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HIV Molecular Immunology Database

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Found 40 matching records:

Displaying record number 33

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MAb ID 9G5
HXB2 Location Gag(119-132)
DNA(1144..1185)
Gag Epitope Map
Author Location p17(121-134 SF2)
Research Contact R. B. Ferns and R. S. Tedder
Epitope AAGTGNSSQVSQNY Epitope Alignment
AAGTGNSSQVSQNY epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgM)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type inactivated HIV
Vaccine strain B clade CBL-1
Vaccine component HIV-1

Notes

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References

Showing 2 of 2 references.

Ferns1987 R. B. Ferns, R. S. Tedder, and R. A. Weiss. Characterization of Monoclonal Antibodies against the Human Immunodeficiency Virus gag Products and Their Use in Monitoring HIV Isolate Variation. J. Gen. Virol., 68:1543-1551, 1987. PubMed ID: 2438375. Show all entries for this paper.

Ferns1989 R. B. Ferns, J. C. Partridge, R. P. Spence, N. Hunt, and R. S. Tedder. Epitope Location of 13 Anti-Gag HIV-1 Monoclonal Antibodies Using Oligopeptides and their Cross-Reactivity with HIV-2. AIDS, 3:829-834, 1989. PubMed ID: 2483619. Show all entries for this paper.


Displaying record number 72

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MAb ID 1G5C8
HXB2 Location Gag(201-218)
DNA(1390..1443)
Gag Epitope Map
Author Location p24(201-218 BRU)
Epitope LKETINEEAAEWDRVHPV Epitope Alignment
LKETINEEAAEWDRVHPV epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component p24 Gag

Notes

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References

Showing 4 of 4 reference.

Janvier1990 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2. J. Virol., 64:4258-4263, 1990. PubMed ID: 1696638. Show all entries for this paper.

Janvier1992 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2 (Author's Correction). J. Virol., 66:613, 1992. Show all entries for this paper.

RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.

RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.


Displaying record number 103

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MAb ID 23A5G5
HXB2 Location Gag(285-304)
DNA(1642..1701)
Gag Epitope Map
Author Location p24(285-304 BRU)
Epitope IRQGPKEPFRDYVDRFYKTL Epitope Alignment
IRQGPKEPFRDYVDRFYKTL epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component p24 Gag

References

Showing 2 of 2 references.

RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.

RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.


Displaying record number 161

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MAb ID 8G5
HXB2 Location Pol(94-101)
DNA(2364..2387)
Pol Epitope Map
Author Location Protease(38-45 HXB2)
Epitope LPGRWKPK Epitope Alignment
LPGRWKPK epitope logo
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) hamster(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Protease

Notes

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References

Showing 1 of 1 reference.

Croix1993 D. A. Croix, H. Y. Yeh, J. Sedlacek, R. B. Luftig, and P. D. Gottlieb. A Dominant Epitope of HIV-1 Protease Recognized by Hamster Monoclonal Antibodies. J. Acquir. Immune Defic. Syndr., 6:558-566, 1993. PubMed ID: 8496788. Show all entries for this paper.


Displaying record number 196

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MAb ID 6G5
HXB2 Location Pol(716-731)
DNA(4230..4277)
Pol Epitope Map
Author Location Integrase(1-16 HXB2)
Epitope FLDGIDKAQDEHEKYH Epitope Alignment
FLDGIDKAQDEHEKYH epitope logo
Subtype B
Ab Type N-term
Neutralizing  
Species (Isotype) mouse(IgG1κ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade HXB2
Vaccine component Int

Notes

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References

Showing 1 of 1 reference.

Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.


Displaying record number 264

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MAb ID D/3G5
HXB2 Location Env(73-82)
DNA(6441..6470)
Env Epitope Map
Author Location gp120(73-82 LAI)
Epitope ACVPTDPNPQ Epitope Alignment
ACVPTDPNPQ epitope logo
Subtype B
Ab Type gp120 C1
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade LAI
Vaccine component gp120

Notes

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References

Showing 1 of 1 reference.

