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HXB2 Location | Env(32-44) gp120(32-44) DNA(6318..6356) |
Env Epitope Map |
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Author Location | gp120(39-51) | |
Epitope |
EQLWVTVYYGVPV
|
Epitope Alignment
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Species (MHC/HLA) | mouse(H-2bxk) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | peptide |
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Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.
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