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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 58384

HXB2 Location  Gag(58-72)   Gag Epitope Map
View variants at this location
Epitope KQIMKQLQPALQTGT   Epitope Alignment
Variants
cqQImeQLQsALkTse   subtype-specific non-susceptible form
Epitope Name Peptide 15
Species (MHC/HLA human

Variant Details

Showing 1 of 4 variants.


Variant ID.  2910
Epitope Seq.  xKQIMKQLQPALQTGT
Variant Seq.  cqQImeQLQsALkTse
Mutations x/C P/S Q/K G/S T/E K/Q K/E
Epitope Location x1C P10S Q13K G15S T16E K2Q K6E
HXB2 Location x58C P67S Q70K G72S T73E K59Q K63E
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 15, cqQImeQLQsALkTse, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


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