Found 40 matching records:
Download this epitope record as JSON.
MAb ID | 9G5 | |
---|---|---|
HXB2 Location | Gag(119-132) DNA(1144..1185) |
Gag Epitope Map |
Author Location | p17(121-134 SF2) | |
Research Contact | R. B. Ferns and R. S. Tedder | |
Epitope |
AAGTGNSSQVSQNY
|
Epitope Alignment
|
Ab Type | ||
Neutralizing | ||
Species (Isotype) | mouse(IgM) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | inactivated HIV |
---|---|
Vaccine strain | B clade CBL-1 |
Vaccine component | HIV-1 |
Showing 2 of 2 notes.
Showing 2 of 2 references.
Ferns1987 R. B. Ferns, R. S. Tedder, and R. A. Weiss. Characterization of Monoclonal Antibodies against the Human Immunodeficiency Virus gag Products and Their Use in Monitoring HIV Isolate Variation. J. Gen. Virol., 68:1543-1551, 1987. PubMed ID: 2438375. Show all entries for this paper.
Ferns1989 R. B. Ferns, J. C. Partridge, R. P. Spence, N. Hunt, and R. S. Tedder. Epitope Location of 13 Anti-Gag HIV-1 Monoclonal Antibodies Using Oligopeptides and their Cross-Reactivity with HIV-2. AIDS, 3:829-834, 1989. PubMed ID: 2483619. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 1G5C8 | |
---|---|---|
HXB2 Location | Gag(201-218) DNA(1390..1443) |
Gag Epitope Map |
Author Location | p24(201-218 BRU) | |
Epitope |
LKETINEEAAEWDRVHPV
|
Epitope Alignment
|
Ab Type | ||
Neutralizing | ||
Species (Isotype) | mouse(IgG2b) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine component | p24 Gag |
Showing 1 of 1 note.
Showing 4 of 4 reference.
Janvier1990 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2. J. Virol., 64:4258-4263, 1990. PubMed ID: 1696638. Show all entries for this paper.
Janvier1992 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2 (Author's Correction). J. Virol., 66:613, 1992. Show all entries for this paper.
RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.
RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.
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MAb ID | 23A5G5 | |
---|---|---|
HXB2 Location | Gag(285-304) DNA(1642..1701) |
Gag Epitope Map |
Author Location | p24(285-304 BRU) | |
Epitope |
IRQGPKEPFRDYVDRFYKTL
|
Epitope Alignment
|
Ab Type | ||
Neutralizing | ||
Species (Isotype) | mouse(IgG) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | p24 Gag |
Showing 2 of 2 references.
RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.
RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 8G5 | |
---|---|---|
HXB2 Location | Pol(94-101) DNA(2364..2387) |
Pol Epitope Map |
Author Location | Protease(38-45 HXB2) | |
Epitope |
LPGRWKPK
|
Epitope Alignment
|
Subtype | B | |
Ab Type | ||
Neutralizing | ||
Species (Isotype) | hamster(IgG) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine component | Protease |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Croix1993 D. A. Croix, H. Y. Yeh, J. Sedlacek, R. B. Luftig, and P. D. Gottlieb. A Dominant Epitope of HIV-1 Protease Recognized by Hamster Monoclonal Antibodies. J. Acquir. Immune Defic. Syndr., 6:558-566, 1993. PubMed ID: 8496788. Show all entries for this paper.
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MAb ID | 6G5 | |
---|---|---|
HXB2 Location | Pol(716-731) DNA(4230..4277) |
Pol Epitope Map |
Author Location | Integrase(1-16 HXB2) | |
Epitope |
FLDGIDKAQDEHEKYH
|
Epitope Alignment
|
Subtype | B | |
Ab Type | N-term | |
Neutralizing | ||
Species (Isotype) | mouse(IgG1κ) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade HXB2 |
Vaccine component | Int |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.
