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Displaying record number 839

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MAb ID 1583
HXB2 Location Env(728-745)
DNA(8406..8459)
Env Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing no
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 5 of 5 notes.

References

Showing 5 of 5 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.

Sattentau1995 Q. J. Sattentau, S. Zolla-Pazner, and P. Poignard. Epitope Exposure on Functional, Oligomeric HIV-1 gp41 Molecules. Virology, 206:713-717, 1995. Most gp41 epitopes are masked when associated with gp120 on the cell surface. Weak binding of anti-gp41 MAbs can be enhanced by treatment with sCD4. MAb 2F5 binds to a membrane proximal epitope which binds in the presence of gp120 without sCD4. PubMed ID: 7530400. Show all entries for this paper.

Dimmock2005 Nigel J. Dimmock. The Complex Antigenicity of a Small External Region of the C-Terminal Tail of the HIV-1 gp41 Envelope Protein: A Lesson in Epitope Analysis. Rev. Med. Virol., 15(6):365-381, Nov-Dec 2005. PubMed ID: 16106492. Show all entries for this paper.

Heap2005a Caroline J. Heap, Steven A. Reading, and Nigel J. Dimmock. An Antibody Specific for the C-Terminal Tail of the gp41 Transmembrane Protein of Human Immunodeficiency Virus Type 1 Mediates Post-Attachment Neutralization, Probably Through Inhibition of Virus-Cell Fusion. J. Gen. Virol., 86(5):1499-1507, May 2005. PubMed ID: 15831963. Show all entries for this paper.


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