HIV molecular immunology database

 

About the HIV Molecular Immunology Database

Background

The HIV Molecular Immunology Database is an annotated, searchable collection of HIV-1 cytotoxic and helper T-cell epitopes and antibody binding sites. The goal of this database is to provide a comprehensive listing of defined HIV epitopes. These data are also printed in the HIV Molecular Immunology compendium, which is updated yearly and provided by online download.

The HIV Molecular Immunology Database and Compendium are funded by the Division of AIDS, National Institute of Allergy and Infectious Diseases, through an interagency agreement with the U.S. Department of Energy.

We are grateful to the external database editors who help us with suggestions to improve this website and compendium.

About this Database

HIV Molecular Immunology is a companion volume to Human Retroviruses and AIDS Genetic Sequence Compendium. This publication is the published version of this website. The web interface for this relational database has many search options, as well as interactive tools to help immunologists design reagents and interpret their results. For information about referencing this database in publications, please see How to Cite the HIV Immunology Database.

The data included in this database are extracted from the HIV immunology literature. HIV-specific B-cell and T-cell responses are summarized and annotated. Immunological responses are divided into three sections: CTL (CD8+), T helper (CD4+), and antibody. Within these sections, defined epitopes are organized by protein and binding sites within each protein. We include human responses to natural HIV infections, as well as vaccine studies in a range of animal models and human trials. Only responses to HIV-1 and HIV-2 are included. Responses that are not specifically defined, such as responses to whole proteins or monoclonal antibody responses to discontinuous epitopes, are summarized at the end of each protein sub-section. Studies describing general HIV responses to the virus, but not to any specific protein, are included at the end of each section.

The annotation includes information such as cross-reactivity, escape mutations, antibody sequence, TCR usage, functional domains that overlap with an epitope, immune response associations with rates of progression and therapy, and how specific epitopes were experimentally defined. Basic information such as HLA specificities for T-cell epitopes, isotypes of monoclonal antibodies, and epitope sequences are included whenever possible. All studies that we can find that incorporate the use of a specific monoclonal antibody are included in the entry for that antibody. A single T-cell epitope can have multiple entries, generally one entry per study.

Additional information about this database can be found in Frequently-Asked Questions. Comments are always welcome, and can be sent to immuno@lanl.gov.

Database statistics

HIV Immunology database record counts as of 23 July 2014, 18:19 MDT.

Database Records References
CTL, CD8+ 7828 1198
T-helper, CD4+ 1406 364
Antibodies 2727 1852
Total bibliography 3267

The "total bibliography" count is less than the sum of the "references" column because some references appear in more than one section of the database.

Last modified: Tue Dec 6 08:59:13 MST 2005

Questions or comments? Contact us at immuno@lanl.gov
 
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