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MAb ID | D/3G5 | |
---|---|---|
HXB2 Location | Env(73-82) DNA(6441..6470) |
Env Epitope Map |
Author Location | gp120(73-82 LAI) | |
Epitope |
ACVPTDPNPQ
|
Epitope Alignment
|
Subtype | B | |
Ab Type | gp120 C1 | |
Neutralizing | ||
Species (Isotype) | mouse(IgG1) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | gp120 |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Bristow1994 R. G. W. Bristow, A. R. Douglas, J. J. Skehel, and R. S Daniels. Analysis of murine antibody responses to baculovirus-expressed human immunodeficiency virus type 1 envelope glycoproteins. J. Gen. Virol., 75:2089-2095, 1994. BALB/c mice were immunized with baculovirus expressed gp160 or gp120, and 15 MAbs were generated. No MAbs generated in this study neutralized reference strains, using a tetrazolium-based cytotoxicity assay to test for neutralization. Ten of the Mabs were mapped by peptide ELISA, and seven reacted with the C1 region, one with V2, one with V4, and one with the C-terminal end. PubMed ID: 7519249. Show all entries for this paper.
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MAb ID | BG505.57 | |
---|---|---|
HXB2 Location | Env(304-313) DNA(7134..7163) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGP
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.56 | |
---|---|---|
HXB2 Location | Env(304-313) DNA(7134..7163) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGP
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.63 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.49 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.69 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.48 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.68 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.50 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.61 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.13 | |
---|---|---|
HXB2 Location | Env(304-322) DNA(7134..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
RKSIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.34 | |
---|---|---|
HXB2 Location | Env(306-322) DNA(7140..7190) |
Env Epitope Map |
Author Location | ||
Epitope |
SIRIGPGQAFYATGD
|
Epitope Alignment
|
Subtype | A1 | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 9G5A | |
---|---|---|
HXB2 Location | Env(591-594) DNA(7995..8006) |
Env Epitope Map |
Author Location | gp41(596-599 IIIB) | |
Epitope |
QLLG
|
Epitope Alignment
|
Ab Type | ||
Neutralizing | ||
Species (Isotype) | mouse(IgM) | |
Patient | ||
Immunogen | anti-idiotype | |
Keywords |
Showing 1 of 1 note.
Showing 2 of 2 reference.
Beretta1994 A. Beretta and A.G. Dalgleish. B-Cell Epitopes. AIDS, 8(suppl 1):S133-S145, 1994. Show all entries for this paper.
Lopalco1993 L. Lopalco, R. Longhi, F. Ciccomascolo, A. De Rossi, M. Pelagi, F. Andronico, J. P. Moore, B T. Schulz, A. Beretta, and A. G. Siccardi. Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies. AIDS Res. Hum. Retroviruses, 9:33-39, 1993. The MAb M38 binds to the carboxy terminus of gp120, in a gp41 binding region. This MAb was used to create an anti-idiotype MAb, 9G5A, which can bind to gp41 at the base of the cysteine loop. The binding domains of these two monoclonals are consistent with the C5 domain of gp120 being able to bind to the gp41 cysteine loop. The MAb M38 also binds to human HLA molecules, in antigenic homology or possibly molecular mimicry. PubMed ID: 7678970. Show all entries for this paper.
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MAb ID | BG505.23 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | gp120 | |
Neutralizing | View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.25 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | gp120 | |
Neutralizing | View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.36 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | gp120 | |
Neutralizing | View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG505.42 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | ||
Neutralizing | View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
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Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
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Download this epitope record as JSON.
MAb ID | BG505.46 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | ||
Neutralizing | View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Simonich2021
Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | Fab G5 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp41( LAI) | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp41 cluster III | |
Neutralizing | ||
Species (Isotype) | human(IgG1κ) | |
Patient | G | |
Immunogen | HIV-1 infection | |
Keywords | antibody binding site, antibody generation, antibody sequence, review |
Showing 2 of 2 notes.
Showing 2 of 2 references.
Isolation Paper
Binley1996
J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976.
