Found 1 matching record:
HXB2 Location | Gag(151-159) | Gag Epitope Map
View variants at this location |
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Epitope |
TLNAWVKVV
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Epitope Alignment | ||||
Variants |
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Epitope Name | TV9 | |||||
Species (MHC/HLA) | (A*02:01) |
Showing all: 1 variant(s).
Variant ID. | 2569 |
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Epitope Seq. | TLNAWVKVV |
Variant Seq. | kINAWiKVV |
Mutations | T/K L/I V/I |
Epitope Location | T1K L2I V6I |
HXB2 Location | T151K L152I V156I |
Mutation Type | SF: susceptible form |
Method | Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding |
Note | This is a mimic peptide shown to consistently activate cross-reactive and equally functional CTLs as measured by cytotoxicity, cytokine production and suppression of HIV replication in vitro. |
Schaubert2010 Keri L. Schaubert, David A. Price, Janelle R. Salkowitz, Andrew K. Sewell, John Sidney, Tedi E. Asher, Sylvie E. Blondelle, Sharon Adams, Francesco M. Marincola, Aviva Joseph, Alessandro Sette, Daniel C. Douek, Velpandi Ayyavoo, Walter Storkus, Ming-Ying Leung, Hwee L. Ng, Otto O. Yang, Harris Goldstein, Darcy B. Wilson, and June Kan-Mitchell. Generation of Robust CD8+ T-Cell Responses Against Subdominant Epitopes in Conserved Regions of HIV-1 by Repertoire Mining with Mimotopes. Eur. J. Immunol., 40(7):1950-1962, Jul 2010. PubMed ID: 20432235. Show all entries for this paper.
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