Found 1 matching record:
HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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Epitope |
KRWIILGLNK
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B*27:05) |
Showing 1 of 5 variants.
Variant ID. | 730 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWIImGLNK |
Mutations | L/M |
Epitope Location | L6M |
HXB2 Location | L268M |
Mutation Type | CM: compensatory mutation |
Method | Tetramer binding |
Note | Variant was present in 1/25 of the viral sequences 52 weeks after infection in one of the patients. Mutation occurs relatively early in the infection. L/M may be a compensatory mutation. |
Kelleher2001 A. D. Kelleher, C. Long, E. C. Holmes, R. L. Allen, J. Wilson, C. Conlon, C. Workman, S. Shaunak, K. Olson, P. Goulder, C. Brander, G. Ogg, J. S. Sullivan, W. Dyer, I. Jones, A. J. McMichael, S. Rowland-Jones, and R. E. Phillips. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med., 193(3):375-86, 5 Feb 2001. URL: http://www.jem.org/cgi/content/full/193/3/375. PubMed ID: 11157057. Show all entries for this paper.
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