Found 2 matching records:
HXB2 Location | Gag(77-85) | Gag Epitope Map
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||||||||||||||||||||
Variants |
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Epitope Name | SL9 | |||||||||||||||||||||||
Species (MHC/HLA) | human(A*02:01) |
Showing all: 7 variant(s).
Variant ID. | 486 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTVATL |
Mutations | Y/F |
Epitope Location | Y3F |
HXB2 Location | Y79F |
Mutation Type | DHB: diminished HLA binding or increased off-rate E: escape documented in this paper |
Note | This variant was found in one patient and elicited <50% the response to the wt while it elicited strong response in another patient. Likely mechanism of escape was loss of HLA binding. |
Variant ID. | 487 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTVAvL |
Mutations | Y/F T/V |
Epitope Location | Y3F T8V |
HXB2 Location | Y79F T84V |
Mutation Type | E: escape documented in this paper TCR: TCR related mutation |
Note | This variant was found in two patients and elicited <50% the response to the wt in both patients. Likely mechanism of escape was loss of T cell recognition. |
Variant ID. | 488 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTVvTL |
Mutations | A/V |
Epitope Location | A7V |
HXB2 Location | A83V |
Mutation Type | IE: inferred escape |
Note | Variant found in one patient. Decline of CTL responses. |
Variant ID. | 489 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTiATL |
Mutations | Y/F V/I |
Epitope Location | Y3F V6I |
HXB2 Location | Y79F V82I |
Mutation Type | IE: inferred escape |
Note | Variant found in one patient. Decline of CTL responses. |
Variant ID. | 490 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiAvL |
Mutations | V/I T/V |
Epitope Location | V6I T8V |
HXB2 Location | V82I T84V |
Mutation Type | E: escape documented in this paper TCR: TCR related mutation |
Note | This variant was found in two patients and elicited <50% the response to the index peptide in both patients. The likely mechanism of escape was loss of T cell recognition. |
Variant ID. | 491 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLhNTVAvL |
Mutations | Y/H T/V |
Epitope Location | Y3H T8V |
HXB2 Location | Y79H T84V |
Mutation Type | DHB: diminished HLA binding or increased off-rate E: escape documented in this paper |
Note | This variant was found in one patient and elicited <25% the response to the wt in two patients. Likely mechanism of escape was loss of HLA binding. |
Variant ID. | 492 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTVAvL |
Mutations | T/V |
Epitope Location | T8V |
HXB2 Location | T84V |
Mutation Type | DHB: diminished HLA binding or increased off-rate E: escape documented in this paper |
Note | This variant was found in three patients and elicited <50% the response to the wt in two patients. Likely mechanism of escape was loss of HLA binding. |
Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.
HXB2 Location | Pol(464-472) | Pol Epitope Map
View variants at this location |
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Epitope |
ILKEPVHGV
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Epitope Alignment | ||||||||||||||||||||||
Variants |
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Epitope Name | IV9 | |||||||||||||||||||||||
Species (MHC/HLA) | human(A*02:01) |
Showing all: 7 variant(s).
Variant ID. | 493 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILKEPVHGa |
Mutations | V/A |
Epitope Location | V9A |
HXB2 Location | V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in all three patients, being the initial and the last variant in one of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 494 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILKEPiHGa |
Mutations | V/I V/A |
Epitope Location | V6I V9A |
HXB2 Location | V469I V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 495 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILrEPVHGV |
Mutations | K/R |
Epitope Location | K3R |
HXB2 Location | K466R |
Mutation Type | IE: inferred escape |
Note | This variant was found in two of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 496 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILKEPVHea |
Mutations | G/E V/A |
Epitope Location | G8E V9A |
HXB2 Location | G471E V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 497 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILKgPVHGa |
Mutations | E/G V/A |
Epitope Location | E4G V9A |
HXB2 Location | E467G V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 498 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILeEPVHGa |
Mutations | K/E V/A |
Epitope Location | K3E V9A |
HXB2 Location | K466E V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs. |
Variant ID. | 499 |
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Epitope Seq. | ILKEPVHGV |
Variant Seq. | ILrEPVHGa |
Mutations | K/R V/A |
Epitope Location | K3R V9A |
HXB2 Location | K466R V472A |
Mutation Type | IE: inferred escape |
Note | This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs. |
Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.
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