Found 1 matching record:
HXB2 Location | Gag(77-86) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATLY
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Epitope Alignment | ||||
Variants |
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Epitope Name | SY10 | |||||
Species (MHC/HLA) | human(A*02) |
Showing 1 of 7 variants.
Variant ID. | 2993 |
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Epitope Seq. | SLYNTVATLY |
Variant Seq. | SLfNTVAvLY |
Mutations | Y/F T/V |
Epitope Location | Y3F T8V |
HXB2 Location | Y79F T84V |
Mutation Type | DHB: diminished HLA binding or increased off-rate E: escape documented in this paper SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, HLA binding |
Note | Variant SLfNTVAvLY could not bind HLA-A*02 in vitro; but did elicit ex-vivo EliSpot responses in at least 1 of 3 chronically-infected, untreated patients. The authors refer to all Y79F mutation-containing peptides as escapes. |
Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.
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