Bristow1994 R. G. W. Bristow, A. R. Douglas, J. J. Skehel, and R. S Daniels. Analysis of murine antibody responses to baculovirus-expressed human immunodeficiency virus type 1 envelope glycoproteins. J. Gen. Virol., 75:2089-2095, 1994. BALB/c mice were immunized with baculovirus expressed gp160 or gp120, and 15 MAbs were generated. No MAbs generated in this study neutralized reference strains, using a tetrazolium-based cytotoxicity assay to test for neutralization. Ten of the Mabs were mapped by peptide ELISA, and seven reacted with the C1 region, one with V2, one with V4, and one with the C-terminal end. PubMed ID: 7519249. Show all entries for this paper.


Displaying record number 4707

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MAb ID BG505.57
HXB2 Location Env(304-313)
DNA(7134..7163)
Env Epitope Map
Author Location  
Epitope RKSIRIGP Epitope Alignment
RKSIRIGP epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4706

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MAb ID BG505.56
HXB2 Location Env(304-313)
DNA(7134..7163)
Env Epitope Map
Author Location  
Epitope RKSIRIGP Epitope Alignment
RKSIRIGP epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4709

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MAb ID BG505.63
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4704

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MAb ID BG505.49
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4711

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MAb ID BG505.69
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4703

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MAb ID BG505.48
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4710

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MAb ID BG505.68
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4705

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MAb ID BG505.50
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4708

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MAb ID BG505.61
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4701

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MAb ID BG505.13
HXB2 Location Env(304-322)
DNA(7134..7190)
Env Epitope Map
Author Location  
Epitope RKSIRIGPGQAFYATGD Epitope Alignment
RKSIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4702

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MAb ID BG505.34
HXB2 Location Env(306-322)
DNA(7140..7190)
Env Epitope Map
Author Location  
Epitope SIRIGPGQAFYATGD Epitope Alignment
SIRIGPGQAFYATGD epitope logo
Subtype A1
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing    View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 803

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MAb ID 9G5A
HXB2 Location Env(591-594)
DNA(7995..8006)
Env Epitope Map
Author Location gp41(596-599 IIIB)
Epitope QLLG Epitope Alignment
QLLG epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgM)
Patient  
Immunogen anti-idiotype
Keywords  

Notes

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References

Showing 2 of 2 reference.

Beretta1994 A. Beretta and A.G. Dalgleish. B-Cell Epitopes. AIDS, 8(suppl 1):S133-S145, 1994. Show all entries for this paper.

Lopalco1993 L. Lopalco, R. Longhi, F. Ciccomascolo, A. De Rossi, M. Pelagi, F. Andronico, J. P. Moore, B T. Schulz, A. Beretta, and A. G. Siccardi. Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies. AIDS Res. Hum. Retroviruses, 9:33-39, 1993. The MAb M38 binds to the carboxy terminus of gp120, in a gp41 binding region. This MAb was used to create an anti-idiotype MAb, 9G5A, which can bind to gp41 at the base of the cysteine loop. The binding domains of these two monoclonals are consistent with the C5 domain of gp120 being able to bind to the gp41 cysteine loop. The MAb M38 also binds to human HLA molecules, in antigenic homology or possibly molecular mimicry. PubMed ID: 7678970. Show all entries for this paper.


Displaying record number 4712

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MAb ID BG505.23
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type gp120
Neutralizing    View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

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Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4713

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MAb ID BG505.25
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type gp120
Neutralizing    View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

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Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4714

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MAb ID BG505.36
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type gp120
Neutralizing    View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

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Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4715

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MAb ID BG505.42
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type  
Neutralizing    View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

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Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 4716

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MAb ID BG505.46
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type  
Neutralizing    View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody generation, antibody lineage, antibody sequence, autologous responses, binding affinity, effector function, germline, neutralization, polyclonal antibodies, responses in children

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


Displaying record number 886

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MAb ID Fab G5
HXB2 Location Env Env Epitope Map
Author Location gp41( LAI)
Epitope
Subtype B
Ab Type gp41 cluster III
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient G
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody sequence, review

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.


