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HIV Molecular Immunology Database

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Found 29 matching records:

Displaying record number 179

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MAb ID 33D5
HXB2 Location Pol(449-473)
DNA(3429..3503)
Pol Epitope Map
Author Location RT(294-319)
Epitope PLTEEAELELAENREILKEPVHGVY Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type E. coli Trp fusion protein
Vaccine component RT

Notes

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References

Showing 1 of 1 reference.

Szilvay1992 A. M. Szilvay, S. Nornes, I. R. Haugan, L. Olsen, V. R. Prasad, C. Endresen, S. P. Goff, and D. E. Helland. Epitope Mapping of HIV-1 Reverse Transcriptase with Monoclonal Antibodies that Inhibit Polymerase and RNase H Activities. J. Acquir. Immune Defic. Syndr., 5:647-657, 1992. 20 MAbs are described, only five are able to bind to short peptides. These five MAbs are insensitive to mutations through out the rest of RT. PubMed ID: 1377241. Show all entries for this paper.


Displaying record number 224

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MAb ID 33 (mAb33, Fab33, 33D5, mab 33)
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(223-268 HXB2)
Epitope (Discontinuous epitope)
Subtype B
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords antibody binding site, computational prediction, mimotopes, review, structure

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Yi2000a Jizu Yi and Anna Marie Skalka. Mapping Epitopes of Monoclonal Antibodies Against HIV-1 Integrase with Limited Proteolysis and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Biopolymers, 55(4):308-318, 2000. PubMed ID: 11169922. Show all entries for this paper.

Yi2002 Jizu Yi, Hong Cheng, Mark D. Andrake, Roland L. Dunbrack, Jr., Heinrich Roder, and Anna Marie Skalka. Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-Terminal DNA-Binding Domain of HIV-1 Integrase. J. Biol. Chem., 277(14):12164-12174, 5 Apr 2002. PubMed ID: 11805085. Show all entries for this paper.

Schreiber2005 Andreas Schreiber, Michael Humbert, Alexander Benz, and Ursula Dietrich. 3D-Epitope-Explorer (3DEX): Localization of Conformational Epitopes within Three-Dimensional Structures of Proteins. J. Comput. Chem., 26(9):879-887, 15 Jul 2005. PubMed ID: 15834923. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 233

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MAb ID 1D9D5 (1D9)
HXB2 Location Tat(2-21)
DNA(5834..5893)
Tat Epitope Map
Author Location Tat
Epitope EPVDPRLEWKHPGSQPKTA Epitope Alignment
EPVDPRLEWKHPGSQPKTA epitope logo
Ab Type N-term
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords antibody interactions, binding affinity

Vaccine Details

Vaccine type protein
Vaccine component Tat

Notes

Showing 5 of 5 notes.

References

Showing 4 of 4 references.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

Mhashilkar1995 A. M. Mhashilkar, J. Bagley, S. Y. Chen, A. M. Szilvay, D. G. Helland, and W. A. Marasco. Inhibition of HIV-1 Tat-Mediated LTR Transactivation and HIV-1 Infection by Anti-Tat Single Chain Intrabodies. EMBO J., 14:1542-1551, 1995. Anti-Tat intrabodies specific for the N-terminal activation domain of Tat, block Tat-mediated transactivation of the HIV-1 LTR and intracellular trafficking of Tat in mammalian cells. Thus single chain intrabodies can effectively target molecules in the cytoplasm and nuclear compartments of eukaryotic cells and anti-Tat intrabodies may be useful for gene therapy of HIV-1 infection and AIDS. PubMed ID: 7537216. Show all entries for this paper.

Theisen2006 Dietmar M. Theisen, Carola Pongratz, Katja Wiegmann, Francisco Rivero, Oleg Krut, and Martin Krönke. Targeting of HIV-1 Tat Traffic and Function by Transduction-Competent Single Chain Antibodies. Vaccine, 24(16):3127-3136, 12 Apr 2006. PubMed ID: 16497417. Show all entries for this paper.

