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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 58688

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TSTLQEQxAW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:02, B*57:03, B*58:01)

Variant Details

Showing 1 of 2 variants.


Variant ID.  3103
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQxAW
Mutations I/X
Epitope Location I8X
HXB2 Location I247X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation TSTLQEQxAW was seen in ˜25% of HLA-B*5703-positive subjects, and in very few HLA-B*5801 or -B*5702 carrying subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


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