Displaying record number 1058

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MAb ID 52G5/B9
HXB2 Location Env Env Epitope Map
Author Location gp120(gp120 SF162)
Research Contact Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope
Subtype B
Ab Type  
Neutralizing no
Species (Isotype) transgenic mouse(IgG2κ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade SF162
Vaccine component gp120
Adjuvant Ribi adjuvant (MPL+TDM) (RIBI)

Notes

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References

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He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.


Displaying record number 1266

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MAb ID 4KG5 (4KG.5)
HXB2 Location Env Env Epitope Map
Author Location gp120( JR-FL)
Epitope
Subtype B
Ab Type gp120 V1-V2-V3
Neutralizing  
Species (Isotype) human(IgG)
Patient FDA2
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody interactions, antibody sequence, assay or method development, binding affinity, neutralization, structure, subtype comparisons, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Zwick2003a Michael B. Zwick, Robert Kelleher, Richard Jensen, Aran F. Labrijn, Meng Wang, Gerald V. Quinnan, Jr., Paul W. H. I. Parren, and Dennis R. Burton. A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12. J. Virol., 77(12):6965-6978, Jun 2003. PubMed ID: 12768015. Show all entries for this paper.

Selvarajah2005 Suganya Selvarajah, Bridget Puffer, Ralph Pantophlet, Mansun Law, Robert W. Doms, and Dennis R. Burton. Comparing Antigenicity and Immunogenicity of Engineered gp120. J. Virol., 79(19):12148-12163, Oct 2005. PubMed ID: 16160142. Show all entries for this paper.

Bowley2007 D. R. Bowley, A. F. Labrijn, M. B. Zwick, and D. R. Burton. Antigen Selection from an HIV-1 Immune Antibody Library Displayed on Yeast Yields Many Novel Antibodies Compared to Selection from the Same Library Displayed on Phage. Protein Eng. Des. Sel., 20(2):81-90, Feb 2007. PubMed ID: 17242026. Show all entries for this paper.

Cham2006 Fatim Cham, Peng Fei Zhang, Leo Heyndrickx, Peter Bouma, Ping Zhong, Herman Katinger, James Robinson, Guido van der Groen, and Gerald V. Quinnan, Jr. Neutralization and Infectivity Characteristics of Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Infected Donors Whose Sera Exhibit Broadly Cross-Reactive Neutralizing Activity. Virology, 347(1):36-51, 30 Mar 2006. PubMed ID: 16378633. Show all entries for this paper.


Displaying record number 1290

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MAb ID 11G5
HXB2 Location Env Env Epitope Map
Author Location gp160 (V3)(303-338)
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) human
Patient  
Immunogen  
Keywords  

Notes

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References

Showing 1 of 1 reference.

Callahan1991 Lawrence N. Callahan, Michael Phelan, Margherita Mallinson, and Michael A. Norcross. Dextran Sulfate Blocks Antibody Binding to the Principal Neutralizing Domain of Human Immunodeficiency Virus Type 1 without Interfering with gp120-CD4 Interactions. J. Virol., 65(3):1543-1550, Mar 1991. PubMed ID: 1995952. Show all entries for this paper.


Displaying record number 1668

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MAb ID 114-4G5
HXB2 Location Env Env Epitope Map
Author Location Env
Research Contact Julia L. Hurwitz, St. Jude Children's research Hospital, julia.hurwitz@stjude.org
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen  
Keywords variant cross-reactivity

Notes

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References

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Slobod2005 Karen S. Slobod, Chris Coleclough, Mattia Bonsignori, Scott A. Brown, Xiaoyan Zhan, Sherri Surman, Amy Zirkel, Bart G. Jones, Robert E. Sealy, John Stambas, Brita Brown, Timothy D. Lockey, Pamela J. Freiden, Peter C. Doherty, James L. Blanchard, Louis N. Martin, and Julia L. Hurwitz. HIV Vaccine Rationale, Design and Testing. Curr. HIV Res., 3(2):107-112, Apr 2005. PubMed ID: 15853717. Show all entries for this paper.


