HIV molecular immunology database

 

Best-defined CTL/CD8+ Epitope Summary

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This is a list of best-defined HIV CTL/CD8+ epitopes as described by C. Brander and colleagues (review articles). This selective list of HIV epitopes is sometimes referred to as the "A list".

The protein, HXB2 location, host species and HLA restriction elements of the epitopes are provided. Identical entries are shown only once. The epitope sequence is a link to the database that will provide details of all epitopes containing that sequence.

Data last updated at 2013-10-03 12:37:55-06
Epitope Protein HXB2 location Subprotein HXB2 DNA Contig Subtype Species HLA
GELDRWEKI Gag 11-19 p17(11-19) 820..846   human B*4002
KIRLRPGGK Gag 18-26 p17(18-26) 841..867   human A*0301
IRLRPGGKK Gag 19-27 p17(19-27) 844..870 B human B*2705
RLRPGGKKK Gag 20-28 p17(20-28) 847..873   human A*0301
RLRPGGKKKY Gag 20-29 p17(20-29) 847..876 B human A*0301
RPGGKKKYKL Gag 22-31 p17(22-31) 853..882 B human B*5101
GGKKKYKLK Gag 24-32 p17(24-32) 859..885 B human B*0801
KYKLKHIVW Gag 28-36 p17(28-36) 871..897 B human A*2402
HLVWASREL Gag 33-41 p17(33-41) 886..912   human Cw*0804
LVWASRELERF Gag 34-44 p17(34-44) 889..921   human A30
WASRELERF Gag 36-44 p17(36-44) 895..921 B human B*3501
ELRSLYNTV Gag 74-82 p17(74-82) 1009..1035   human B*0801
RSLYNTVATLY Gag 76-86 p17(76-86) 1015..1047 B human A*3002, B58, B63
SLYNTVATL Gag 77-85 p17(77-85) 1018..1044 B human A*0201, A*0202, A*0205
SLYNTVATLY Gag 77-86 p17(77-86) 1018..1047 B human A*0201
LYNTVATL Gag 78-85 p17(78-85) 1021..1044   human Cw14
LYNTVATLY Gag 78-86 p17(78-86) 1021..1047   human A*2902, B*4403
TLYCVHQK Gag 84-91 p17(84-91) 1039..1062   human A*1101
IEIKDTKEAL Gag 92-101 p17(92-101) 1063..1092   human B*4001
NSSKVSQNY Gag 124-132 p17(124-132) 1159..1185 B human B*3501
VQNLQGQMV Gag 135-143 p24(3-11) 1192..1218   human B13
HQAISPRTL Gag 144-152 p24(12-20) 1219..1245   human B*1510
QAISPRTLNAW Gag 145-155 p24(13-23) 1222..1254 B human A*2501
ISPRTLNAW Gag 147-155 p24(15-23) 1228..1254   human B*5701, B63
SPRTLNAWV Gag 148-156 p24(16-24) 1231..1257   human B*0702
VKVIEEKAF Gag 156-164 p24(24-32) 1255..1281   human B*1503
EEKAFSPEV Gag 160-168 p24(28-36) 1267..1293   human B*4415
KAFSPEVI Gag 162-169 p24(30-37) 1273..1296 B human B*5703
KAFSPEVIPMF Gag 162-172 p24(30-40) 1273..1305 B human B*5701, B*5703, B63
FSPEVIPMF Gag 164-172 p24(32-40) 1279..1305   human B57
EVIPMFSAL Gag 167-175 p24(35-43) 1288..1314 B human A*2601, A*2602, A*2603
VIPMFSAL Gag 168-175 p24(36-43) 1291..1314 B human Cw*0102
