Found 1 matching record:
HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||
Variants |
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Epitope Name | SL9 | |||||
Species (MHC/HLA) | human(A2) |
Showing 1 of 6 variants.
Variant ID. | 1860 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNlVAvL |
Mutations | T/L T/V |
Epitope Location | T5L T8V |
HXB2 Location | T81L T84V |
Mutation Type | E: escape documented in this paper NSF: non-susceptible form TCR: TCR related mutation |
Method | Chromium-release assay, Relative replication capacity assay, Sequence |
Note | CTL Clones 18030D23 and 161JxA14 from different subjects do not recognize this variant. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance. |
Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.
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