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Notes to HIV-1 Coreceptor Use Table

a Accession numbers refer to sequences from the described isolate that contain the longest available sequence including Env (full length genome when available, down to a minimum of the V3 region), but may not pertain directly to the sample used to determine the isolate's phenotype. Accession numbers have been deemed "NA" if there are no related locus names in the HIV Database, or if there is insufficient information to conclude that a similarly named locus in the database is referring to the same isolate.

b The tropism for each virus strain is indicated. SI = syncytium inducing; NSI = non syncytium inducing; SI/TCLA = syncytium inducing T-cell line adapted; NA = not available.

c As described in the text, we have proposed that viruses which use CCR5 be termed R5 viruses, viruses that use CXCR4 be termed X4 viruses, and viruses that use both be termed R5X4 viruses. For a virus to be termed an R5X4 virus, CXCR4 must be used at > 10% of the efficiency of CCR5 for viruses that use CCR5 as their primary receptor, or CCR5 must be used at > 10% of the efficiency of CXCR4 for viruses that use CXCR4 as their primary receptor.

d All virus strains in the Table have been tested for the ability to use CCR5 and CXCR4. The receptors used by each strain are indicated. For both receptors to be listed, the least efficiently used receptor must support virus entry by >10% of the levels supported by the most efficiently used receptor. For viruses that use both receptors, CXCR4 is listed first; this does not mean that CXCR4 is used more efficiently than CCR5.

e Receptors other than CCR5 or CXCR4 that are used by the indicated strains are listed. Since most viruses have not yet been tested for the ability to use receptors other than CCR5 and CXCR4, the absence of other receptors used in the Table should not be taken to mean that a virus uses only CCR5 or CXCR4. For example, if CCR3 is not listed as being used by a given virus strain, it may be because it has not yet been tested. Receptors that have been shown by experiments not to be used by a given virus strain are not indicated. Occasionally there are discrepancies in the literature concerning the use of one or more receptors. In these cases, we opted for 'majority rules'. If two papers report a positive result and one a negative result, the receptor is shown as being used.

f The virus isolate used CCR3 whereas the cloned env from this isolate did not Bjorndal97. *Indicates that coreceptor use was determined only by fusion assays rather than by virus infection.

g 92HT593.1 (cloned env gene) and 92HA593 (whole virus) come from the same isolate and gave slightly different results in references Dittmar97 and Zhang96.

h Tybe is a cerebrospinal fluid isolate from an individual with AIDS from the US northeast and likely a clade B isolate.

i Under the new nomenclature proposal, subtype E will be referred to as CRF01(AE)

