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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 1352

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   compensatory mutation
Species (MHC/HLA human(B*27:05)

Variant Details

Showing 1 of 5 variants.


Variant ID.  730
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type CM: compensatory mutation
Method Tetramer binding
Note Variant was present in 1/25 of the viral sequences 52 weeks after infection in one of the patients. Mutation occurs relatively early in the infection. L/M may be a compensatory mutation.

References

Kelleher2001 A. D. Kelleher, C. Long, E. C. Holmes, R. L. Allen, J. Wilson, C. Conlon, C. Workman, S. Shaunak, K. Olson, P. Goulder, C. Brander, G. Ogg, J. S. Sullivan, W. Dyer, I. Jones, A. J. McMichael, S. Rowland-Jones, and R. E. Phillips. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med., 193(3):375-86, 5 Feb 2001. URL: http://www.jem.org/cgi/content/full/193/3/375. PubMed ID: 11157057. Show all entries for this paper.


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