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Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 52G5/B9 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp120(gp120 SF162) | |
Research Contact | Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org | |
Epitope |
|
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Subtype | B | |
Ab Type | ||
Neutralizing | no | |
Species (Isotype) | transgenic mouse(IgG2κ) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade SF162 |
Vaccine component | gp120 |
Adjuvant | Ribi adjuvant (MPL+TDM) (RIBI) |
Showing 1 of 1 note.
Showing 1 of 1 reference.
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 4KG5 (4KG.5) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp120( JR-FL) | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 V1-V2-V3 | |
Neutralizing | ||
Species (Isotype) | human(IgG) | |
Patient | FDA2 | |
Immunogen | HIV-1 infection | |
Keywords | antibody binding site, antibody generation, antibody interactions, antibody sequence, assay or method development, binding affinity, neutralization, structure, subtype comparisons, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity |
Showing 4 of 4 notes.
Showing 4 of 4 references.
Isolation Paper
Zwick2003a
Michael B. Zwick, Robert Kelleher, Richard Jensen, Aran F. Labrijn, Meng Wang, Gerald V. Quinnan, Jr., Paul W. H. I. Parren, and Dennis R. Burton. A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12. J. Virol., 77(12):6965-6978, Jun 2003. PubMed ID: 12768015.
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Selvarajah2005 Suganya Selvarajah, Bridget Puffer, Ralph Pantophlet, Mansun Law, Robert W. Doms, and Dennis R. Burton. Comparing Antigenicity and Immunogenicity of Engineered gp120. J. Virol., 79(19):12148-12163, Oct 2005. PubMed ID: 16160142. Show all entries for this paper.
Bowley2007 D. R. Bowley, A. F. Labrijn, M. B. Zwick, and D. R. Burton. Antigen Selection from an HIV-1 Immune Antibody Library Displayed on Yeast Yields Many Novel Antibodies Compared to Selection from the Same Library Displayed on Phage. Protein Eng. Des. Sel., 20(2):81-90, Feb 2007. PubMed ID: 17242026. Show all entries for this paper.
Cham2006 Fatim Cham, Peng Fei Zhang, Leo Heyndrickx, Peter Bouma, Ping Zhong, Herman Katinger, James Robinson, Guido van der Groen, and Gerald V. Quinnan, Jr. Neutralization and Infectivity Characteristics of Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Infected Donors Whose Sera Exhibit Broadly Cross-Reactive Neutralizing Activity. Virology, 347(1):36-51, 30 Mar 2006. PubMed ID: 16378633. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 11G5 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | gp160 (V3)(303-338) | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | ||
Species (Isotype) | human | |
Patient | ||
Immunogen | ||
Keywords |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Callahan1991 Lawrence N. Callahan, Michael Phelan, Margherita Mallinson, and Michael A. Norcross. Dextran Sulfate Blocks Antibody Binding to the Principal Neutralizing Domain of Human Immunodeficiency Virus Type 1 without Interfering with gp120-CD4 Interactions. J. Virol., 65(3):1543-1550, Mar 1991. PubMed ID: 1995952. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 114-4G5 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | Env | |
Research Contact | Julia L. Hurwitz, St. Jude Children's research Hospital, julia.hurwitz@stjude.org | |
Epitope |
|
|
Ab Type | ||
Neutralizing | ||
Species (Isotype) | ||
Patient | ||
Immunogen | ||
Keywords | variant cross-reactivity |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Slobod2005 Karen S. Slobod, Chris Coleclough, Mattia Bonsignori, Scott A. Brown, Xiaoyan Zhan, Sherri Surman, Amy Zirkel, Bart G. Jones, Robert E. Sealy, John Stambas, Brita Brown, Timothy D. Lockey, Pamela J. Freiden, Peter C. Doherty, James L. Blanchard, Louis N. Martin, and Julia L. Hurwitz. HIV Vaccine Rationale, Design and Testing. Curr. HIV Res., 3(2):107-112, Apr 2005. PubMed ID: 15853717. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 2B10G5 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | Env | |
