Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
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Epitope |
TSTLQEQIGW
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Epitope Alignment | |||||||||||||||||||||||||||||||||||||
Variants |
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Epitope Name | TW10 | ||||||||||||||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*57, B*58:01) |
Showing all: 12 variant(s).
Variant ID. | 1070 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLaEQIaW |
Mutations | T/N Q/A G/A |
Epitope Location | T3N Q5A G9A |
HXB2 Location | T242N Q244A G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This triple variant was found in 1/80 HLA-B*57/58 subjects infected by Clade B HIV-1, and in 0/239 HLA-B*57/5801 negative subjects. |
Variant ID. | 1071 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIaW |
Mutations | T/N G/A |
Epitope Location | T3N G9A |
HXB2 Location | T242N G248A |
Mutation Type | E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence |
Note | This previously suggested escape, a double variant was found in 30/80 HLA-B*57/58 subjects infected by Clade B HIV-1, but only in 1/239 HLA-B*57/5801 negative subjects. It abrogates recognition completely at low peptide concentrations. |
Variant ID. | 1072 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQItW |
Mutations | T/N G/T |
Epitope Location | T3N G9T |
HXB2 Location | T242N G248T |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This double variant was found in 4/80 HLA-B*57/58 subjects, but in none of 107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. |
Variant ID. | 1073 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIqW |
Mutations | T/N G/Q |
Epitope Location | T3N G9Q |
HXB2 Location | T242N G248Q |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This double variant was found in 3/80 HLA-B*57/58 subjects infected with Clade B HIV-1, but in no HLA-B*57/5801 negative subjects. |
Variant ID. | 1074 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLsEQIaW |
Mutations | T/N Q/S G/A |
Epitope Location | T3N Q5S G9A |
HXB2 Location | T242N Q244S G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects. |
Variant ID. | 1075 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQvaW |
Mutations | T/N I/V G/A |
Epitope Location | T3N I8V G9A |
HXB2 Location | T242N I247V G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects. |
Variant ID. | 1076 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TtnLQEQIaW |
Mutations | S/T T/N G/A |
Epitope Location | S2T T3N G9A |
HXB2 Location | S241T T242N G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects. |
Variant ID. | 1077 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSThQEQIaW |
Mutations | L/H G/A |
Epitope Location | L4H G9A |
HXB2 Location | L243H G248A |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This double variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects. |
Variant ID. | 1078 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIaW |
Mutations | G/A |
Epitope Location | G9A |
HXB2 Location | G248A |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence |
Note | This variant was found in 6/80 HLA-B*57/58 subjects, but only in 17/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. It arises commonly and at no cost to the virus and is readily transmitted to persistence in restricting HLA negative subjects, is not correlated with compensations and increases viral infectivity. It is however, relatively ineffective as an escape with only partial loss of recognition. |
Variant ID. | 1079 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIdW |
Mutations | G/D |
Epitope Location | G9D |
HXB2 Location | G248D |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This variant was found in 1/68 HLA-B*57 subjects, and in 0/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. |
Variant ID. | 1080 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLpEQIGW |
Mutations | Q/P |
Epitope Location | Q5P |
HXB2 Location | Q244P |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | This variant was found in 1/80 HLA-B*57/58 subjects, and in no HLA-B*57/5801 negative subjects infected with Clade B HIV-1. |
Variant ID. | 1081 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIGW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | E: escape documented in this paper R: reversion RCR: replicative capacity reduced |
Epitope Subtype | B, C |
Variant Subtype | B, C |
Note | This T242N variant from Clade B consensus was found in 24/80 HLA-B*57/5801 subjects, but only in 1/107 HLA-B*57/5801 negative subject infected with Clade B HIV-1. T242N from Clade C consensus was found in 68/126 HLA-B*57/5801 subjects, but only in 2/132 HLA-B*57/5801 negative subjects infected with Clade C HIV-1. It was thought to revert quickly to TSTLQEQIAW in HLA-B*57/5801 negative subjects since viral replication is affected in these mutants. Amino acid T at position Gag242 is the helix stabilizing residue in p24 Gag. |
Martinez-Picado2006 Javier Martinez-Picado, Julia G. Prado, Elizabeth E. Fry, Katja Pfafferott, Alasdair Leslie, Senica Chetty, Christina Thobakgale, Isobel Honeyborne, Hayley Crawford, Philippa Matthews, Tilly Pillay, Christine Rousseau, James I. Mullins, Christian Brander, Bruce D. Walker, David I. Stuart, Photini Kiepiela, and Philip Goulder. Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1. J. Virol., 80(7):3617-3623, Apr 2006. PubMed ID: 16537629. Show all entries for this paper.
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