HIV molecular immunology database

Best-defined CTL/CD8+ Epitope Summary

Download Best-defined CTL/CD8+ epitope summary.

This is a list of best-defined HIV CTL/CD8+ epitopes as described by Frahm, Linde & Brander (review article [PDF]). This selective list of HIV epitopes is sometimes referred to as the "A list".

The protein, HXB2 location, host species and HLA restriction elements of the epitopes are provided. Identical entries are shown only once. The epitope sequence is a link to the database that will provide details of all epitopes containing that sequence.

Epitope Protein HXB2 Location Subtype Species HLA
GELDRWEKI p17 11-19 human B*4002
KIRLRPGGK p17 18-26 human A*0301
IRLRPGGKK p17 19-27 B human B*2705
RLRPGGKKK p17 20-28 human A*0301
RLRPGGKKKY p17 20-29 B human A*0301
GGKKKYKLK p17 24-32 B human B*0801
KYKLKHIVW p17 28-36 B human A*2402
HLVWASREL p17 33-41 human Cw*0804
LVWRELERF p17 34-44 human A30
WASRELERF p17 36-44 B human B*3501
ELRSLYNTV p17 74-82 human B*0801
RSLYNTVATLY p17 76-86 B human A*3002, B58, B63
SLYNTVATL p17 77-85 B human A*0201, A*0202, A*0205
LYNTVATL p17 78-85 human Cw14
LYNTVATLY p17 78-86 human A*2902, B*4403
TLYCVHQK p17 84-91 human A*1101
IEIKDTKEAL p17 92-101 human B*4001
NSSKVSQNY p17 124-132 B human B*3501
VQNLQGQMV p24 3-11 human B13
HQAISPRTL p24 12-20 human B*1510
QAISPRTLNAW p24 13-23 B human A*2501
ISPRTLNAW p24 15-23 human B*5701, B63
SPRTLNAWV p24 16-24 human B*0702
VKVIEEKAF p24 24-32 human B*1503
EEKAFSPEV p24 28-36 human B*4415
KAFSPEVI p24 30-37 B human B*5703
KAFSPEVIPMF p24 30-40 B human B*5701, B*5703, B63
FSPEVIPMF p24 32-40 human B57
EVIPMFSAL p24 35-43 B human A*2601
VIPMFSAL p24 36-43 B human Cw*0102
SEGATPQDL p24 44-52 human B*4001
TPQDLNTML p24 48-56 B human B*0702, B*3910, B*4201, B*8101, Cw*0802
TPYDINQML p24 48-56 HIV-2 human B*5301
GHQAAMQML p24 61-69 B human B*1510, B*3901
KETINEEAA p24 70-78 human B*4002
ETINEEAAEW p24 71-80 human A*2501
AEWDRVHPV p24 78-86 human B*4002
HPVHAGPIA p24 84-92 human B7
GQMREPRGSDI p24 94-104 human B13
TSTLQEQIGW p24 108-117 B human B*5701, B*5801
TSTVEEQQIW p24 108-117 HIV-2 human B*5801
PPIPVGDIY p24 122-130 B human B*3501
NPVPVGNIY p24 122-130 human B*3501
EIYKRWII p24 128-135 B human B*0801
RRWIQLGLQK p24 131-140 human B*2703
KRWIILGLNK p24 131-140 B human B*2705
GLNKIVRMY p24 137-145 B human B*1501
VRMYSPVSI p24 142-150 human Cw18
RMYSPTSI p24 143-150 human B*5201
FRDYVDRFF p24 161-169 human Cw18
FRDYVDRFYK p24 161-170 B, D human B*1801
RDYVDRFFKTL p24 162-172 A human A*2402
RDYVDRFYKTL p24 162-172 B human B*4402
YVDRFYKTL p24 164-172 human A*0207
YVDRFFKTL p24 164-172 human B*1503, Cw*0303, Cw*0304
DRFYKTLRA p24 166-174 B human B*1402
AEQASQDVKNW p24 174-184 B human B*4402
AEQASQEVKNWM p24 174-185 human Cw5
QASQEVKNW p24 176-184 B human B*5301, B*5701
DCKTILKAL p24 197-205 B human B*0801
ACQGVGGPGHK p24 217-227 human A*1101
GPGHKARVL p24 223-231 B B*0702
AEAMSQVTNS p2p7p1p6 1-10 human B*4501
CRAPRKKGC p2p7p1p6 42-50 human B14
TERQANFL p2p7p1p6 64-71 human B*4002
RQANFLGKI p2p7p1p6 66-74 human B13
FLGKIWPSYK p2p7p1p6 70-79 human A*0201