SEGATPQDL Gag 176-184 p24(44-52) 1315..1341   human B*4001
TPQDLNTML Gag 180-188 p24(48-56) 1327..1353 B human B*0702, B*3910, B*4201, B*8101, Cw*0802
TPQDLNMML Gag 180-188 p24(48-56) 1327..1353 A human B53
TPYDINQML Gag 180-188 p24(48-56) 1327..1353 HIV-2 human B*5301
GHQAAMQML Gag 193-201 p24(61-69) 1366..1392 B human B*1510, B*3901
KETINEEAA Gag 202-210 p24(70-78) 1393..1419   human B*4002
ETINEEAAEW Gag 203-212 p24(71-80) 1396..1425   human A*2501
AEWDRVHPV Gag 210-218 p24(78-86) 1417..1443   human B*4002
HPVHAGPIA Gag 216-224 p24(84-92) 1435..1461   human B*3501, B7
GQMREPRGSDI Gag 226-236 p24(94-104) 1465..1497   human B13
TSTLQEQIGW Gag 240-249 p24(108-117) 1507..1536 B human B*5701, B*5801
NPPIPVGDIY Gag 253-262 p24(121-130) 1546..1575   human B*3501
PPIPVGDIY Gag 254-262 p24(122-130) 1549..1575 B human B*3501
EIYKRWII Gag 260-267 p24(128-135) 1567..1590 B human B*0801
RRWIQLGLQK Gag 263-272 p24(131-140) 1576..1605   human B*2703
KRWIILGLNK Gag 263-272 p24(131-140) 1576..1605 B human B*2705
GLNKIVRMY Gag 269-277 p24(137-145) 1594..1620 B human B*1501, B62
VRMYSPVSI Gag 274-282 p24(142-150) 1609..1635   human Cw18
RMYSPTSI Gag 275-282 p24(143-150) 1612..1635   human B*5201
YSPVSILDI Gag 277-285 p24(145-153) 1618..1644 CRF01_AE human Cw*0102
FRDYVDRFF Gag 293-301 p24(161-169) 1666..1692   human Cw18
FRDYVDRFYK Gag 293-302 p24(161-170) 1666..1695 B, D human B*1801
RDYVDRFFKTL Gag 294-304 p24(162-172) 1669..1701 A human A*2402
RDYVDRFYKTL Gag 294-304 p24(162-172) 1669..1701 B human B*4402
YVDRFYKTL Gag 296-304 p24(164-172) 1675..1701   human A*0207
YVDRFFKTL Gag 296-304 p24(164-172) 1675..1701   human B*1503, Cw*0303, Cw*0304
DRFYKTLRA Gag 298-306 p24(166-174) 1681..1707 B human B*1402
AEQASQDVKNW Gag 306-316 p24(174-184) 1705..1737 B human B*4402
AEQASQEVKNWM Gag 306-317 p24(174-185) 1705..1740   human Cw5
QASQEVKNW Gag 308-316 p24(176-184) 1711..1737 B human B*5301, B*5701, B*5801
VKNWMTETL Gag 313-321 p24(181-189) 1726..1752 B human B*4801
DCKTILKAL Gag 329-337 p24(197-205) 1774..1800 B human B*0801
ACQGVGGPGHK Gag 349-359 p24(217-227) 1834..1866   human A*1101
GPGHKARVL Gag 355-363 p24(223-231) 1852..1878 B human B*0702
AEAMSQVTNS Gag 364-373 p2p7p1p6(1-10) 1879..1908   human B*4501
CRAPRKKGC Gag 405-413 p2p7p1p6(42-50) 2002..2028   human B14
TERQANFL Gag 427-434 p2p7p1p6(64-71) 2068..2091   human B*4002
RQANFLGKI Gag 429-437 p2p7p1p6(66-74) 2074..2100 B human B*4801, B13
FLGKIWPSYK Gag 433-442 p2p7p1p6(70-79) 2086..2115   human A*0201
KELYPLTSL Gag 481-489 p2p7p1p6(118-126) 2230..2256   human B*4001
NSPTRREL Pol 24-31 Gag/Pol-TF(24-31) 2154..2177   human Cw*0102