Valvatne1996 H. Valvatne, A. M. Szilvay, and D. E. Helland. A Monoclonal Antibody Defines a Novel HIV Type 1 Tat Domain Involved in Trans-Cellular Trans-Activation. AIDS Res. Hum. Retroviruses, 12:611-619, 1996. CAT and beta-galactosidase assays, and immunofluorescence analysis were used to study the cellular uptake of the HIV-1 Tat protein. A MAb binding to the basic domain and the RGD sequence inhibits trans- activation by exogenous Tat. The inhibition of the cellular uptake of Tat by an anti-Tat monoclonal antibody and by the serum components implies specific binding of Tat to the cell membrane. PubMed ID: 8743086. Show all entries for this paper.


Displaying record number 239

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MAb ID NT2/4D5.24
HXB2 Location Tat(73-86)
DNA(8380..8421)
Tat Epitope Map
Author Location Tat
Epitope PTSQPRGDPTGPKE Epitope Alignment
PTSQPRGDPTGPKE epitope logo
Ab Type C-term
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component Tat

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Dingwall1989 C. Dingwall, I. Ernberg, M. J. Gait, S. M. Green, S. Heaphy, J. Karn, A. D. Lowe, M. Singh, M. A. Skinner, and R. Valerio. Human Immunodeficiency Virus 1 Tat Protein Binds Trans-Activation-Responsive Region (TAR) RNA In Vitro. Proc. Natl. Acad. Sci. U.S.A., 86:6925-6929, 1989. PubMed ID: 2476805. Show all entries for this paper.


Displaying record number 1734

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MAb ID 7D5.1 (NT7 7D5.1)
HXB2 Location Tat Tat Epitope Map
Author Location Tat
Research Contact Dr. Jonathan Karn, AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen  
Keywords antibody binding site

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Karasev2005 Alexander V. Karasev, Scott Foulke, Candice Wellens, Amy Rich, Kyu J. Shon, Izabela Zwierzynski, David Hone, Hilary Koprowski, and Marvin Reitz. Plant Based HIV-1 Vaccine Candidate: Tat Protein Produced in Spinach. Vaccine, 23(15):1875-80, 7 Mar 2005. PubMed ID: 15734059. Show all entries for this paper.


Displaying record number 240

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MAb ID 2D9D5
HXB2 Location Tat Tat Epitope Map
Author Location Tat
Epitope
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Tat

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Mhashilkar1995 A. M. Mhashilkar, J. Bagley, S. Y. Chen, A. M. Szilvay, D. G. Helland, and W. A. Marasco. Inhibition of HIV-1 Tat-Mediated LTR Transactivation and HIV-1 Infection by Anti-Tat Single Chain Intrabodies. EMBO J., 14:1542-1551, 1995. Anti-Tat intrabodies specific for the N-terminal activation domain of Tat, block Tat-mediated transactivation of the HIV-1 LTR and intracellular trafficking of Tat in mammalian cells. Thus single chain intrabodies can effectively target molecules in the cytoplasm and nuclear compartments of eukaryotic cells and anti-Tat intrabodies may be useful for gene therapy of HIV-1 infection and AIDS. PubMed ID: 7537216. Show all entries for this paper.


Displaying record number 2050

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MAb ID 13D5
HXB2 Location Env(106-112)
DNA(6540..6560)
Env Epitope Map
Author Location Env
Epitope EDIISLW Epitope Alignment
EDIISLW epitope logo
Subtype C
Ab Type gp120 C1
Neutralizing no
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, neutralization, variant cross-reactivity

Vaccine Details

Vaccine type protein
Vaccine strain M group consensus
Vaccine component gp140ΔCFI

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Gao2009 Feng Gao, Richard M. Scearce, S. Munir Alam, Bhavna Hora, Shimao Xia, Julie E. Hohm, Robert J. Parks, Damon F. Ogburn, Georgia D. Tomaras, Emily Park, Woodrow E. Lomas, Vernon C. Maino, Susan A. Fiscus, Myron S. Cohen, M. Anthony Moody, Beatrice H. Hahn, Bette T. Korber, Hua-Xin Liao, and Barton F. Haynes. Cross-reactive Monoclonal Antibodies to Multiple HIV-1 Subtype and SIVcpz Envelope Glycoproteins. Virology, 394(1):91-98, 10 Nov 2009. PubMed ID: 19744690. Show all entries for this paper.

