HIV molecular immunology database

 

Study 1: HLA Typing and Epitope Mapping

Introduction

This website contains supplemental data tables and figures for

Consistent CTL targeting of immunodominant regions in HIV across different ethnicities. J. Virol. 78(5), 2004. (Data kindly provided prior to publication by Dr. Frahm and Dr. Brander. This work was funded by NIH contract N01-Al-15422, HLA typing and CTL epitope mapping to guide HIV vaccine development.)

N. Frahm1, B. T. Korber7, C. M. Adams1, J. J. Szinger7, R. Draenert1, M. M. Addo1, M. E. Feeney1, K. Yusim7, K. Sango1, N. V. Brown1, D. Sen Gupta1, A. Piechocka-Trocha1, T. Simonis2, F. M. Marincola2, A. G. Wurcel1,3, D. R. Stone3, C. J. Russell4, P. Adolf4, D. Cohen4, T. Roach5, A. St. John5, A. Khatri6, K. Davies8, J. Mullins8, P. J. R. Goulder1, B. D. Walker1, C. Brander1.

1Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA, 02129, 2Clinical Center NIH, Bethesda, MD, 3Lemuel Shattuck Hospital, Boston, MA, 4Fenway Health Center, Boston, MA, 5Queen Elizabeth Hospital, Bridgetown, Barbados, 6Endocrine Unit, Massachusetts General Hospital, Charlestown, MA, 7Los Alamos National Laboratory, Los Alamos, NM, and 8Department of Microbiology, University of Washington, Seattle, WA, USA.

Peptides

Peptide data: a list of the test peptides in the study.

Subjects

Subject data: a list of the subjects in this study. Includes reactivity summary.

Reactivity

Reaction data: a list of which peptides showed a reaction for which subject. Includes SFC data.

Reaction map: Maps of peptide reactivity against the proteins used for peptide design, aligned to HXB2. We listed the most common HLA molecules for this set, and color coded them on the map. If appropriate anchor residues were present for these HLA molecules in the protein sequence, for the most common HLA molecules, we color coded the potential epitope on an aligned set of sequences from the map. We highlight anchors with spacing for a 9-mer epitope, as the picture gets too busy otherwise.

Last modified: Tue Mar 23 14:02:54 MST 2004

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