Displaying record number 2494

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MAb ID 2B10G5
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) llama
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, kinetics, neutralization, variant cross-reactivity

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Koh2010 Willie W. L. Koh, Soren Steffensen, Maria Gonzalez-Pajuelo, Bart Hoorelbeke, Andrea Gorlani, Agnieszka Szynol, Anna Forsman, Marlén M. I. Aasa-Chapman, Hans de Haard, Theo Verrips, and Robin A. Weiss. Generation of a Family-Specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1. J. Biol. Chem., 285(25):19116-19124, 18 Jun 2010. PubMed ID: 20400507. Show all entries for this paper.


Displaying record number 2821

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MAb ID NIH45-46G54W (NIH45-46 G54W, 45-46W,NIH45-46W)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords acute/early infection, anti-idiotype, antibody binding site, antibody generation, antibody interactions, antibody polyreactivity, assay or method development, autologous responses, binding affinity, broad neutralizer, computational prediction, effector function, elite controllers and/or long-term non-progressors, escape, glycosylation, immunotherapy, neutralization, polyclonal antibodies, rate of progression, review, SIV, structure, subtype comparisons, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Notes

Showing 26 of 26 notes.

References

Showing 26 of 26 references.

Isolation Paper
Diskin2011 Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.

Carbonetti2014 Sara Carbonetti, Brian G. Oliver, Jolene Glenn, Leonidas Stamatatos, and D. Noah Sather. Soluble HIV-1 Envelope Immunogens Derived from an Elite Neutralizer Elicit Cross-Reactive V1V2 Antibodies and Low Potency Neutralizing Antibodies. PLoS One, 9(1):e86905, 2014. PubMed ID: 24466285. Show all entries for this paper.

Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.

Gardner2016 Matthew R. Gardner, Christoph H. Fellinger, Neha R. Prasad, Amber S. Zhou, Hema R. Kondur, Vinita R. Joshi, Brian D. Quinlan, and Michael Farzan. CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies. J. Virol., 90(17):7822-7832, 1 Sep 2016. PubMed ID: 27334589. Show all entries for this paper.

Goo2012 Leslie Goo, Zahra Jalalian-Lechak, Barbra A. Richardson, and Julie Overbaugh. A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection. J. Virol., 86(19):10857-10861, Oct 2012. PubMed ID: 22837204. Show all entries for this paper.

Halper-Stromberg2016 Ariel Halper-Stromberg and Michel C Nussenzweig. Towards HIV-1 Remission: Potential Roles for Broadly Neutralizing Antibodies. J. Clin. Invest., 126(2):415-423, Feb 2016. PubMed ID: 26752643. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Julien2015 Jean-Philippe Julien, Jeong Hyun Lee, Gabriel Ozorowski, Yuanzi Hua, Alba Torrents de la Peña, Steven W. de Taeye, Travis Nieusma, Albert Cupo, Anila Yasmeen, Michael Golabek, Pavel Pugach, P. J. Klasse, John P. Moore, Rogier W. Sanders, Andrew B. Ward, and Ian A. Wilson. Design and Structure of Two HIV-1 Clade C SOSIP.664 Trimers That Increase the Arsenal of Native-Like Env Immunogens. Proc. Natl. Acad. Sci. U.S.A., 112(38):11947-11952, 22 Sep 2015. PubMed ID: 26372963. Show all entries for this paper.

Klein2012a Florian Klein, Ariel Halper-Stromberg, Joshua A. Horwitz, Henning Gruell, Johannes F. Scheid, Stylianos Bournazos, Hugo Mouquet, Linda A. Spatz, Ron Diskin, Alexander Abadir, Trinity Zang, Marcus Dorner, Eva Billerbeck, Rachael N. Labitt, Christian Gaebler, Paola M. Marcovecchio, Reha-Baris Incesu, Thomas R. Eisenreich, Paul D. Bieniasz, Michael S. Seaman, Pamela J. Bjorkman, Jeffrey V. Ravetch, Alexander Ploss, and Michel C. Nussenzweig. HIV Therapy by a Combination of Broadly Neutralizing Antibodies in Humanized Mice. Nature, 492(7427):118-122, 6 Dec 2012. PubMed ID: 23103874. Show all entries for this paper.