Strain

Proposed Accessiona

Primary Clade

Other Tropismb

Designationc

Main Receptord

Alternate Receptorse

References

DJ258

L22939

A

NSI

R5

CCR5

Trkola98

92RW026

U13458

A

NSI

R5

CCR5

Trkola98

93KE101

NA

A

NSI

R5

CCR5

Zhang96

93IN103

NA

A

NSI

R5

CCR5

Zhang96

92UG037-8

U51190

A

NSI

R5

CCR5

CCR8*

Bjorndal97,Rucker97

92RW020-5

U08794

A

NSI

R5

CCR5

Rucker97

92UG031

L34667

A

NSI

R5

CCR5

Dittmar97

92RW20

U08794

A

NSI

R5

CCR5

Dittmar97

92UG029

U13469

A

SI

X4

CXCR4

Trkola98

92RW009

U88823

A

SI

R5X4

CXCR4, CCR5

Zhang96

JR-FL

U63632

B

NSI

R5

CCR5

CCR3

Deng97,Farzan97,Rucker97

JR-CSF

M38429

B

NSI

R5

CCR5

Simmons96,Trkola98,Zhang96

SF162

M65024

B

NSI

R5

CCR5

STRL33*

Liao97,Rucker97

YU2

M93258

B

NSI

R5

CCR5

CCR3, GPR15

Choe96,Farzan97

ADA

AF004394

B

NSI

R5

CCR5

CCR3, GPR15, STRL33*, CCR8

Choe96,Farzan97,Rucker97

Ba-L

M68893

B

NSI

R5

CCR5

CCR3, STRL33*

Deng97,Dragic96,Liao97,Rucker97

92US657

U04908

B

NSI

R5

CCR5

Trkola98

92US715.6

U08451

B

NSI

R5

CCR5

Bjorndal97

92Br20-4

U08797

B

NSI

R5

CCR5

GPR15

Choe96,Rucker97,Pohlmann99

91US005.11

U27434

B

NSI

R5

CCR5

GPR15

Bjorndal97,Rucker97,Pohlmann99

SL-2

NA

B

NSI

R5

CCR5

Simmons96

92TH014.12

U08801

B

NSI

R5

CCR5

Bjorndal97

M23

NA

B

NSI

R5

CCR5

Dittmar97

E80

NA

B

NSI

R5

CCR5

Dittmar97

BR92

NA

B

NSI

R5

CCR5

Dittmar97

BR49

NA

B

NSI

R5

CCR5

Dittmar97

BR53

NA

B

NSI

R5

CCR5

Dittmar97

BR90

NA

B

NSI

R5

CCR5

Dittmar97

92HA593g

U08444

B

SI

R5X4

CXCR4, CCR5

Zhang96

92HT593.1g

U08444

B

NSI

R5X4

CXCR4, CCR5

GPR15, STRL33

Bjorndal97,Pohlmann99

2028

NA

B

SI

R5X4

CXCR4, CCR5

CCR3

Dittmar97,Simmons96

2076

NA

B

SI

R5X4

CXCR4, CCR5

Dittmar97,Simmons96,Trkola98

89.6

U39362

B

SI

R5X4

CXCR4, CCR5

CCR3, CCR2b, CCR8, V28

Farzan97,Rucker97

DH123

AF069140

B

SI

R5X4

CXCR4, CCR5

Trkola98

Isolate C 7/86

NA

B

SI

R5X4

CXCR4, CCR5

Trkola98

92HA594

U08445

B

SI

R5X4

CXCR4, CCR5

Zhang96

92HA596

U08446

B

SI

R5X4

CXCR4, CCR5

Zhang96

M13

NA

B

SI

R5X4

CXCR4, CCR5

Simmons96

2006

NA

B

SI

R5X4

CXCR4, CCR5

Simmons96

2044

NA

B

SI

R5X4

CXCR4, CCR5

Simmons96

2036

NA

B

SI

R5X4

CXCR4, CCR5

Simmons96

2005

NA

B

SI

R5X4

CXCR4, CCR5

Simmons96

92HT599.24

U08447

B

SI

X4

CXCR4

Bjorndal97

BK132

L03697

B

SI

X4

CXCR4

CCR3*, CCR8*

Rucker97,Broder97

BR65

NA

B

SI

X4

CXCR4

Dittmar97

HC4

NA

B

SI

X4

CXCR4

Trkola98

SF2

K02007

B

SI/TCLA

R5X4

CXCR4, CCR5

Trkola98

RF

M17451

B

SI/TCLA

R5X4

CXCR4, CCR5

Alkhatib96,Deng97,Rucker97

NL4-3

M19921

B

SI/TCLA

R4,X4

CXCR4

Zhang96,Trkola98,Zhang98

LAI(IIIB)