Meyerhoff2017 R. Ryan Meyerhoff, Richard M. Scearce, Damon F. Ogburn, Brad Lockwood, Joy Pickeral, Masa Kuraoka, Kara Anasti, Joshua Eudailey, Amanda Eaton, Melissa Cooper, Kevin Wiehe, David C. Montefiori, Georgia Tomaras, Guido Ferrari, S. Munir Alam, Hua-Xin Liao, Bette Korber, Feng Gao, and Barton F. Haynes. HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies. AIDS Res. Hum. Retroviruses, 33(8):859-868, Aug 2017. PubMed ID: 28314374. Show all entries for this paper.


Displaying record number 312

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MAb ID 6D5
HXB2 Location Env(122-141)
DNA(6588..6647)
Env Epitope Map
Author Location gp120(122-141 LAI)
Research Contact S. Nigida and L. Arthur, NCI, Frederick, MD USA
Epitope LTPLCVSLKCTDLKNDTNTN Epitope Alignment
LTPLCVSLKCTDLKNDTNTN epitope logo
Subtype B
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine strain B clade LAI
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 2 of 2 reference.

Moore1994a J. P. Moore, Q. J. Sattentau, R. Wyatt, and J. Sodroski. Probing the Structure of the Human Immunodeficiency Virus Surface Glycoprotein gp120 with a Panel of Monoclonal Antibodies. J. Virol., 68:469-484, 1994. This study compared a large number of MAbs that bind to linear epitopes of gp120, and compared binding affinities for: i) native and SDS-DDT denatured gp120, (clone BH10 of the LAI isolate expressed in CHO cells); ii) recombinant gp120 lacking the V1, V2, V3 loops; iii) a panel of 20 mer peptides; iv) a panel of gp120 mutants; and v) oligomeric versus monomeric gp120. The binding ratio of native versus denatured monomeric gp120 is included in the table in this database. These numbers should be considered with the following points in mind: a continuous epitope may be partially exposed on the surface; and a preparation of rgp120 is not homogeneous and contains fully folded, partly denatured, and some completely unfolded species, so the conformation of what is considered to be a native protein will not only reflect fully folded gp120. The authors suggest that a fivefold increase in the affinity for a MAb binding to denatured versus native gp120 indicates that the epitope is inaccessible in the native form. We also have included here information extracted from Moore et al's list of the gp120 mutations that reduced the binding of a particular MAb. In mapping of exposed regions of gp120, C2, C3, and C5 domain epitopes were found to bind preferentially to denatured gp120. V1, V2 and V3, part of C4, and the extreme carboxy terminus of C5 were exposed on the native monomer. In the oligomeric form of the molecule, only V2, V3 and part of C4 are well exposed as continuous epitopes. PubMed ID: 7504741. Show all entries for this paper.

Moore1994c J. P. Moore, R. L. Willey, G. K. Lewis, J. Robinson, and J. Sodroski. Immunological evidence for interactions between the first, second and fifth conserved domains of the gp120 surface glycoprotein of human immunodeficiency virus type 1. J. Virol., 68:6836-6847, 1994. Mutation 267N/Q in C2 region results in exposing the carboxy-terminal end gp120. PubMed ID: 7933065. Show all entries for this paper.


Displaying record number 481

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MAb ID D59/A2
HXB2 Location Env(309-318)
DNA(7149..7178)
Env Epitope Map
Author Location gp120(307-316 IIIB)
Epitope IQRGPGRAFV Epitope Alignment
IQRGPGRAFV epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component gp120

References

Showing 1 of 1 references.