Mishra2020 Nitesh Mishra, Shaifali Sharma, Ayushman Dobhal, Sanjeev Kumar, Himanshi Chawla, Ravinder Singh, Bimal Kumar Das, Sushil Kumar Kabra, Rakesh Lodha, and Kalpana Luthra. A Rare Mutation in an Infant-Derived HIV-1 Envelope Glycoprotein Alters Interprotomer Stability and Susceptibility to Broadly Neutralizing Antibodies Targeting the Trimer Apex. J. Virol., 94(19), 15 Sep 2020. PubMed ID: 32669335. Show all entries for this paper.

Mishra2021 Nitesh Mishra, Sanjeev Kumar, Swarandeep Singh, Tanu Bansal, Nishkarsh Jain, Sumedha Saluja, Rajesh Kumar, Sankar Bhattacharyya, Jayanth Kumar Palanichamy, Riyaz Ahmad Mir, Subrata Sinha, and Kalpana Luthra. Cross-Neutralization of SARS-CoV-2 by HIV-1 Specific Broadly Neutralizing Antibodies and Polyclonal Plasma. PLoS Pathog., 17(9):e1009958, Sep 2021. PubMed ID: 34559854. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.

Mouquet2012a Hugo Mouquet, Louise Scharf, Zelda Euler, Yan Liu, Caroline Eden, Johannes F. Scheid, Ariel Halper-Stromberg, Priyanthi N. P. Gnanapragasam, Daniel I. R. Spencer, Michael S. Seaman, Hanneke Schuitemaker, Ten Feizi, Michel C. Nussenzweig, and Pamela J. Bjorkman. Complex-Type N-Glycan Recognition by Potent Broadly Neutralizing HIV Antibodies. Proc. Natl. Acad. Sci. U.S.A, 109(47):E3268-E3277, 20 Nov 2012. PubMed ID: 23115339. Show all entries for this paper.

Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.

Rosenberg2015 Yvonne Rosenberg, Markus Sack, David Montefiori, Celia Labranche, Mark Lewis, Lori Urban, Lingjun Mao, Rainer Fischer, and Xiaoming Jiang. Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques. PLoS One, 10(3):e0120451, 25 Mar 2015. PubMed ID: 25807114. Show all entries for this paper.

Sanders2013 Rogier W. Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J. Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de los Reyes, Thomas J. Ketas, Marit J. van Gils, C. Richter King, Ian A. Wilson, Andrew B. Ward, P. J. Klasse, and John P. Moore. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but not Non-Neutralizing Antibodies. PLoS Pathog., 9(9):e1003618, Sep 2013. PubMed ID: 24068931. Show all entries for this paper.

Sather2012 D. Noah Sather, Sara Carbonetti, Jenny Kehayia, Zane Kraft, Iliyana Mikell, Johannes F. Scheid, Florian Klein, and Leonidas Stamatatos. Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus. J. Virol., 86(23):12676-12685, Dec 2012. PubMed ID: 22973035. Show all entries for this paper.

Stefic2019 Karl Stefic, Mélanie Bouvin-Pley, Asma Essat, Clara Visdeloup, Alain Moreau, Cécile Goujard, Marie-Laure Chaix, Martine Braibant, Laurence Meyer, and Francis Barin. Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02\_AG Viruses with a Focus on Evolution over Time. J. Virol., 93(2), 15 Jan 2019. PubMed ID: 30404804. Show all entries for this paper.

Wang2018a Hongye Wang, Ting Yuan, Tingting Li, Yanpeng Li, Feng Qian, Chuanwu Zhu, Shujia Liang, Daniel Hoffmann, Ulf Dittmer, Binlian Sun, and Rongge Yang. Evaluation of Susceptibility of HIV-1 CRF01\_AE Variants to Neutralization by a Panel of Broadly Neutralizing Antibodies. Arch. Virol., 163(12):3303-3315, Dec 2018. PubMed ID: 30196320. Show all entries for this paper.