ITLWQRPLV Pol 59-67 Protease(3-11) 2259..2285 A, B, D human A*6802, A*7401
DTVLEEWNL Pol 86-94 Protease(30-38) 2340..2366 D human A*6802
EEMNLPGRW Pol 90-98 Protease(34-42) 2352..2378   human B44
RQYDQILIEI Pol 113-122 Protease(57-66) 2421..2450   human B13
GKKAIGTVL Pol 124-132 Protease(68-76) 2454..2480   human B*1503
KAIGTVLV Pol 126-133 Protease(70-77) 2460..2483   human B57
LVGPTPVNI Pol 132-140 Protease(76-84) 2478..2504   human A*0201
TPVNIIGRNML Pol 136-146 Protease(80-90) 2490..2522   human B81
FPISPIETV Pol 155-163 Protease(99)-RT(8) 2547..2573 B human B*5401
IETVPVKL Pol 160-167 RT(5-12) 2562..2585   human B*4001
GPKVKQWPL Pol 173-181 RT(18-26) 2601..2627 B human B*0801
ALVEICTEM Pol 188-196 RT(33-41) 2646..2672 B human A*0201
ALVEICTEMEK Pol 188-198 RT(33-43) 2646..2678   human A*0301
KLVDFRELNK Pol 228-237 RT(73-82) 2766..2795   human A*0301
GIPHPAGLK Pol 248-256 RT(93-101) 2826..2852 B human A*0301
TVLDVGDAY Pol 262-270 RT(107-115) 2868..2894   human B*3501
VPLDEDFRKY Pol 273-282 RT(118-127) 2901..2930   human B*3501
YTAFTIPSV Pol 282-290 RT(127-135) 2928..2954   human A2
TAFTIPSI Pol 283-290 RT(128-135) 2931..2954   human B*5101
NETPGIRYQY Pol 292-301 RT(137-146) 2958..2987   human B18
IRYQYNVL Pol 297-304 RT(142-149) 2973..2996   human B*1401
LPQGWKGSPA Pol 304-313 RT(149-158) 2994..3023 B human B*5401
SPAIFQSSM Pol 311-319 RT(156-164) 3015..3041   human B7
AIFQSSMTK Pol 313-321 RT(158-166) 3021..3047 B human A*0301, A*1101
KQNPDIVIY Pol 328-336 RT(173-181) 3066..3092 B human A*3002, Cw*1202
NPEIVIYQY Pol 330-338 RT(175-183) 3072..3098   human B18
HPDIVIYQY Pol 330-338 RT(175-183) 3072..3098 B human B*3501
VIYQYMDDL Pol 334-342 RT(179-187) 3084..3110 B human A*0201
IEELRQHLL Pol 357-365 RT(202-210) 3153..3179 B human B*4001
IVLPEKDSW Pol 399-407 RT(244-252) 3279..3305   human B*5701
LVGKLNWASQIY Pol 415-426 RT(260-271) 3327..3362   human B*1501
KLNWASQIY Pol 418-426 RT(263-271) 3336..3362 B human A*3002
QIYPGIKVR Pol 424-432 RT(269-277) 3354..3380 B human A*0301
YPGIKVRQL Pol 426-434 RT(271-279) 3360..3386 B human B*4201
IPLTEEAEL Pol 448-456 RT(293-301) 3426..3452   human B*3501, B*5101
ILKEPVHGV Pol 464-472 RT(309-317) 3474..3500 B human A*0201
ILKEPVHGVY Pol 464-473 RT(309-318) 3474..3503 B human B*1501, Cw*1202
GQGQWTYQI Pol 488-496 RT(333-341) 3546..3572   human B13
IYQEPFKNLK Pol 496-505 RT(341-350) 3570..3599 B human A*1101
RMRGAHTNDV Pol 511-520 RT(356-365) 3615..3644   human A*3002
RMRGAHTNDVK Pol 511-521 RT(356-366) 3615..3647   human A*0301
IAMESIVIW Pol 530-538 RT(375-383) 3672..3698   human B*5801