KELYPLTSL p2p7p1p6 118-126 human B*4001
NSPTRREL Gag_Pol_TF 24-31 human Cw*0102
ITLWQRPLV Protease 3-11 A, B, D human A*6802, A*7401
DTVLEEWNL Protease 30-38 D human A*6802
EEMNLPGRW Protease 34-42 human B44
RQYDQILIEI Protease 57-66 human B13
RQYDQIPIEI Protease 57-66 human  
GKKAIGTVL Protease 68-76 human B*1503
KAIGTVLV Protease 70-77 human B57
LVGPTPVNI Protease 76-84 human A*0201
TPVNIIGRNML Protease 80-90 human B81
IETVPVKL RT 5-12 human B*4001
GPKVKQWPL RT 18-26 B human B*0801
ALVEICTEM RT 33-41 B human A*0201
ALVEICTEMEK RT 33-43 human A*0301
EKEGKISKI RT 42-50 B human B*5101
KLVDFRELNK RT 73-82 human A*0301
GIPHPAGLK RT 93-101 B human A*0301
TVLDVGDAY RT 107-115 B*3501
VPLDEDFRKY RT 118-127 human B*3501
YTAFTIPSV RT 127-135 human A2
TAFTIPSI RT 128-135 human B*5101
NETPGIRYQY RT 137-146 human B18
IRYQYNVL RT 142-149 human B*1401
SPAIFQSSM RT 156-164 human B7
AIFQSSMTK RT 158-166 B human A*0301, A*1101
KQNPDIVIY RT 173-181 B human A*3002
NPDIVIYQY RT 175-183 human B*3501
HPDIVIYQY RT 175-183 B human B*3501
NPEIVIYQY RT 175-183 human B18
VIYQYMDDL RT 179-187 B human A*0201
IEELRQHLL RT 202-210 B human B*4001
IVLPEKDSW RT 244-252 human B*5701
LVGKLNWASQIY RT 260-271 human B*1501
KLNWASQIY RT 263-271 B human A*3002
QIYPGIKVR RT 269-277 B human A*0301
YPGIKVRQL RT 271-279 B human B*4201
ILKEPVHGV RT 309-317 B human A*0201
ILKEPVHGVY RT 309-318 B human B*1501
GQGQWTYQI RT 333-341 human B13
IYQEPFKNLK RT 341-350 B human A*1101
RMRGAHTNDV RT 356-365 human A*3002
RMRGAHTNDVK RT 356-366 human A*0301
IAMESIVIW RT 375-383 human B*5801
PIQKETWETW RT 392-401 B human A*3201
GAETFYVDGA RT 436-445 human A*6802
ETFYVDGAANR RT 438-448 human A66
ETKLGKAGY RT 449-457 human A*2601
IVTDSQYAL RT 495-503 human Cw*0802
VTDSQYALGI RT 496-505 human B*1503
QIIEQLIKK RT 520-528 B human A*1101
LFLDGIDKA RT-Integrase 560-8 human B81
LPPIVAKEI Integrase 28-36 human B42
THLEGKIIL Integrase 66-74 human B*1510
STTVKAACWW Integrase 123-132 human B57
IQQEFGIPY Integrase 135-143 human B*1503
VRDQAEHL Integrase 165-172 human Cw18
KTAVQMAVF Integrase 173-181 human B*5701
AVFIHNFKRK Integrase 179-188 B human A*0301, A*1101
FKRKGGIGGY Integrase 185-194 human B*1503
IIATDIQTK Integrase 203-211 human  
KIQNFRVYY Integrase 219-227 human A*3002
VPRRKAKII Integrase 260-268 human B42
RKAKIIRDY Integrase 263-271 human B*1503
RIRTWKSLVK Vif 17-26 B human A*0301
HMYISKKAK Vif 28-36 human A*0301
ISKKAKGWF Vif 31-39 human B*5701
HPRVSSEVHI Vif 48-57 human B*0702
IPLGDAKLII Vif 57-66 human B51
WHLGHVSI Vif 79-87 human B*1510
WHLGQGVSI Vif 79-87 human B*3801
LADQLIHLHY Vif 102-111 human B*1801
KTKPPLPSVKK Vif 158-168 human A*0301
EAVRHFPRI Vpr 29-37 human B51
AVRHFPRIW Vpr 30-38 human B*5701
VRHFPRIWL Vpr 31-39 human B27
FPRIWLHGL Vpr 34-42 human B*0702, B*8101
ETYGDTWTGV Vpr 48-57 human A*6802
DTWAGVEAIIR Vpr 52-62 human A*6801
AIIRILQQL Vpr 59-67 B human A*0201
EPVDPRLEPW Tat 2-11 B human B*5301, B58
CCFHCQVC Tat 30-37 human Cw12
FQTKGLGISY Tat 38-47 human B*1503
ITKGLGISYGR Tat 39-49 human A*6801
KAVRLIKFLY Rev 14-23 B human B*5701, B*5801, B63
ERILSTYLGR Rev 57-66 human A*0301
