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MAb ID | B9 | |
---|---|---|
HXB2 Location | Env(93-96) DNA(6501..6512) |
Env Epitope Map |
Author Location | gp120(93-96 LAI) | |
Epitope |
FNMW
|
Epitope Alignment
|
Subtype | B | |
Ab Type | gp120 C1 | |
Neutralizing | P (tier 2) | |
Species (Isotype) | mouse(IgG1) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | gp160 |
Showing 2 of 2 notes.
Showing 1 of 1 references.
Abacioglu1994 Y. H. Abacioglu, T. R. Fouts, J. D. Laman, E. Claassen, S. H. Pincus, J. P. Moore, C. A. Roby, R. Kamin-Lewis, and G. K. Lewis. Epitope Mapping and Topology of Baculovirus-Expressed HIV-1 gp160 Determined with a Panel of Murine Monoclonal Antibodies. AIDS Res. Hum. Retroviruses, 10:371-381, 1994. Thirty MAbs were obtained from BALB/c mice immunized with rgp160 LAI expressed in baculovirus. These antibodies map to 4 domains: gp120 C1, C2, C3/V4, and the cytoplasmic tail of gp41. All epitopes were exposed on rgp160 without denaturing the protein, but 6/8 epitopes mapped in gp120 are not exposed unless the protein is denatured, showing rgp160 and rgp120 fold differently. PubMed ID: 8068416. Show all entries for this paper.
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