Found 1 matching record:
HXB2 Location | Gag(76-86) | Gag Epitope Map
View variants at this location |
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Epitope |
RSLYNTVATLY
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Epitope Alignment | ||||
Variants |
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Epitope Name | RY11 | |||||
Species (MHC/HLA) | human(A*02:01, A*30:02) |
Showing 1 of 15 variants.
Variant ID. | 2986 |
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Epitope Seq. | RSLYNTVATLY |
Variant Seq. | kSLfNTVAvLY |
Mutations | R/K Y/F T/V |
Epitope Location | R1K Y4F T9V |
HXB2 Location | R76K Y79F T84V |
Mutation Type | DHB: diminished HLA binding or increased off-rate DR: diminished response E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, HLA binding |
Note | Variant kSLfNTVAvLY lost binding to HLA-A*02 in vitro; and it showed a significant decrease in EliSpot response in 2 chronically-infected, untreated patients; and abrogation of CTL response in the third. The authors designate Y79F or T84V mutation-containing peptides as escapes. |
Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.
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