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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 1818

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KtWIImGLNK   compensatory mutation; diminished HLA binding or increased off-rate
Epitope Name KK10
Species (MHC/HLA human(B27)

Variant Details

Showing 1 of 5 variants.


Variant ID.  394
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIImGLNK
Mutations R/T L/M
Epitope Location R2T L6M
HXB2 Location R264T L268M
Mutation Type CM: compensatory mutation
DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. The variant had presumed compensatory L/M mutation

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


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