HLA Comparison

NOTICE: Experimental software

This software is still under development and has not been fully tested. Please let us know what you think at immuno@lanl.gov.

This tool takes two series of tab-delimited HLA types and compares the HLA frequencies in the two sets. For more information, see details below, and try Sample Input.

Input

Population 1
Paste your HLA data here Sample Input
or browse to select a file

Population 2
Paste your HLA data here
or browse to select a file

Options

Compare what class of HLA types?
Sort the output by

Details

Input Format

This program expects a list of HLA Class-I alleles. Each line of the input should be a unique patient ID followed by a list of HLAs, all separated by spaces or tabs. Missing data may be omitted, or indicated by a dash '-'.

HLA frequency

HLA frequences can be counted two different ways, which differ in how homozygous alleles are counted.

Population: Frequencies of HLA type per person. Homozygous HLAs are counted once.
Allele: Frequencies of HLA type per allele. Homozygous HLAs are counted twice.

HLA 2/4 digit conversion

HLA type are reported with various resolutions (2, 4 or more digits). This tools provied three options for handling this.

Leave HLAs as presented: The HLA type are left unchanged and each distinct type is counted separately.
4-digit HLA comparison: Silent mutations are ignored; HLA types with more than 4 digits precision are truncated. HLA type with 2 digits are left unchanged.
2-digit HLA comparison: All HLA type are converted to 2 digits. The conversion serotype information if available or else the 2-digit HLA family.