Found 37 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | AL9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | rate of progression, escape, mutation acquisition |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | Nef-AL9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, United States | |
Experimental methods | Chromium-release assay | |
Keywords | class I down-regulation by Nef |
Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91 HXB2) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | Viet Nam | |
Experimental methods | HLA binding | |
Keywords | subtype comparisons, computational prediction, escape, variant cross-reactivity, vaccine antigen design |
Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | AL9 | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | P-1031: A*02, A*30, B*13, B*18, C*01, C*05; M-1002: A*30, B*18, B*40, C*02, C*05; M-1005: A*02, A*32, B*07, B*40, C*03, C*07; P-1026: A*24, A*32, B*07, B*18, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | responses in children, mother-to-infant transmission, escape, characterizing CD8+ T cells, viral fitness and/or reversion |
Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91 BRU) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation | |
Keywords | vaccine-induced immune responses, variant cross-reactivity |
Vaccine type | lipopeptide |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | Env, Gag, Nef |
Adjuvant | QS21 |
Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91 BRU) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | A1, B, CRF02_AG | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational prediction, variant cross-reactivity, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | A68-AL(Nef) | |
Species (MHC/HLA) | human(A68) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance, novel epitope |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*14) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*14:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | optimal epitope |
MiguelesPerCom2015 S. A. Migueles. Personal communication, 2015. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*14:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance, optimal epitope, novel epitope, A-list |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
MiguelesPerCom2015 S. A. Migueles. Personal communication, 2015. Show all entries for this paper.
Silva-Arrieta2022 Sandra Silva-Arrieta, Tuixent Escriba, Anuska Llano, Katherine A. Belobrajdic, Elizabeth-Sharon David-Fung, and Christian Brander. HIV Epitope A-list: The 2021 Update. In Elizabeth-Sharon David-Fung, Bette T. M. Korber, Christian Brander, Dan Barouch, Rob de Boer, Barton. F Haynes, Koup Richard, John. P Moore, Bruce. D Walker, and David. I Watkins, editors, HIV Epitope A-list: The 2021 Update. page . Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 2022. URL: https://www.hiv.lanl.gov/content/sequence/HIV/REVIEWS/reviews.html. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*58) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance, novel epitope |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*58) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*58) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance, optimal epitope, novel epitope, A-list |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
MiguelesPerCom2015 S. A. Migueles. Personal communication, 2015. Show all entries for this paper.
Silva-Arrieta2022 Sandra Silva-Arrieta, Tuixent Escriba, Anuska Llano, Katherine A. Belobrajdic, Elizabeth-Sharon David-Fung, and Christian Brander. HIV Epitope A-list: The 2021 Update. In Elizabeth-Sharon David-Fung, Bette T. M. Korber, Christian Brander, Dan Barouch, Rob de Boer, Barton. F Haynes, Koup Richard, John. P Moore, Bruce. D Walker, and David. I Watkins, editors, HIV Epitope A-list: The 2021 Update. page . Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 2022. URL: https://www.hiv.lanl.gov/content/sequence/HIV/REVIEWS/reviews.html. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*58) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | optimal epitope |
MiguelesPerCom2015 S. A. Migueles. Personal communication, 2015. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B60, B62, C*08:02, Cw8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A23, B44, B62, Cw3, Cw4; A1, A3, B14, B7, C*07:02, C*08:02; A*02:01, A31, B44, B60, C*16, Cw3; A1, A1, B14, B8, Cw7, Cw8 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection, early treatment |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | AL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B62, Cw8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection, assay or method development, mutation acquisition |
Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(B*81) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CTL suppression of replication | |
Keywords | class I down-regulation by Nef |
Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | LTNP/EC-10: A*11, A*30, B*15, B*52, C*03, C*12; LTNP/EC-11: A*33, A*68, B*14, B*15, C*02, C*08 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, immunodominance |
Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | AL9 | |
Subtype | B | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | acute/early infection |
Malhotra2009 U. Malhotra, J. Nolin, H. Horton, F. Li, L. Corey, J. I. Mullins, and M. J. McElrath. Functional Properties and Epitope Characteristics of T-Cells Recognizing Natural HIV-1 Variants. Vaccine, 27(48):6678-6687, 12 Nov 2009. PubMed ID: 19747576. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91 LAI) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*08:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*08:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | optimal epitope |
MiguelesPerCom2015 S. A. Migueles. Personal communication, 2015. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Species (MHC/HLA) | human(C*17) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(83-91) | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | AL9 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | Cw3-AL9 | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | immunodominance, acute/early infection, chronic infection |
Streeck2009a Hendrik Streeck, Jonathan S. Jolin, Ying Qi, Bader Yassine-Diab, Randall C. Johnson, Douglas S. Kwon, Marylyn M. Addo, Chanson Brumme, Jean-Pierre Routy, Susan Little, Heiko K. Jessen, Anthony D. Kelleher, Frederick M. Hecht, Rafick-Pierre Sekaly, Eric S. Rosenberg, Bruce D. Walker, Mary Carrington, and Marcus Altfeld. Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells. J. Virol., 83(15):7641-7648, Aug 2009. PubMed ID: 19458000. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 014A-006: A*01:01, B*08:01, B*14:01, C*07:02, C*08:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | acute/early infection |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(83-91) DNA(9043..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
AAVDLSHFL
|
Epitope Alignment
|
Epitope Name | Cw8-AL9 | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | immunodominance, acute/early infection, chronic infection |
Streeck2009a Hendrik Streeck, Jonathan S. Jolin, Ying Qi, Bader Yassine-Diab, Randall C. Johnson, Douglas S. Kwon, Marylyn M. Addo, Chanson Brumme, Jean-Pierre Routy, Susan Little, Heiko K. Jessen, Anthony D. Kelleher, Frederick M. Hecht, Rafick-Pierre Sekaly, Eric S. Rosenberg, Bruce D. Walker, Mary Carrington, and Marcus Altfeld. Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells. J. Virol., 83(15):7641-7648, Aug 2009. PubMed ID: 19458000. Show all entries for this paper.
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