Epitope |
|
|
Subtype | B | |
Ab Type | ||
Neutralizing | ||
Species (Isotype) | llama | |
Patient | ||
Immunogen | in vitro stimulation or selection | |
Keywords | binding affinity, kinetics, neutralization, variant cross-reactivity |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Koh2010 Willie W. L. Koh, Soren Steffensen, Maria Gonzalez-Pajuelo, Bart Hoorelbeke, Andrea Gorlani, Agnieszka Szynol, Anna Forsman, Marlén M. I. Aasa-Chapman, Hans de Haard, Theo Verrips, and Robin A. Weiss. Generation of a Family-Specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1. J. Biol. Chem., 285(25):19116-19124, 18 Jun 2010. PubMed ID: 20400507. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | NIH45-46G54W (NIH45-46 G54W, 45-46W,NIH45-46W) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | acute/early infection, anti-idiotype, antibody binding site, antibody generation, antibody interactions, antibody polyreactivity, assay or method development, autologous responses, binding affinity, broad neutralizer, computational prediction, effector function, elite controllers and/or long-term non-progressors, escape, glycosylation, immunotherapy, neutralization, polyclonal antibodies, rate of progression, review, SIV, structure, subtype comparisons, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity |
Showing 26 of 26 notes.
Showing 26 of 26 references.
Isolation Paper
Diskin2011
Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520.
Show all entries for this paper.
Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.
Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.
Carbonetti2014 Sara Carbonetti, Brian G. Oliver, Jolene Glenn, Leonidas Stamatatos, and D. Noah Sather. Soluble HIV-1 Envelope Immunogens Derived from an Elite Neutralizer Elicit Cross-Reactive V1V2 Antibodies and Low Potency Neutralizing Antibodies. PLoS One, 9(1):e86905, 2014. PubMed ID: 24466285. Show all entries for this paper.
Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.
Gardner2016 Matthew R. Gardner, Christoph H. Fellinger, Neha R. Prasad, Amber S. Zhou, Hema R. Kondur, Vinita R. Joshi, Brian D. Quinlan, and Michael Farzan. CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies. J. Virol., 90(17):7822-7832, 1 Sep 2016. PubMed ID: 27334589. Show all entries for this paper.
Goo2012 Leslie Goo, Zahra Jalalian-Lechak, Barbra A. Richardson, and Julie Overbaugh. A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection. J. Virol., 86(19):10857-10861, Oct 2012. PubMed ID: 22837204. Show all entries for this paper.
Halper-Stromberg2016 Ariel Halper-Stromberg and Michel C Nussenzweig. Towards HIV-1 Remission: Potential Roles for Broadly Neutralizing Antibodies. J. Clin. Invest., 126(2):415-423, Feb 2016. PubMed ID: 26752643. Show all entries for this paper.
Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.
Julien2015 Jean-Philippe Julien, Jeong Hyun Lee, Gabriel Ozorowski, Yuanzi Hua, Alba Torrents de la Peña, Steven W. de Taeye, Travis Nieusma, Albert Cupo, Anila Yasmeen, Michael Golabek, Pavel Pugach, P. J. Klasse, John P. Moore, Rogier W. Sanders, Andrew B. Ward, and Ian A. Wilson. Design and Structure of Two HIV-1 Clade C SOSIP.664 Trimers That Increase the Arsenal of Native-Like Env Immunogens. Proc. Natl. Acad. Sci. U.S.A., 112(38):11947-11952, 22 Sep 2015. PubMed ID: 26372963. Show all entries for this paper.
Klein2012a Florian Klein, Ariel Halper-Stromberg, Joshua A. Horwitz, Henning Gruell, Johannes F. Scheid, Stylianos Bournazos, Hugo Mouquet, Linda A. Spatz, Ron Diskin, Alexander Abadir, Trinity Zang, Marcus Dorner, Eva Billerbeck, Rachael N. Labitt, Christian Gaebler, Paola M. Marcovecchio, Reha-Baris Incesu, Thomas R. Eisenreich, Paul D. Bieniasz, Michael S. Seaman, Pamela J. Bjorkman, Jeffrey V. Ravetch, Alexander Ploss, and Michel C. Nussenzweig. HIV Therapy by a Combination of Broadly Neutralizing Antibodies in Humanized Mice. Nature, 492(7427):118-122, 6 Dec 2012. PubMed ID: 23103874. Show all entries for this paper.