PIQKETWETW Pol 547-556 RT(392-401) 3723..3752 B human A*3201
GAETFYVDGA Pol 591-600 RT(436-445) 3855..3884   human A*6802
ETFYVDGAANR Pol 593-603 RT(438-448) 3861..3893   human A66
ETKLGKAGY Pol 604-612 RT(449-457) 3894..3920   human A*2601
IVTDSQYAL Pol 650-658 RT(495-503) 4032..4058   human Cw*0802
VTDSQYALGI Pol 651-660 RT(496-505) 4035..4064   human B*1503
QIIEQLIKK Pol 675-683 RT(520-528) 4107..4133 B human A*1101
LFLDGIDKA Pol 715-723 RT(560)-Integrase(8) 4227..4253   human B81
LPPIVAKEI Pol 743-751 Integrase(28-36) 4311..4337   human B*4201
THLEGKIIL Pol 781-789 Integrase(66-74) 4425..4451   human B*1510
HVASGYIEA Pol 793-801 Integrase(78-86) 4461..4487 B human B*5401
IEAEVIPAET Pol 799-808 Integrase(84-93) 4479..4508 B human B*4002
HTDNGSNF Pol 829-836 Integrase(114-121) 4569..4592   human Cw5
STTVKAACWW Pol 838-847 Integrase(123-132) 4596..4625   human B57
IQQEFGIPY Pol 850-858 Integrase(135-143) 4632..4658   human B*1503
VRDQAEHL Pol 880-887 Integrase(165-172) 4722..4745   human Cw18
KTAVQMAVF Pol 888-896 Integrase(173-181) 4746..4772   human B*5701
AVFIHNFKRK Pol 894-903 Integrase(179-188) 4764..4793 B human A*0301, A*1101
FKRKGGIGGY Pol 900-909 Integrase(185-194) 4782..4811   human B*1503
KRKGGIGGY Pol 901-909 Integrase(186-194) 4785..4811   human B*2705
GERIVDII Pol 912-919 Integrase(197-204) 4818..4841 B human B*4002
IIATDIQTK Pol 918-926 Integrase(203-211) 4836..4862 B human A11
KIQNFRVYY Pol 934-942 Integrase(219-227) 4884..4910   human A*3002
VPRRKAKII Pol 975-983 Integrase(260-268) 5007..5033   human B42
RKAKIIRDY Pol 978-986 Integrase(263-271) 5016..5042   human B*1503
RIRTWKSLVK Vif 17-26   5089..5118 B human A*0301
HMYISKKAK Vif 28-36   5122..5148   human A*0301
ISKKAKGWF Vif 31-39   5131..5157   human B*5701
HPRVSSEVHI Vif 48-57   5182..5211   human B*0702
IPLGDAKLII Vif 57-66   5209..5238   human B51
WHLGHGVSI Vif 79-87   5275..5301   human B*1510
WHLGQGVSI Vif 79-87   5275..5301   human B*3801
LGHGVSIEW Vif 81-89   5281..5307   human B*5703
LADQLIHLHY Vif 102-111   5344..5373   human B*1801
KTKPPLPSVKK Vif 158-168   5512..5544   human A*0301
EAVRHFPRI Vpr 29-37   5643..5669   human B51
AVRHFPRIW Vpr 30-38   5646..5672   human B*5701
VRHFPRIWL Vpr 31-39   5649..5675   human B27
FPRIWLHGL Vpr 34-42   5658..5684   human B*0702, B*8101
ETYGDTWTGV Vpr 48-57   5700..5729   human A*6802
DTWAGVEAIIR Vpr 52-62   5712..5744   human A*6801
AIIRILQQL Vpr 59-67   5733..5759 B human A*0201
CCFHCQVC Tat 30-37   5918..5941   human Cw12
FQTKGLGISY Tat 38-47   5942..5971   human B*1503
ITKGLGISYGR Tat 39-49   5945..5977   human A*6801
