Found 1 matching record:
HXB2 Location | Gag(77-85) | Gag Epitope Map
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Epitope |
SLYNTVATL
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Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | SL9 | ||||||||||||||
Species (MHC/HLA) | human(A*02) |
Showing all: 4 variant(s).
Variant ID. | 633 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiATL |
Mutations | V/I |
Epitope Location | V6I |
HXB2 Location | V82I |
Mutation Type | SF: susceptible form |
Method | CD8 T-cell Elispot - IFNy |
Note | A major variant detected by week 39 in one of the patients that induced a CTL response. |
Variant ID. | 634 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTiATL |
Mutations | Y/F V/I |
Epitope Location | Y3F V6I |
HXB2 Location | Y79F V82I |
Mutation Type | DR: diminished response E: escape documented in this paper |
Method | CD8 T-cell Elispot - IFNy |
Note | Variant detected by week 63. Lower magnitude responses than wt and V/I mutant. Positive selection. Seen with upstream changes E62G/V/A, where the 62A mutation persisted and is suggested to reduce fitness cost of the Y/F escape mutation. |
Variant ID. | 635 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNaiATL |
Mutations | T/A V/I |
Epitope Location | T5A V6I |
HXB2 Location | T81A V82I |
Mutation Type | IE: inferred escape |
Method | CD8 T-cell Elispot - IFNy |
Note | Author tabulates this variant detected in 1/14 clones at week 39 in patients. OP428 as viral escape. No CTL response detected. |
Variant ID. | 636 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLcNTiATL |
Mutations | Y/C V/I |
Epitope Location | Y3C V6I |
HXB2 Location | Y79C V82I |
Mutation Type | IE: inferred escape |
Method | CD8 T-cell Elispot - IFNy |
Note | Author tabulates this variant as a viral escape, detected in 1/12 clones at week 63 in patient OP428. No CTL response detected. |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
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