X01762

B

SI/TCLA

X4

CXCR4

Trkola98

HXBc2

K03455

B

SI/TCLA

X4

CXCR4

Choe96

GUN-1

D34590

B

SI/TCLA

R5X4

CXCR4, CCR5

Simmons96

BH8

K02011

B

SI/TCLA

X4

CXCR4

CCR3*, STRL33*

Rucker97

P1 22-211-V4

AF112563

B

NSI

R5

CCR5

Zhang98

P2 22-204-V2

NA

B

NSI

R5

CCR5

Zhang98

P3 19-245-V6

NA

B

NSI

R5

CCR5

Zhang98

P4 03-212-V8

NA

B

NSI

R5

CCR5

Zhang98

P5 11-213-V4

NA

B

NSI

R5

CCR5

Zhang98

P6 02-217-V3

NA

B

NSI

R5

CCR5

BONZO

Zhang98

P7 22-216-V5

NA

B

NSI

R5

CCR5

Zhang98

P8 02-236-V6

NA

B

NSI

R5

CCR5

Zhang98

P9 22-236-V6

NA

B

NSI

R5

CCR5

Zhang98

P10 03-237-V6

NA

B

NSI

R5

CCR5

Zhang98

P11 22-202-V3

AF112548

B

NSI

R5

CCR5

Zhang98

P13 19-242-V3

AF112542

B

NSI

R5

CCR5

Zhang98

P14 22-207-V6

NA

B

NSI

R5

CCR5

Zhang98

P15 22-237-V4

AF112565

B

NSI

R5

CCR5

Zhang98

301657

NA

B

NSI

R5

CCR5

Zhang98

301714

NA

B

NSI

R5

CCR5

Zhang98

301073

NA

B

NSI

R5

CCR5

Zhang98

301056

NA

B

NSI

R5

CCR5

Zhang98

301660

NA

B

NSI

R5

CCR5

Zhang98

301727

NA

B

NSI

R5

CCR5

Zhang98

MWB

NA

B

NSI

R5

CCR5

Zhang98

301593

NA

B

SI

R5X4

CXCR4, CCR5

V28

Zhang98

AD73

NA

B

SI

R5X4

CXCR4, CCR5

V28

Zhang98

DH123

NA

B

SI

R5X4

CXCR4, CCR5

CCR8

Zhang98

P6 02-217-V3-m1

NA

B

NSI

R5

CCR5

BONZO

Zhang98

P6 02-217-V4 m2

NA

B

NSI

R5

CCR5

BONZO

Zhang98

P6-02-217-V6-m6

NA

B

NSI

R5

CCR5

BONZO

Zhang98

P6 02-217-V8-m12

NA

B

NSI

R5

CCR5

BONZO

Zhang98

P6 02-217-V9-m18

NA

B

NSI

R5

CCR5

Zhang98

M6-V2-m4b

NA

B

SI

R5X4

CXCR4, CCR5

BONZO, V28, APJ

Zhang98

M6-V3-m1b

NA

B

SI

R5X4

CXCR4, CCR5

BONZO, V28, APJ

Zhang98

M6-V6-m6a

NA

B

SI

R5X4

CXCR4, CCR5

BONZO, V28, APJ

Zhang98

EL1

NA

B

SI

X4

CXCR4

APJ, CCR3

Choe98

2005

NA

B

SI

X4

CXCR4

Simmons98

2044

NA

B

SI

X4

CXCR4

Simmons98

2028

NA

B

SI

R5X4

CXCR4, CCR5

Simmons98

2076

NA

B

SI

R5X4

CXCR4, CCR5

CCR3, CCR8, STRL33

Simmons98

SL-2

NA

B

NSI

R5

CCR5

GPR15

Simmons98

92US076

NA

B

SI

R5X4

CCR5, CXCR4

CCR3

Xiao98

Tybe

(B)h

SI

X4

CXCR4

Yi99

92ZW101

NA

C

NSI

R5

CCR5

Zhang96

92BR025.9

U52953

C

NSI

R5

CCR5

GPR15

Bjorndal97,Dittmar97,Pohlmann99

BR28

U16217

C

NSI

R5

CCR5

Dittmar97

93MW965.26

U08455

C

NSI

R5

CCR5

Bjorndal97

BR70

NA

C

NSI

R5

CCR5

Dittmar97

JW1

NA

C

NSI

R5

CCR5

Dittmar97

JW4

NA

C

NSI

R5

CCR5

Dittmar97

92ZW102

NA

C

NSI

R5

CCR5

Zhang96

DJ259

L22940

C

NSI

R5

CCR5

Trkola98

94ZW103

NA

C

NSI

R5

CCR5

Trkola98

94ZW109

NA

C

NSI

R5

CCR5

Trkola98

92ZW106

NA

C

SI

X4

CXCR4

Zhang96

ZAM20

L22956

C

SI

X4

CXCR4

Trkola98

94ZW106

NA

C

SI

X4

CXCR4

Trkola98

E3098

NA

C

NSI

R5

CCR5

Bjorndal99

E3099

U92051

C

NSI

R5

CCR5

Bjorndal99

E3100

NA

C

NSI

R5

CCR5

Bjorndal99

E3101

NA

C

NSI

R5

CCR5

Bjorndal99

E3347

NA

C

NSI

R5

CCR5

Bjorndal99

E3348

NA

C

NSI

R5

CCR5