KAVRLIKFLY Rev 14-23   6009..6038 B human B*5701, B*5801, B63
QAVRIIKILY Rev 14-23   6009..6038 C human B*5703
ERILSTYLGR Rev 57-66   8471..8500   human A*0301
RPAEPVPLQL Rev 66-75   8498..8527   human B7
SAEPVPLQL Rev 67-75   8501..8527 B human Cw*0501
YRLGVGALI Vpu 5-13   6074..6100 C human Cw18
EYRKILRQR Vpu 29-37   6146..6172   human A*3303
RVKEKYQHL gp160 2-10 gp120(2-10) 6228..6254   human B*0801
AENLWVTVY gp160 31-39 gp120(31-39) 6315..6341   human B*1801, B44
AENLWVTVYY gp160 31-40 gp120(31-40) 6315..6344   human B*4402
TVYYGVPVWK gp160 37-46 gp120(37-46) 6333..6362 B human A*0301
VPVWKEATTT gp160 42-51 gp120(42-51) 6348..6377   human B*5501
VPVWKEATTTL gp160 42-52 gp120(42-52) 6348..6380   human B*3501
LFCASDAKAY gp160 52-61 gp120(52-61) 6378..6407 B human A*2402
KAYETEVHNVW gp160 59-69 gp120(59-69) 6399..6431   human B58
YETEVHNVW gp160 61-69 gp120(61-69) 6405..6431   human B*1801
DPNPQEVVL gp160 78-86 gp120(78-86) 6456..6482   human B*3501
MHEDIISLW gp160 104-112 gp120(104-112) 6534..6560   human B*3801
SVITQACPK gp160 199-207 gp120(199-207) 6819..6845   human A*1101
SFEPIPIHY gp160 209-217 gp120(209-217) 6849..6875 B human A*2902
CAPAGFAIL gp160 218-226 gp120(218-226) 6876..6902   human Cw1
RPNNNTRKSI gp160 298-307 gp120(298-307) 7116..7145 B human B*0702
HIGPGRAFY gp160 310-318 gp120(310-318) 7152..7178   human A*3002
RGPGRAFVTI gp160 311-320 gp120(311-320) 7155..7184   human A*0201
EIIGDIRQAY gp160 321-330 gp120(321-330) 7185..7214   human A*2501
SFNCGGEFF gp160 375-383 gp120(375-383) 7347..7373 B human B*1516, Cw*0401
LPCRIKQII gp160 416-424 gp120(416-424) 7470..7496 B human B*5101
RIKQIINMW gp160 419-427 gp120(419-427) 7479..7505 B human A*3201
RAIEAQQHL gp160 557-565 gp41(46-54) 7893..7919   human Cw*0304, Cw15
RAIEAQQHM gp160 557-565 gp41(46-54) 7893..7919   human Cw8
QTRVLAIERYL gp160 577-587 gp41(66-76) 7953..7985 C human B*5802
ERYLKDQQL gp160 584-592 gp41(73-81) 7974..8000   human B*1402
RYLKDQQLL gp160 585-593 gp41(74-82) 7977..8003 B human A*2402, A23
YLKDQQLL gp160 586-593 gp41(75-82) 7980..8003   human B*0801
TAVPWNASW gp160 606-614 gp41(95-103) 8040..8066 B human B*3501
VFAVLSIVNR gp160 698-707 gp41(187-196) 8316..8345   human A*3303
IVNRNRQGY gp160 704-712 gp41(193-201) 8334..8360 B human A*3002
RLRDLLLIVTR gp160 770-780 gp41(259-269) 8532..8564 B human A*0301, A*3101
IVTRIVELL gp160 777-785 gp41(266-274) 8553..8579 B human A*6802
GRRGWEALKY gp160 786-795 gp41(275-284) 8580..8609 B human B*2705
RRGWEVLKY gp160 787-795 gp41(276-284) 8583..8609   human A*0101
KYCWNLLQY gp160 794-802 gp41(283-291) 8604..8630 B human A*3002