West2013 Anthony P. West, Jr., Louise Scharf, Joshua Horwitz, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. Computational Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify Potential Functional Epitope Residues. Proc. Natl. Acad. Sci. U.S.A., 110(26):10598-10603, 25 Jun 2013. PubMed ID: 23754383. Show all entries for this paper.

Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.

Beretta2018 Maxime Beretta, Alain Moreau, Mélanie Bouvin-Pley, Asma Essat, Cécile Goujard, Marie-Laure Chaix, Stéphane Hue, Laurence Meyer, Francis Barin, Martine Braibant, and ANRS 06 Primo Cohort. Phenotypic Properties of Envelope Glycoproteins of Transmitted HIV-1 Variants from Patients Belonging to Transmission Chains. AIDS, 32(14):1917-1926, 10 Sep 2018. PubMed ID: 29927786. Show all entries for this paper.

Berendam2021 Stella J. Berendam, Tiffany M. Styles, Papa K.. Morgan-Asiedu, DeAnna Tenney, Amit Kumar, Veronica Obregon-Perko, Katharine J. Bar, Kevin O. Saunders, Sampa Santra, Kristina De Paris, Georgia D. Tomaras, Ann Chahroudi, Sallie R. Permar, Rama R. Amara, and Genevieve G. Fouda. Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses. J. Virol., 95(3), 13 Jan 2021. PubMed ID: 33177194. Show all entries for this paper.

Moyo2018 Thandeka Moyo, June Ereño-Orbea, Rajesh Abraham Jacob, Clara E. Pavillet, Samuel Mundia Kariuki, Emily N. Tangie, Jean-Philippe Julien, and Jeffrey R. Dorfman. Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11. J. Virol., 92(14), 15 Jul 2018. PubMed ID: 29618644. Show all entries for this paper.


Displaying record number 3161

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MAb ID 45-46m2 (NIH45-46G54W.HC, S28Y.LC, m2)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, antibody polyreactivity, binding affinity, immunotherapy, neutralization, review, SIV, structure, subtype comparisons

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.

Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.

Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.


Displaying record number 3162

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MAb ID 45-46m7 (NIH45-46G54W,W47V.HC,S28Y.LC, m7)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, antibody polyreactivity, binding affinity, immunotherapy, neutralization, review, SIV, structure, subtype comparisons

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.

Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.

Barbian2015 Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Jr., Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, and Beatrice H. Hahn. Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. mBio, 6(2), 21 Apr 2015. PubMed ID: 25900654. Show all entries for this paper.


Displaying record number 3165

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MAb ID NIH45-46G54F (45-46F)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Diskin2011 Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520. Show all entries for this paper.


Displaying record number 3166

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MAb ID NIH45-46G54Y (45-46Y)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Diskin2011 Ron Diskin, Johannes F. Scheid, Paola M. Marcovecchio, Anthony P. West, Jr., Florian Klein, Han Gao, Priyanthi N. P. Gnanapragasam, Alexander Abadir, Michael S. Seaman, Michel C. Nussenzweig, and Pamela J. Bjorkman. Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334(6060):1289-1293, 2 Dec 2011. PubMed ID: 22033520. Show all entries for this paper.


Displaying record number 3167

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MAb ID 45-46m25 (NIH45-46G54W,W47I.HC,S28Y.LC, m25)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, immunotherapy, neutralization, review, structure, subtype comparisons

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.


Displaying record number 3175

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MAb ID 45-46m28 (NIH45-46G54W,W47T.HC,S28Y.LC, NIH45-46m28, m28)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, immunotherapy, neutralization, review, structure, subtype comparisons

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
Diskin2013 Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West, Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig, and Pamela J. Bjorkman. Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies. J. Exp. Med., 210(6):1235-1249, 3 Jun 2013. PubMed ID: 23712429. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.


Displaying record number 3229

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MAb ID VRC07G54W (VRC07-G54W)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing yes
Species (Isotype) human(IgG)
Patient NIH45
Immunogen  
Keywords antibody generation, antibody polyreactivity, autoantibody or autoimmunity, review, structure

Notes

Showing 6 of 6 notes.

