logo image

HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59210

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLrEQIGW   observed variant
TSTLQEQIeW   observed variant
TSsLQEQIGW   observed variant
TSnLQEQIGW   escape documented in this paper; observed variant
TSnLQEQIrW   observed variant
TSnLQEQItW   observed variant
TSnLQEQIaW   escape documented in this paper; observed variant
TSTLQEQIaW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 8 variant(s).


Variant ID.  3348
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLrEQIGW
Mutations Q/R
Epitope Location Q5R
HXB2 Location Q244R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLrEQIGW was seen in 1/3 HRP (patient P1) subjects.


Variant ID.  3349
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIeW
Mutations Q/R G/E
Epitope Location Q5R G9E
HXB2 Location Q244R G248E
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLQEQIeW was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient 5) subjects.


Variant ID.  3350
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSsLQEQIGW
Mutations T/S
Epitope Location T3S
HXB2 Location T242S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLrEQIeW was seen in 1/3 HRP (patient P2) subjects.


Variant ID.  3351
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIGW, TW10-3N was seen in all 6 HRP and LRP subjects.


Variant ID.  3352
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIrW
Mutations T/N G/R
Epitope Location T3N G9R
HXB2 Location T242N G248R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIrW was seen in all 1/3 HRP (patient P2) subjects.


Variant ID.  3353
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQItW
Mutations T/N G/T
Epitope Location T3N G9T
HXB2 Location T242N G248T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQItW was seen in all 1/3 HRP (patient P2) subjects.


Variant ID.  3354
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIaW
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIaW, TW10-3N-9A, was seen in 1/3 HRP (patient P3) and 1/3 LRP (patient 5) subjects. It was the analogous epitope of the major viral population at the last time point in patient P1, the earliest time point in patients P2 and P3, and the only variant in LRP patients P4 and P6.


Variant ID.  3355
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLQEQIaW was seen in 1/3 LRP (patient 5) subjects.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.

Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Copyright Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services LANL logo National Institutes of Health logo