Found 1 matching record:
HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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Epitope |
TPQDLNTML
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Epitope Alignment | ||||||||||
Variants |
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Species (MHC/HLA) | human(B*81) |
Showing all: 3 variant(s).
Variant ID. | 1523 |
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Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDmNTML |
Mutations | L/M |
Epitope Location | L5M |
HXB2 Location | L184M |
Mutation Type | CE: calculated escape |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation. |
Variant ID. | 1524 |
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Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDsNTML |
Mutations | L/S |
Epitope Location | L5S |
HXB2 Location | L184S |
Mutation Type | CE: calculated escape |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation. |
Variant ID. | 1525 |
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Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDyNTML |
Mutations | L/Y |
Epitope Location | L5Y |
HXB2 Location | L184Y |
Mutation Type | CE: calculated escape |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Variants TPQDmNTML, TPQDyNTML, TPQDsNTML were resistant to CTL response, but associated with lower viral loads, suggesting a fitness cost to the mutation. |
Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.
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