Mishra2020 Nitesh Mishra, Shaifali Sharma, Ayushman Dobhal, Sanjeev Kumar, Himanshi Chawla, Ravinder Singh, Bimal Kumar Das, Sushil Kumar Kabra, Rakesh Lodha, and Kalpana Luthra. A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex. J. Virol., 94(19), 15 Sep 2020. PubMed ID: 32669335. Show all entries for this paper.
Mishra2021 Nitesh Mishra, Sanjeev Kumar, Swarandeep Singh, Tanu Bansal, Nishkarsh Jain, Sumedha Saluja, Rajesh Kumar, Sankar Bhattacharyya, Jayanth Kumar Palanichamy, Riyaz Ahmad Mir, Subrata Sinha, and Kalpana Luthra. Cross-Neutralization of SARS-CoV-2 by HIV-1 Specific Broadly Neutralizing Antibodies and Polyclonal Plasma. PLoS Pathog., 17(9):e1009958, Sep 2021. PubMed ID: 34559854. Show all entries for this paper.
Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.
Mouquet2012a Hugo Mouquet, Louise Scharf, Zelda Euler, Yan Liu, Caroline Eden, Johannes F. Scheid, Ariel Halper-Stromberg, Priyanthi N. P. Gnanapragasam, Daniel I. R. Spencer, Michael S. Seaman, Hanneke Schuitemaker, Ten Feizi, Michel C. Nussenzweig, and Pamela J. Bjorkman. Complex-Type N-Glycan Recognition by Potent Broadly Neutralizing HIV Antibodies. Proc. Natl. Acad. Sci. U.S.A, 109(47):E3268-E3277, 20 Nov 2012. PubMed ID: 23115339. Show all entries for this paper.
Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.
Rosenberg2015 Yvonne Rosenberg, Markus Sack, David Montefiori, Celia Labranche, Mark Lewis, Lori Urban, Lingjun Mao, Rainer Fischer, and Xiaoming Jiang. Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques. PLoS One, 10(3):e0120451, 25 Mar 2015. PubMed ID: 25807114. Show all entries for this paper.
Sanders2013 Rogier W. Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J. Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de los Reyes, Thomas J. Ketas, Marit J. van Gils, C. Richter King, Ian A. Wilson, Andrew B. Ward, P. J. Klasse, and John P. Moore. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but not Non-Neutralizing Antibodies. PLoS Pathog., 9(9):e1003618, Sep 2013. PubMed ID: 24068931. Show all entries for this paper.
Sather2012 D. Noah Sather, Sara Carbonetti, Jenny Kehayia, Zane Kraft, Iliyana Mikell, Johannes F. Scheid, Florian Klein, and Leonidas Stamatatos. Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus. J. Virol., 86(23):12676-12685, Dec 2012. PubMed ID: 22973035. Show all entries for this paper.
Stefic2019 Karl Stefic, Mélanie Bouvin-Pley, Asma Essat, Clara Visdeloup, Alain Moreau, Cécile Goujard, Marie-Laure Chaix, Martine Braibant, Laurence Meyer, and Francis Barin. Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02\_AG Viruses with a Focus on Evolution over Time. J. Virol., 93(2), 15 Jan 2019. PubMed ID: 30404804. Show all entries for this paper.
Wang2018a Hongye Wang, Ting Yuan, Tingting Li, Yanpeng Li, Feng Qian, Chuanwu Zhu, Shujia Liang, Daniel Hoffmann, Ulf Dittmer, Binlian Sun, and Rongge Yang. Evaluation of Susceptibility of HIV-1 CRF01\_AE Variants to Neutralization by a Panel of Broadly Neutralizing Antibodies. Arch. Virol., 163(12):3303-3315, Dec 2018. PubMed ID: 30196320. Show all entries for this paper.