QELKNSAVSL gp160 805-814 gp41(294-303) 8637..8666 B human B*4001
SLLNATDIAV gp160 813-822 gp41(302-311) 8661..8690 B human A*0201
LLNATDIAV gp160 814-822 gp41(303-311) 8664..8690 B human A*0201
EVAQRAYR gp160 831-838 gp41(320-327) 8715..8738   human A*3303
IPRRIRQGL gp160 843-851 gp41(332-340) 8751..8777 B human B*0702
RIRQGLERA gp160 846-854 gp41(335-343) 8760..8786   human A*0205
RQGLERALL gp160 848-856 gp41(337-345) 8766..8792   human B8
WPTVRERM Nef 13-20   8833..8856 B human B*0801
RMRRAEPAA Nef 19-27   8851..8877   human B62
LEKHGAITS Nef 37-45   8905..8931   human B*4001, B50
FPVTPQVPL Nef 68-76   8998..9024   human B*0702
FPVTPQVPLR Nef 68-77   8998..9027 B human B*0702
TPQVPLRPM Nef 71-79   9007..9033 B human B*0702
RPQVPLRPM Nef 71-79   9007..9033   human B*4201, B*4202
RPQVPLRPMTY Nef 71-81   9007..9039 B human B35
QVPLRPMTYK Nef 73-82   9013..9042 B human A*0301, A*1101
VPLRPMTY Nef 74-81   9016..9039 B human B*3501
PLRPMTYK Nef 75-82   9019..9042 B human A*1101
LRPMTYKAA Nef 76-84   9022..9048 B human B*2703
RPMTYKAAL Nef 77-85   9025..9051 B human B*0702
KAAFDLSFF Nef 82-90   9040..9066   human B*5703, B*5801
KAAVDLSHFL Nef 82-91   9040..9069   human Cw8
GAFDLSFFL Nef 83-91   9043..9069   human A*0205
AAFDLSFFL Nef 83-91   9043..9069   human B*5703
AAVDLSHFL Nef 83-91   9043..9069 B human Cw*0802
AALDLSHFL Nef 83-91   9043..9069   human Cw3
AVDLSHFLK Nef 84-92   9046..9072 B human A*0301, A*1101
FLKEKGGL Nef 90-97   9064..9087 B human B*0801
KEKGGLEGL Nef 92-100   9070..9096 B human B*4001, B*4002
RRQDILDLWI Nef 105-114   9109..9138 B human B*2705
RRQDILDLWVY Nef 105-115   9109..9141   human B18
KRQEILDLWVY Nef 105-115   9109..9141   human Cw7
RQDILDLWI Nef 106-114   9112..9138   human B13
RQDILDLWV Nef 106-114   9112..9138   human B*1302
HTQGYFPDW Nef 116-124   9142..9168   human B*5703, B*5801, B57
TQGYFPDWQNY Nef 117-127   9145..9177 B human B*1501
YFPDWQNYT Nef 120-128   9154..9180 B human A29, B*3501, Cw6
FPDWQNYTP Nef 121-129   9157..9183 B human B*5401
YTPGPGIRY Nef 127-135   9175..9201   human B57, B63
TPGPGVRYPL Nef 128-137   9178..9207 B human B*0702, B*4201, B*4202
TRYPLTFGW Nef 133-141   9193..9219   human A33
RYPLTFGW Nef 134-141   9196..9219 B human A*2402
YPLTFGWCY Nef 135-143   9199..9225 B human B*1801, B*5301
YPLTFGWCF Nef 135-143   9199..9225   human B53
PLTFGWCYKL Nef 136-145   9202..9231 B human A*0201
LTFGWCFKL Nef 137-145   9205..9231   human B57, B63
VLEWRFDSRL Nef 180-189   9334..9363 B human A*0201
WRFDSRLAF Nef 183-191   9343..9369   human B*1503
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