Bjorndal99

E3349

NA

C

NSI

R5

CCR5

Bjorndal99

E3350

U45485

C

NSI

R5

CCR5

Bjorndal99

E3526

NA

C

NSI

R5

CCR5

Bjorndal99

94KE102

NA

D

NSI

R5

CCR5

Trkola98,Zhang96

94KE103

NA

D

NSI

R5

CCR5

Trkola98,Zhang96

92UG046

U08737

D

SI

X4

CXCR4

Trkola98

UG270

NA

D

SI

X4

CXCR4

Trkola98

92UG024.2

U08726

D

SI

X4

CXCR4

CCR8*, V28*, CCR3, GPR15, STRL33f

Bjorndal97,Rucker97,Trkola98,Pohlmann99,Broder97

92UG021.16

U27399

D

SI

X4

CXCR4

Bjorndal97

JW5

NA

D

SI

X4

CXCR4

Dittmar97

NDK

M27323

D

SI

X4

CXCR4

GPR15

Deng97,Pleskoff97b

93ZR001.3

U27419

D

NA

X4

CXCR4

V28*

Rucker97

91ZR001.3

NA

D

SI

R5X4

CXCR4, CCR5

Bazan98

SE7076

NA

D

SI

X4

CXCR4

Vallejo98

SE8384

NA

D

SI

X4

CXCR4

Vallejo98

SE8646

NA

D

SI

R5X4

CCR5, CXCR4

Vallejo98

92UG001

U13520

D

SI

R5X4

CCR5, CXCR4

CCR1, CCR2b, CCR3

Xiao98

CM235

L03698

Ei

SI

R5

CCR5

Trkola98,Broder97

CM243

L03703

E

NSI

R5

CCR5

GPR15, STRL33

Rucker97,Broder97

92TH001

U08742

E

NSI

R5

CCR5

Trkola98

M53

NA

E

NSI

R5

CCR5

Dittmar97

92TH022

U09131

E

NSI

R5

CCR5

Dittmar97

92TH023

U08760

E

NSI

R5

CCR5

Dittmar97

C2

NA

E

NSI

R5

CCR5

Dittmar97

93TH305

NA

E

NSI

R5

CCR5

Zhang96

93TH307

NA

E

NSI

R5

CCR5

Zhang96

93TH966.8

U08456

E

NSI

R5

CCR5

Bjorndal97

93TH976.17

U08458

E

NA

R5

CCR5

Bjorndal97

93TH304

NA

E

SI

R5X4

CXCR4, CCR5

Zhang96

SL6

NA

E

SI

X4

CXCR4

Dittmar97

SL7

NA

E

SI

X4

CXCR4

Dittmar97

SL8

NA

E

SI

X4

CXCR4

Dittmar97

94TH304

NA

E

SI

X4

CXCR4

Trkola98

CMU02

U48207

E

SI

X4

CXCR4

Xiao98

CMU08

U48268

E

SI

X4

CXCR4

AIDS Ref Reag Prog

BR58

NA

F

SI

R5X4

CXCR4, CCR5

CCR3

Dittmar97

BZ162

L22084

F

NSI

R5

CCR5

Trkola98

R1

NA

F

NSI

R5

CCR5

Trkola98

93BR029.2

U27413

F

NA

R5

CCR5

Rucker97

RU23

U69657

F

NSI

R5

CCR5

Vallejo98

RU29

U69663

F

NSI

R5

CCR5

Vallejo98

RU30

U69664

F

NSI

R5

CCR5

Vallejo98

93BR020

AF005494

F

SI

R5X4

CCR5, CXCR4, CCR3

Xiao98

92UG975.10

U27426

G

NSI

R5

CCR5

Bjorndal97

CA9

X96522

O

NSI

R5

CCR5

Zhang96

MVP5180

L20571

O

SI

R5X4

CXCR4, CCR5

Zhang96

ES1158.1

AF009608

O

NSI

R5

CCR5

Vallejo98

ES1159.1

AF009611

O

NSI

R5

CCR5

Vallejo98

MD.1

NA

O

NSI

R5

CCR5

Vallejo98

MVP-5180

L20571

O

SI

R5X4

CCR1, CCR2b, CCR3, CCR4, CCR5, CXCR4

Vallejo98,Xiao98

8913-95

NA

O

R5

CCR5

Dittmar99

1639-96

NA

O

R5

CCR5

Dittmar99

13127-96

NA

O

R5

CCR5

Dittmar99

13470-96

NA

O

R5

CCR5

Dittmar99

2171-94

NA

O

X4

CXCR4

STRL33, CCR8

Dittmar99

2901-94

NA

O

R5

CCR5

Dittmar99

4354-94

NA

O

R5

CCR5

Dittmar99

6778-94

NA

O

R5

CCR5

Dittmar99

8161-94

NA

O

X4

CXCR4

Dittmar99

4974-95

NA

O

R5

CCR5

Dittmar99

9435-96

NA

O

R5

CCR5

Dittmar99

2274-97

NA

O

R5

CCR5

Dittmar99

last modified: Wed Sep 16 14:10 2009


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