Found 9 matching records:
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MAb ID | Fab S9 (S9) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41( LAI) | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp41 cluster II | |
Neutralizing | ||
Species (Isotype) | human(IgG1κ) | |
Patient | S | |
Immunogen | HIV-1 infection | |
Keywords | antibody binding site, antibody generation, antibody interactions, antibody sequence, review |
Showing 2 of 2 notes.
Showing 2 of 2 references.
Isolation Paper
Binley1996
J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976.
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Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.
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MAb ID | VRC26.25 E100bV/K100sR/L:S95bD | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
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|
Subtype | C | |
Ab Type | gp120 V2 // V2 glycan(V2g) // V2 apex | |
Neutralizing | P (tier 2) View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | CAP256 | |
Immunogen | HIV-1 infection | |
Keywords | antibody generation, neutralization |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Yin2021
Yiming Yin, Brian D. Quinlan, Tianling Ou, Yan Guo, Wenhui He, and Michael Farzan. In Vitro Affinity Maturation of Broader and More-Potent Variants of the HIV-1-Neutralizing Antibody CAP256-VRC26.25. Proc. Natl. Acad. Sci. U.S.A., 118(29):e2106203118, 20 Jul 2021. PubMed ID: 34261793.
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MAb ID | ITS99 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp120 | |
Epitope |
|
|
Ab Type | gp120 CD4bs | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | 8E-9 | |
Immunogen | SIV infection | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
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MAb ID | ITS92.01 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | ITS92.02 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | ITS92.03 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | ITS92.04 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | ITS92.05 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | ITS92.06 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41 | |
Epitope |
|
|
Ab Type | gp41 | |
Neutralizing | ||
Species (Isotype) | macaque | |
Patient | IK16 | |
Immunogen | SIV infection, vaccine | |
Keywords | antibody binding site, antibody lineage, antibody sequence, neutralization, SIV |
Vaccine strain | SIV |
---|
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Welles2022
Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309.
Show all entries for this paper.
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