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HIV Molecular Immunology Database

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Found 9 matching records:

Displaying record number 881

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MAb ID Fab S9 (S9)
HXB2 Location Env Env Epitope Map
Author Location gp41( LAI)
Epitope
Subtype B
Ab Type gp41 cluster II
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient S
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody interactions, antibody sequence, review

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.


Displaying record number 4327

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MAb ID VRC26.25 E100bV/K100sR/L:S95bD
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype C
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CAP256
Immunogen HIV-1 infection
Keywords antibody generation, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Yin2021 Yiming Yin, Brian D. Quinlan, Tianling Ou, Yan Guo, Wenhui He, and Michael Farzan. In Vitro Affinity Maturation of Broader and More-Potent Variants of the HIV-1-Neutralizing Antibody CAP256-VRC26.25. Proc. Natl. Acad. Sci. U.S.A., 118(29):e2106203118, 20 Jul 2021. PubMed ID: 34261793. Show all entries for this paper.


Displaying record number 4661

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MAb ID ITS99
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Ab Type gp120 CD4bs
Neutralizing  
Species (Isotype) macaque
Patient 8E-9
Immunogen SIV infection
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4673

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MAb ID ITS92.01
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4674

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MAb ID ITS92.02
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4675

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MAb ID ITS92.03
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4676

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MAb ID ITS92.04
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4677

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MAb ID ITS92.05
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


Displaying record number 4678

Download this epitope record as JSON.

MAb ID ITS92.06
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41
Neutralizing  
Species (Isotype) macaque
Patient IK16
Immunogen SIV infection, vaccine
Keywords antibody binding site, antibody lineage, antibody sequence, neutralization, SIV

Vaccine Details

Vaccine strain SIV

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Welles2022 Hugh C. Welles, Hannah A. D. King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A. Schramm, Nicole A. Doria-Rose, Adrienne E. Swanstrom, James A. Hoxie, Celia LaBranche, David C. Montefiori, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Mario Roederer, and Rosemarie D. Mason. Broad Coverage of Neutralization-Resistant SIV Strains by Second-Generation SIV-Specific Antibodies Targeting the Region Involved in Binding CD4. PLoS Pathog., 18(6):e1010574, Jun 2022. PubMed ID: 35709309. Show all entries for this paper.


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