Found 1 matching record:
HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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Epitope |
KRWIILGLNK
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Epitope Alignment | ||||
Variants |
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Epitope Name | KK10 | |||||
Species (MHC/HLA) | human(B27) |
Showing 1 of 5 variants.
Variant ID. | 394 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KtWIImGLNK |
Mutations | R/T L/M |
Epitope Location | R2T L6M |
HXB2 Location | R264T L268M |
Mutation Type | CM: compensatory mutation DHB: diminished HLA binding or increased off-rate |
Method | CD8 T-cell Elispot - IFNy |
Note | The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. The variant had presumed compensatory L/M mutation |
Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.
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