Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
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Epitope |
TSTLQEQIGW
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Variants |
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Epitope Name | TW10 | ||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*57:01) |
Showing all: 8 variant(s).
Variant ID. | 3348 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLrEQIGW |
Mutations | Q/R |
Epitope Location | Q5R |
HXB2 Location | Q244R |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSTLrEQIGW was seen in 1/3 HRP (patient P1) subjects. |
Variant ID. | 3349 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIeW |
Mutations | Q/R G/E |
Epitope Location | Q5R G9E |
HXB2 Location | Q244R G248E |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSTLQEQIeW was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient 5) subjects. |
Variant ID. | 3350 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSsLQEQIGW |
Mutations | T/S |
Epitope Location | T3S |
HXB2 Location | T242S |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSTLrEQIeW was seen in 1/3 HRP (patient P2) subjects. |
Variant ID. | 3351 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIGW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | E: escape documented in this paper OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSnLQEQIGW, TW10-3N was seen in all 6 HRP and LRP subjects. |
Variant ID. | 3352 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIrW |
Mutations | T/N G/R |
Epitope Location | T3N G9R |
HXB2 Location | T242N G248R |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSnLQEQIrW was seen in all 1/3 HRP (patient P2) subjects. |
Variant ID. | 3353 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQItW |
Mutations | T/N G/T |
Epitope Location | T3N G9T |
HXB2 Location | T242N G248T |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSnLQEQItW was seen in all 1/3 HRP (patient P2) subjects. |
Variant ID. | 3354 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIaW |
Mutations | T/N G/A |
Epitope Location | T3N G9A |
HXB2 Location | T242N G248A |
Mutation Type | E: escape documented in this paper OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSnLQEQIaW, TW10-3N-9A, was seen in 1/3 HRP (patient P3) and 1/3 LRP (patient 5) subjects. It was the analogous epitope of the major viral population at the last time point in patient P1, the earliest time point in patients P2 and P3, and the only variant in LRP patients P4 and P6. |
Variant ID. | 3355 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIaW |
Mutations | G/A |
Epitope Location | G9A |
HXB2 Location | G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | HLA binding, Intracellular cytokine staining, Sequence |
Note | Variant TSTLQEQIaW was seen in 1/3 LRP (patient 5) subjects. |
Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.
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