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HXB2 Location | HIV-2 proteins DNA(7350..7373) |
HIV-2 proteins Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
TNCRGEFL
|
Epitope Alignment |
Subtype | HIV-2 | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-2 infection | |
Country | Gambia, Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HIV exposed persistently seronegative (HEPS), HIV-2 |
Johnson1993 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Recognition of a Highly Conserved Region of Human Immunodeficiency Virus Type 1 gp120 by an HLA-Cw4-Restricted Cytotoxic T-Lymphocyte Clone. J. Virol., 67:438-445, 1993. The epitope sequence FNCGGEFF stimulates CTL response; the natural variants FNCRGEFF (SF2), TNCRGEFL (ROD) and LNCGGEFF (NDK) do not serve as epitopes. This was the first report of an HIV antigen specific target cells restricted by an HLA-C molecule, Cw4. PubMed ID: 7677956. Show all entries for this paper.
Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.
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