West2013 Anthony P. West, Jr., Louise Scharf, Joshua Horwitz, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. Computational Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify Potential Functional Epitope Residues. Proc. Natl. Acad. Sci. U.S.A., 110(26):10598-10603, 25 Jun 2013. PubMed ID: 23754383. Show all entries for this paper.
Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.
Beretta2018 Maxime Beretta, Alain Moreau, Mélanie Bouvin-Pley, Asma Essat, Cécile Goujard, Marie-Laure Chaix, Stéphane Hue, Laurence Meyer, Francis Barin, Martine Braibant, and ANRS 06 Primo Cohort. Phenotypic Properties of Envelope Glycoproteins of Transmitted HIV-1 Variants from Patients Belonging to Transmission Chains. AIDS, 32(14):1917-1926, 10 Sep 2018. PubMed ID: 29927786. Show all entries for this paper.
Berendam2021 Stella J. Berendam, Tiffany M. Styles, Papa K.. Morgan-Asiedu, DeAnna Tenney, Amit Kumar, Veronica Obregon-Perko, Katharine J. Bar, Kevin O. Saunders, Sampa Santra, Kristina De Paris, Georgia D. Tomaras, Ann Chahroudi, Sallie R. Permar, Rama R. Amara, and Genevieve G. Fouda. Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses. J. Virol., 95(3), 13 Jan 2021. PubMed ID: 33177194. Show all entries for this paper.
Moyo2018 Thandeka Moyo, June Ereño-Orbea, Rajesh Abraham Jacob, Clara E. Pavillet, Samuel Mundia Kariuki, Emily N. Tangie, Jean-Philippe Julien, and Jeffrey R. Dorfman. Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11. J. Virol., 92(14), 15 Jul 2018. PubMed ID: 29618644. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 45-46m2 (NIH45-46G54W.HC, S28Y.LC, m2) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, antibody polyreactivity, binding affinity, immunotherapy, neutralization, review, SIV, structure, subtype comparisons |
Showing 6 of 6 notes.
Showing 6 of 6 references.
Isolation Paper
Diskin2013
Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429.
Show all entries for this paper.
Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.
Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.
Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.
Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.
Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 45-46m7 (NIH45-46G54W,W47V.HC,S28Y.LC, m7) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Contacts and Features | View contacts and features | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, antibody polyreactivity, binding affinity, immunotherapy, neutralization, review, SIV, structure, subtype comparisons |
Showing 6 of 6 notes.
Showing 6 of 6 references.
Isolation Paper
Diskin2013
Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429.
Show all entries for this paper.
Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.
Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.
Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.
Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.
Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | NIH45-46G54F (45-46F) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, binding affinity, neutralization |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Diskin2011
Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | NIH45-46G54Y (45-46Y) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, binding affinity, neutralization |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Diskin2011
Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 45-46m25 (NIH45-46G54W,W47I.HC,S28Y.LC, m25) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, immunotherapy, neutralization, review, structure, subtype comparisons |
Showing 3 of 3 notes.
Showing 3 of 3 references.
Isolation Paper
Diskin2013
Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429.
Show all entries for this paper.
Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.
Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | 45-46m28 (NIH45-46G54W,W47T.HC,S28Y.LC, NIH45-46m28, m28) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, immunotherapy, neutralization, review, structure, subtype comparisons |
Showing 3 of 3 notes.
Showing 3 of 3 references.
Isolation Paper
Diskin2013
Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429.
Show all entries for this paper.
Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.
Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | VRC07G54W (VRC07-G54W) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | yes | |
Species (Isotype) | human(IgG) | |
Patient | NIH45 | |
Immunogen | ||
Keywords | antibody generation, antibody polyreactivity, autoantibody or autoimmunity, review, structure |
Showing 6 of 6 notes.
Showing 7 of 7 references.
