Found 1 matching record:
HXB2 Location | Gag(162-172) | Gag Epitope Map
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Epitope |
KAFSPEVIPMF
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Epitope Alignment | |||||||||||||||||||||||||
Variants |
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Epitope Name | KAFS | ||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*57:01, B*57:03) |
Showing all: 8 variant(s).
Variant ID. | 347 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KgFnPEVIPMF |
Mutations | A/G S/N |
Epitope Location | A2G S4N |
HXB2 Location | A163G S165N |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | A, AC |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clades A and AC. B*5701 CTL clones recognized this variant and displayed similar levels of lytic activity as against the wt at time 0 but 50% of activity at 24h later. This variant was presented more efficiently by B*5703 than by B*5701. The variant reacted with 100% of CTLs but failed to induce significant IFN-gamma secretion in 2 of the patients, indicating that this variant is unable to activate all downstream effector functions. However, it induced IFN-gamma in some patients' PBMCs. |
Variant ID. | 348 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAlSPEVIPMF |
Mutations | F/L |
Epitope Location | F3L |
HXB2 Location | F164L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | A |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clade A. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from 5 patients and did not induce secretion in PBMCs from 1 patient. |
Variant ID. | 349 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAFSPEVIPvF |
Mutations | M/V |
Epitope Location | M10V |
HXB2 Location | M171V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | A |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clade A. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from all patients. |
Variant ID. | 350 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAFnPEiIPMF |
Mutations | S/N V/I |
Epitope Location | S4N V7I |
HXB2 Location | S165N V168I |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | O group |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in group O. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from 4 patients and did not induce secretion in PBMCs from 2 patients. |
Variant ID. | 351 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAFSPEiIPMF |
Mutations | V/I |
Epitope Location | V7I |
HXB2 Location | V168I |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | AC |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clade A/C. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from all patients. |
Variant ID. | 352 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAFSqEVIPMF |
Mutations | P/Q |
Epitope Location | P5Q |
HXB2 Location | P166Q |
Mutation Type | DR: diminished response SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | AC |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clade A /C. It induced IFN-gamma production in 3/6 patients' PBMC but it demonstrated a diminished capacity to sensitize target cells for lysis. This variant was a weak ligand. |
Variant ID. | 353 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | rgFSPEVIPMF |
Mutations | K/R A/G |
Epitope Location | K1R A2G |
HXB2 Location | K162R A163G |
Mutation Type | OV: observed variant |
Note | Variant found in one patient in 10/11 clones. |
Variant ID. | 354 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | rgsSPEVIPMF |
Mutations | K/R A/G F/S |
Epitope Location | K1R A2G F3S |
HXB2 Location | K162R A163G F164S |
Mutation Type | OV: observed variant |
Note | Variant found in one patient in 1/11 clones. |
Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.
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