Found 1 matching record:
HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A*02:01) |
Showing 1 of 4 variants.
Variant ID. | 1881 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SvYNTVATL |
Mutations | L/V |
Epitope Location | L2V |
HXB2 Location | L78V |
Mutation Type | E: escape documented in this paper P: processing SF: susceptible form |
Method | Chromium-release assay |
Note | This variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed. |
Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.
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