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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 1818

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIImGLNK   diminished HLA binding or increased off-rate
Epitope Name KK10
Species (MHC/HLA human(B27)

Variant Details

Showing 1 of 5 variants.


Variant ID.  392
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DHB: diminished HLA binding or increased off-rate
Method HLA binding
Note Variant bound to B27 poorly compared to the wt.

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


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