Found 1 matching record:
HXB2 Location | Gag(28-36) | Gag Epitope Map
View variants at this location |
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Epitope |
KYKLKHIVW
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A24) |
Showing 1 of 3 variants.
Variant ID. | 1877 |
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Epitope Seq. | KYKLKHIVW |
Variant Seq. | KYrLKHlVW |
Mutations | K/R I/L |
Epitope Location | K3R I7L |
HXB2 Location | K30R I34L |
Mutation Type | E: escape documented in this paper P: processing SF: susceptible form |
Method | Chromium-release assay |
Note | This 3R variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed. Only 1/8 screened A24-positive individuals had CTL activity against this mutant. |
Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.
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