Balazs2013 Alejandro B. Balazs and Anthony P. West, Jr. Antibody Gene Transfer for HIV Immunoprophylaxis. Nat. Immunol., 14(1):1-5, Jan 2013. PubMed ID: 23238748. Show all entries for this paper.
Krebs2019 Shelly J. Krebs, Young D. Kwon, Chaim A. Schramm, William H. Law, Gina Donofrio, Kenneth H. Zhou, Syna Gift, Vincent Dussupt, Ivelin S. Georgiev, Sebastian Schätzle, Jonathan R. McDaniel, Yen-Ting Lai, Mallika Sastry, Baoshan Zhang, Marissa C. Jarosinski, Amy Ransier, Agnes L. Chenine, Mangaiarkarasi Asokan, Robert T. Bailer, Meera Bose, Alberto Cagigi, Evan M. Cale, Gwo-Yu Chuang, Samuel Darko, Jefferson I. Driscoll, Aliaksandr Druz, Jason Gorman, Farida Laboune, Mark K. Louder, Krisha McKee, Letzibeth Mendez, M. Anthony Moody, Anne Marie O'Sullivan, Christopher Owen, Dongjun Peng, Reda Rawi, Eric Sanders-Buell, Chen-Hsiang Shen, Andrea R. Shiakolas, Tyler Stephens, Yaroslav Tsybovsky, Courtney Tucker, Raffaello Verardi, Keyun Wang, Jing Zhou, Tongqing Zhou, George Georgiou, S Munir Alam, Barton F. Haynes, Morgane Rolland, Gary R. Matyas, Victoria R. Polonis, Adrian B. McDermott, Daniel C. Douek, Lawrence Shapiro, Sodsai Tovanabutra, Nelson L. Michael, John R. Mascola, Merlin L. Robb, Peter D. Kwong, and Nicole A. Doria-Rose. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50(3):677-691.e13, 19 Mar 2019. PubMed ID: 30876875. Show all entries for this paper.
Kwon2012a Y. Kwon, I. Georgiev, S. O'Dell, W. Shi, G. Chuang, Y. Yang, Zhang, J. Zhu, G. J. Nabel, J. R. Mascola, and P. D. Kwong. Structure-Guided Modification and Optimization of Antibody VRC07. Retrovirology, 9(s2):O34, 2012. Show all entries for this paper.
Liu2019 Qingbo Liu, Yen-Ting Lai, Peng Zhang, Mark K. Louder, Amarendra Pegu, Reda Rawi, Mangaiarkarasi Asokan, Xuejun Chen, Chen-Hsiang Shen, Gwo-Yu Chuang, Eun Sung Yang, Huiyi Miao, Yuge Wang, Anthony S. Fauci, Peter D. Kwong, John R. Mascola, and Paolo Lusso. Improvement of Antibody Functionality by Structure-Guided Paratope Engraftment. Nat. Commun., 10(1):721, 13 Feb 2019. PubMed ID: 30760721. Show all entries for this paper.
Rudicell2014 Rebecca S. Rudicell, Young Do Kwon, Sung-Youl Ko, Amarendra Pegu, Mark K. Louder, Ivelin S. Georgiev, Xueling Wu, Jiang Zhu, Jeffrey C. Boyington, Xuejun Chen, Wei Shi, Zhi-Yong Yang, Nicole A. Doria-Rose, Krisha McKee, Sijy O'Dell, Stephen D. Schmidt, Gwo-Yu Chuang, Aliaksandr Druz, Cinque Soto, Yongping Yang, Baoshan Zhang, Tongqing Zhou, John-Paul Todd, Krissey E. Lloyd, Joshua Eudailey, Kyle E. Roberts, Bruce R. Donald, Robert T. Bailer, Julie Ledgerwood, NISC Comparative Sequencing Program, James C. Mullikin, Lawrence Shapiro, Richard A. Koup, Barney S. Graham, Martha C. Nason, Mark Connors, Barton F. Haynes, Srinivas S. Rao, Mario Roederer, Peter D. Kwong, John R. Mascola, and Gary J. Nabel. Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J. Virol., 88(21):12669-12682, 1 Nov 2014. PubMed ID: 25142607. Show all entries for this paper.
