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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 57353

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQItW   non-susceptible form; replicative capacity reduced; susceptible form
Epitope Name TW10
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing 1 of 27 variants.


Variant ID.  3017
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQItW
Mutations T/N G/T
Epitope Location T3N G9T
HXB2 Location T242N G248T
Mutation Type NSF: non-susceptible form
RCR: replicative capacity reduced
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay, Sequence
Note Variant TSnLQEQItW (author designation T242N/G248N) displayed very slightly reduced replication capacity at 92% of wild type virus. The subject carrying this autologous virus was able to recognize the variant peptide even more strongly than wild type TW10. All subjects tested who recognized the T242N variant of TW10, whether they were controllers or not, were also able to recognize variant peptides of the T242N/G248X pattern (including this peptide, TSnLQEQItW). The variant, however, was not recognized by any subject where it was a non-autologous sequence.

References

Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.


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