RPAEPVPLQL Rev 66-75 human B7
SAEPVPLQL Rev 67-75 B human Cw*0501
EYRKILRQR Vpu 29-37 human A*3303
RVKEKYQHL gp160 2-10 human B*0801
AENLWVTVY gp160 31-39 human B*1801, B44
AENLWVTVYY gp160 31-40 human B*4402
TVYYGVPVWK gp160 37-46 B human A*0301
VPVWKEATTT gp160 42-51 human B*5501
VPVWKEATTTL gp160 42-52 human B*3501
LFCASDAKAY gp160 52-61 B human A*2402
KAYETEVHNVW gp160 59-69 human B58
YETEVHNVW gp160 61-69 human B*1801
DPNPQEVVL gp160 78-86 human B*3501
MHEDIISLW gp160 104-112 human B*3801
SVITQACPK gp160 199-207 human A*1101
SFEPIPIHY gp160 209-217 B human A*2902
RPNNNTRKSI gp160 298-307 B human B*0702
HIGPGRAFY gp160 310-318 human A*3002
RGPGRAFVTI gp160 311-320 human A*0201
SFNCGGEFF gp160 375-383 B human B*1516, Cw*0401
LPCRIKQII gp160 416-424 B human B*5101
RIKQIINMW gp160 419-427 B human A*3201
YRLGVGALI gp160 511-519 human Cw18
RAIEAQQHL gp160 557-565 human Cw*0304, Cw15
RAIEAQQHM gp160 557-565 human Cw8
ERYLKDQQL gp160 584-592 human B*1402
RYLKDQQLL gp160 585-593 B human A*2402, A23
YLKDQQLL gp160 586-593 human B*0801
TAVPWNASW gp160 606-614 B human B*3501
VFAVLSIVNR gp160 698-707 human A*3303
EIIFDIRQAY gp160 703-712 human A*2501
IVNRNRQGY gp160 704-712 B human A*3002
RLRDLLLIVTR gp160 770-780 B human A*0301, A*3101
IVTRIVELL gp160 777-785 B human A*6802
GRRGWEALKY gp160 786-795 B human B*2705
RRGWEVLKY gp160 787-795 human A*0101
KYCWNLLQY gp160 794-802 B human A*3002
QELKNSAVSL gp160 805-814 B human B*4001
SLLNATDIAV gp160 813-822 B human A*0201
EVAQRAYR gp160 831-838 human A*3303
IPRRIRQGL gp160 843-851 B human B*0702
RIRQGLERA gp160 846-854 human A*0205
RQGLERALL gp160 848-856 human B8
WPTVRERM Nef 13-20 B human B*0801
RMRRAEPAA Nef 19-27 human B62
LEKHGAITS Nef 37-45 human B*4001, B50
FPVTPQVPL Nef 68-76 human B*0702
FPVTPQVPLR Nef 68-77 B human B*0702
TPQVPLRPM Nef 71-79 B human B*0702
RPQVPLRPM Nef 71-79 human B*4201
QVPLRPMTYK Nef 73-82 B human A*0301, A*1101
VPLRPMTY Nef 74-81 B human B*3501
PLRPMTYK Nef 75-82 B human A*1101
RPMTYKAAL Nef 77-85 B human B*0702
KAAVDLSHFL Nef 82-91 human Cw8
GAFDLSFFL Nef 83-91 human A*0205, Cw*0802
AAVDLSHFL Nef 83-91 B human Cw*0802
AALDLSHFL Nef 83-91 human Cw3
AVDLSHFLK Nef 84-92 B human A*0301, A*1101
FLKEKGGL Nef 90-97 B human B*0801
KEKGGLEGL Nef 92-100 B human B*4001, B*4002
RRQDILDLWI Nef 105-114 B human B*2705
RRQDILDLWVY Nef 105-115 human B18
KRQEILDLWVY Nef 105-115 human Cw7
RRQDILDLWIY Nef 105-115 human Cw7
RQDILDLWV Nef 106-114 human B13
RQDILDLWI Nef 106-114 human B13
RQDILDLWIY Nef 106-115 B B*0702
HTQGYFPDW Nef 116-124 human B57
HTQGYFPDWQ Nef 116-125 human B*5701
TQGYFPDWQNY Nef 117-127 B human B*1501
YFPDWQNYT Nef 120-128 B human A29, B*3701, B*5701, Cw6
YTPGPGIRY Nef 127-135 human B57, B63
TPGPGVRYPL Nef 128-137 B human B*0702, B*4201
TRYPLTFGW Nef 133-141 human A33
RYPLTFGW Nef 134-141 B human A*2402
YPLTFGWCY Nef 135-143 B human B*1801, B*5301
YPLTFGWCF Nef 135-143 human B53
PLTFGWCYKL Nef 136-145 B human A*0201
LTFGWCFKL Nef 137-145 human B57, B63
VLEWRFDSRL Nef 180-189 B human A*0201
WRFDSRLAF Nef 183-191 human B*1503
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