Yang2014 Lili Yang and Pin Wang. Passive Immunization against HIV/AIDS by Antibody Gene Transfer. Viruses, 6(2):428-447, Feb 2014. PubMed ID: 24473340. Show all entries for this paper.
Kwon2023 Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, and Peter D. Kwong. Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain. MAbs, 15(1):2223350 doi, Jan-Dec 2023. PubMed ID: 37345226 Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG5 | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | Env | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P (tier 2) View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | 391370 | |
Immunogen | HIV-1 infection | |
Country | United States | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, autoantibody or autoimmunity, broad neutralizer, contact residues, germline, immunotherapy, neutralization, polyclonal antibodies |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Barnes2022
Christopher O. Barnes, Till Schoofs, Priyanthi N. P. Gnanapragasam, Jovana Golijanin, Kathryn E. Huey-Tubman, Henning Gruell, Philipp Schommers, Nina Suh-Toma, Yu Erica Lee, Julio C. Cetrulo Lorenzi, Alicja Piechocka-Trocha, Johannes F. Scheid, Anthony P. West, Jr., Bruce D. Walker, Michael S. Seaman, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. A Naturally Arising Broad and Potent CD4-Binding Site Antibody with Low Somatic Mutation. Sci. Adv., 8(32):eabp8155, 12 Aug 2022. PubMed ID: 35960796.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | BG24-G54W | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | Env | |
Epitope |
|
|
Subtype | B | |
Ab Type | gp120 CD4bs | |
Neutralizing | P (tier 2) View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | 391370 | |
Immunogen | HIV-1 infection | |
Country | United States | |
Keywords | antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, autoantibody or autoimmunity, broad neutralizer, contact residues, germline, immunotherapy, neutralization, polyclonal antibodies |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Isolation Paper
Barnes2022
Christopher O. Barnes, Till Schoofs, Priyanthi N. P. Gnanapragasam, Jovana Golijanin, Kathryn E. Huey-Tubman, Henning Gruell, Philipp Schommers, Nina Suh-Toma, Yu Erica Lee, Julio C. Cetrulo Lorenzi, Alicja Piechocka-Trocha, Johannes F. Scheid, Anthony P. West, Jr., Bruce D. Walker, Michael S. Seaman, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. A Naturally Arising Broad and Potent CD4-Binding Site Antibody with Low Somatic Mutation. Sci. Adv., 8(32):eabp8155, 12 Aug 2022. PubMed ID: 35960796.
Show all entries for this paper.
Download this epitope record as JSON.
MAb ID | polyclonal BG505 M27 (polyclonal BG505 25.3 mo pi) | |
---|---|---|
HXB2 Location | Env | Env Epitope Map |
Author Location | ||
Epitope |
|
|
Subtype | A1 | |
Ab Type | gp41 MPER (membrane proximal external region) | |
Neutralizing | P (tier 2) View neutralization details | |
Species (Isotype) | human | |
Patient | BG505 | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Keywords | antibody binding site, antibody generation, antibody lineage, autologous responses, broad neutralizer, neutralization, polyclonal antibodies, responses in children |
Showing 3 of 3 notes.
Showing 3 of 3 references.
Isolation Paper
Wu2006a
Xueling Wu, Adam B. Parast, Barbra A. Richardson, Ruth Nduati, Grace John-Stewart, Dorothy Mbori-Ngacha, Stephanie M. J. Rainwater, and Julie Overbaugh. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol, 80(2):835-44 doi, Jan 2006. PubMed ID: 16378985
Show all entries for this paper.
Goo2014 Leslie Goo, Vrasha Chohan, Ruth Nduati, and Julie Overbaugh. Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat Med, 20(6):655-8 doi, Jun 2014. PubMed ID: 24859529 Show all entries for this paper.
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.
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