References

Showing 7 of 7 references.

Balazs2013 Alejandro B. Balazs and Anthony P. West, Jr. Antibody Gene Transfer for HIV Immunoprophylaxis. Nat. Immunol., 14(1):1-5, Jan 2013. PubMed ID: 23238748. Show all entries for this paper.

Krebs2019 Shelly J. Krebs, Young D. Kwon, Chaim A. Schramm, William H. Law, Gina Donofrio, Kenneth H. Zhou, Syna Gift, Vincent Dussupt, Ivelin S. Georgiev, Sebastian Schätzle, Jonathan R. McDaniel, Yen-Ting Lai, Mallika Sastry, Baoshan Zhang, Marissa C. Jarosinski, Amy Ransier, Agnes L. Chenine, Mangaiarkarasi Asokan, Robert T. Bailer, Meera Bose, Alberto Cagigi, Evan M. Cale, Gwo-Yu Chuang, Samuel Darko, Jefferson I. Driscoll, Aliaksandr Druz, Jason Gorman, Farida Laboune, Mark K. Louder, Krisha McKee, Letzibeth Mendez, M. Anthony Moody, Anne Marie O'Sullivan, Christopher Owen, Dongjun Peng, Reda Rawi, Eric Sanders-Buell, Chen-Hsiang Shen, Andrea R. Shiakolas, Tyler Stephens, Yaroslav Tsybovsky, Courtney Tucker, Raffaello Verardi, Keyun Wang, Jing Zhou, Tongqing Zhou, George Georgiou, S Munir Alam, Barton F. Haynes, Morgane Rolland, Gary R. Matyas, Victoria R. Polonis, Adrian B. McDermott, Daniel C. Douek, Lawrence Shapiro, Sodsai Tovanabutra, Nelson L. Michael, John R. Mascola, Merlin L. Robb, Peter D. Kwong, and Nicole A. Doria-Rose. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50(3):677-691.e13, 19 Mar 2019. PubMed ID: 30876875. Show all entries for this paper.

Kwon2012a Y. Kwon, I. Georgiev, S. O'Dell, W. Shi, G. Chuang, Y. Yang, Zhang, J. Zhu, G. J. Nabel, J. R. Mascola, and P. D. Kwong. Structure-Guided Modification and Optimization of Antibody VRC07. Retrovirology, 9(s2):O34, 2012. Show all entries for this paper.

Liu2019 Qingbo Liu, Yen-Ting Lai, Peng Zhang, Mark K. Louder, Amarendra Pegu, Reda Rawi, Mangaiarkarasi Asokan, Xuejun Chen, Chen-Hsiang Shen, Gwo-Yu Chuang, Eun Sung Yang, Huiyi Miao, Yuge Wang, Anthony S. Fauci, Peter D. Kwong, John R. Mascola, and Paolo Lusso. Improvement of Antibody Functionality by Structure-Guided Paratope Engraftment. Nat. Commun., 10(1):721, 13 Feb 2019. PubMed ID: 30760721. Show all entries for this paper.

Rudicell2014 Rebecca S. Rudicell, Young Do Kwon, Sung-Youl Ko, Amarendra Pegu, Mark K. Louder, Ivelin S. Georgiev, Xueling Wu, Jiang Zhu, Jeffrey C. Boyington, Xuejun Chen, Wei Shi, Zhi-Yong Yang, Nicole A. Doria-Rose, Krisha McKee, Sijy O'Dell, Stephen D. Schmidt, Gwo-Yu Chuang, Aliaksandr Druz, Cinque Soto, Yongping Yang, Baoshan Zhang, Tongqing Zhou, John-Paul Todd, Krissey E. Lloyd, Joshua Eudailey, Kyle E. Roberts, Bruce R. Donald, Robert T. Bailer, Julie Ledgerwood, NISC Comparative Sequencing Program, James C. Mullikin, Lawrence Shapiro, Richard A. Koup, Barney S. Graham, Martha C. Nason, Mark Connors, Barton F. Haynes, Srinivas S. Rao, Mario Roederer, Peter D. Kwong, John R. Mascola, and Gary J. Nabel. Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J. Virol., 88(21):12669-12682, 1 Nov 2014. PubMed ID: 25142607. Show all entries for this paper.

