Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
Variants |
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Epitope Name | TW10 | |||||
Species (MHC/HLA) | human(B*57, B*58:01) |
Showing 1 of 27 variants.
Variant ID. | 3017 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQItW |
Mutations | T/N G/T |
Epitope Location | T3N G9T |
HXB2 Location | T242N G248T |
Mutation Type | NSF: non-susceptible form RCR: replicative capacity reduced SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay, Sequence |
Note | Variant TSnLQEQItW (author designation T242N/G248N) displayed very slightly reduced replication capacity at 92% of wild type virus. The subject carrying this autologous virus was able to recognize the variant peptide even more strongly than wild type TW10. All subjects tested who recognized the T242N variant of TW10, whether they were controllers or not, were also able to recognize variant peptides of the T242N/G248X pattern (including this peptide, TSnLQEQItW). The variant, however, was not recognized by any subject where it was a non-autologous sequence. |
Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.
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