

PH-2-1 E6

BC

YES

INTERMED

CCR5/\-CXCR4/\-CCR3/\-CCR1

Guillon98

PH-2-1 H8

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

Guillon98

PH-2-1 D5

BC

YES

INTERMED

CCR5

CCR3/\-CXCR4/\-CCR1

Guillon98

PH-2-1 H12

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

CXCR4

Guillon98

RH-2-5 A10

BC

YES

INTERMED

CCR5

CCR3

Guillon98

RH-2-5 E4

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

CXCR4

Guillon98

RH-2-5 E11

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

CXCR4

Guillon98

RH-2-5 F7

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1/\-CXCR4

Guillon98

RH-2-5 G7

BC

YES

INTERMED

CCR5

CXCR4/\-CCR1/\-CCR3

Guillon98

RH-2-7 A5

BC

YES

INTERMED

CCR5/\-CCR3

CCR1/\-CXCR4

Guillon98

RH-2-7 C9

BC

YES

INTERMED

CCR5/\-CCR1/\-CCR3/\-CCR2b/\-CXCR4

Guillon98

RH-2-7 C12

BC

YES

INTERMED

CCR5

CCR3/\-CXCR4/\-CCR1

Guillon98

RH-2-7 D7

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

CXCR4/\-CCR2b

Guillon98

RH-2-7 G12

BC

YES

INTERMED

CCR5/\-CCR3/\-CCR1

CXCR4/\-CCR2b

Guillon98

RH-2-2

S

YES

LATE

CCR3/\-CCR1/\-CXCR4/\-CCR5

CCR2b

Guillon98

RH-2-6

S

YES

LATE

CXCR4

Guillon98

MLC

yes

symp

CCR5

CCR1, CCR3

Reeves99

TER

YES

AIDS

CCR5, CCR1, CCR3

+

Reeves99

ALI

YES

AIDS-rel-compx

CCR5

CCR1, CXCR4

+

Reeves99

ETP

YES

symp

CCR5, CXCR4, CCR1, CCR2b, CCR3

+

Reeves99

JAU

YES

AIDS

CCR5, CXCR4, CCR1, CCR2b, CCR3

+

Reeves99

MIL

YES

AIDS

CXCR4

+

Reeves99

SAB

YES

AIDS

CXCR4

CCR3

+

Reeves99

1010

YES

AIDS

CCR1, CCR2b, CCR3, CCR5, CXCR4

gpr15, STRL33

Morner99

1654

YES

AIDS

CCR5

CCR1, CCR3, gpr15, STRL33

Morner99

1682

YES

asymp

CCR1, CCR3, CCR5

CCR2b, gpr15, STRL33

Morner99

1808

YES

asthenia

CCR1, CCR3, CCR5

gpr15, STRL33

Morner99

1812

YES

AIDS

CCR5

gpr15

Morner99

1816

YES

AIDS

CCR5

CCR1, CCR2b, gpr15, STRL33

Morner99

2297

YES

asthenia

CCR5, gpr15

CCR1, STRL33

Morner99

2298

YES

asymp

CCR5

CCR2b, gpr15, STRL33

Morner99

2300

YES

AIDS

CCR1, CCR3, CCR5

gpr15, STRL33

Morner99

6669

YES

AIDS

CCR3, CXCR4

gpr15, STRL33

Morner99

1653

YES

AIDS

CCR5

gpr15

Morner99

last modified: Fri Aug 10 14:02 2007


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