Yang2014 Lili Yang and Pin Wang. Passive Immunization against HIV/AIDS by Antibody Gene Transfer. Viruses, 6(2):428-447, Feb 2014. PubMed ID: 24473340. Show all entries for this paper.

Kwon2023 Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, and Peter D. Kwong. Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain. MAbs, 15(1):2223350 doi, Jan-Dec 2023. PubMed ID: 37345226 Show all entries for this paper.


Displaying record number 4244

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MAb ID BG5
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient 391370
Immunogen HIV-1 infection
Country United States
Keywords antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, autoantibody or autoimmunity, broad neutralizer, contact residues, germline, immunotherapy, neutralization, polyclonal antibodies

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Barnes2022 Christopher O. Barnes, Till Schoofs, Priyanthi N. P. Gnanapragasam, Jovana Golijanin, Kathryn E. Huey-Tubman, Henning Gruell, Philipp Schommers, Nina Suh-Toma, Yu Erica Lee, Julio C. Cetrulo Lorenzi, Alicja Piechocka-Trocha, Johannes F. Scheid, Anthony P. West, Jr., Bruce D. Walker, Michael S. Seaman, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. A Naturally Arising Broad and Potent CD4-Binding Site Antibody with Low Somatic Mutation. Sci. Adv., 8(32):eabp8155, 12 Aug 2022. PubMed ID: 35960796. Show all entries for this paper.


Displaying record number 4247

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MAb ID BG24-G54W
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient 391370
Immunogen HIV-1 infection
Country United States
Keywords antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, autoantibody or autoimmunity, broad neutralizer, contact residues, germline, immunotherapy, neutralization, polyclonal antibodies

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Barnes2022 Christopher O. Barnes, Till Schoofs, Priyanthi N. P. Gnanapragasam, Jovana Golijanin, Kathryn E. Huey-Tubman, Henning Gruell, Philipp Schommers, Nina Suh-Toma, Yu Erica Lee, Julio C. Cetrulo Lorenzi, Alicja Piechocka-Trocha, Johannes F. Scheid, Anthony P. West, Jr., Bruce D. Walker, Michael S. Seaman, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. A Naturally Arising Broad and Potent CD4-Binding Site Antibody with Low Somatic Mutation. Sci. Adv., 8(32):eabp8155, 12 Aug 2022. PubMed ID: 35960796. Show all entries for this paper.


Displaying record number 4700

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MAb ID polyclonal BG505 M27 (polyclonal BG505 25.3 mo pi)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype A1
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human
Patient BG505
Immunogen HIV-1 infection
Country Kenya
Keywords antibody binding site, antibody generation, antibody lineage, autologous responses, broad neutralizer, neutralization, polyclonal antibodies, responses in children

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
Wu2006a Xueling Wu, Adam B. Parast, Barbra A. Richardson, Ruth Nduati, Grace John-Stewart, Dorothy Mbori-Ngacha, Stephanie M. J. Rainwater, and Julie Overbaugh. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol, 80(2):835-44 doi, Jan 2006. PubMed ID: 16378985 Show all entries for this paper.

Goo2014 Leslie Goo, Vrasha Chohan, Ruth Nduati, and Julie Overbaugh. Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat Med, 20(6):655-8 doi, Jun 2014. PubMed ID: 24859529 Show all entries for this paper.

Simonich2021 Cassandra Simonich, Mackenzie M. Shipley, Laura Doepker, Theodore Gobillot, Meghan Garrett, Evan M. Cale, Brianna Hennessy, Hannah Itell, Vrasha Chohan, Nicole Doria-Rose, Ruth Nduati, and Julie Overbaugh. A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505. Cell Rep. Med., 2(6):100314, 15 Jun 2021. PubMed ID: 34195680. Show all entries for this paper.


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