Akerblom1990 L. Akerblom, J. Hinkula, P.-A. Broliden, B. Makitalo, T. Fridberger, J. Rosen, M. Villacres-Eriksson, B. Morein, and B. Wahren. Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gp120. AIDS, 4:953-960, 1990. PubMed ID: 1702001. Show all entries for this paper.


Displaying record number 807

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MAb ID D50
HXB2 Location Env(642-665)
DNA(8148..8219)
Env Epitope Map
Author Location gp41(642-665)
Research Contact Patricia Earl and Christopher Broder, NIH
Epitope IHSLIEESQNQQEKNEQELLELDK Epitope Alignment
Subtype B
Ab Type gp41 cluster II
Neutralizing no
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, antibody interactions, binding affinity, mimics, neutralization, review, vaccine antigen design

Vaccine Details

Vaccine type protein
Vaccine component Env dimers

Notes

Showing 17 of 17 notes.

References

Showing 17 of 17 references.

Isolation Paper
Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.

Bontjer2010 Ilja Bontjer, Mark Melchers, Dirk Eggink, Kathryn David, John P. Moore, Ben Berkhout, and Rogier W. Sanders. Stabilized HIV-1 Envelope Glycoprotein Trimers Lacking the V1V2 Domain, Obtained by Virus Evolution. J. Biol. Chem, 285(47):36456-36470, 19 Nov 2010. PubMed ID: 20826824. Show all entries for this paper.

Cognasse2009 Fabrice Cognasse, Hind Hamzeh-Cognasse, Julien Berthet, Pauline Damien, Frédéric Lucht, Bruno Pozzetto, and Olivier Garraud. Altered Release of Regulated upon Activation, Normal T-Cell Expressed and Secreted Protein from Human, Normal Platelets: Contribution of Distinct HIV-1MN gp41 Peptides. AIDS, 23(15):2057-2059, 24 Sep 2009. PubMed ID: 19654498. Show all entries for this paper.

deRosny2004 Eve de Rosny, Russell Vassell, Shibo Jiang, Renate Kunert, and Carol D. Weiss. Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes. J. Virol., 78(5):2627-2631, Mar 2004. PubMed ID: 14963170. Show all entries for this paper.

Earl1997 P. L. Earl, C. C. Broder, R. W. Doms, and B. Moss. Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein. J. Virol., 71:2674-84, 1997. PubMed ID: 9060620. Show all entries for this paper.

Haynes2005a Barton F. Haynes, M. Anthony Moody, Laurent Verkoczy, Garnett Kelsoe, and S. Munir Alam. Antibody Polyspecificity and Neutralization of HIV-1: A Hypothesis. Hum. Antibodies, 14(3-4):59-67, 2005. PubMed ID: 16720975. Show all entries for this paper.

Haynes2006a Barton F. Haynes and David C. Montefiori. Aiming to Induce Broadly Reactive Neutralizing Antibody Responses with HIV-1 Vaccine Candidates. Expert Rev. Vaccines, 5(4):579-595, Aug 2006. PubMed ID: 16989638. Show all entries for this paper.

Leaman2010 Daniel P. Leaman, Heather Kinkead, and Michael B. Zwick. In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1. J. Virol., 84(7):3382-3395, Apr 2010. PubMed ID: 20089658. Show all entries for this paper.

Nelson2008 Josh D. Nelson, Heather Kinkead, Florence M. Brunel, Dan Leaman, Richard Jensen, John M. Louis, Toshiaki Maruyama, Carole A. Bewley, Katherine Bowdish, G. Marius Clore, Philip E. Dawson, Shana Frederickson, Rose G. Mage, Douglas D. Richman, Dennis R. Burton, and Michael B. Zwick. Antibody Elicited against the gp41 N-Heptad Repeat (NHR) Coiled-Coil Can Neutralize HIV-1 with Modest Potency but Non-Neutralizing Antibodies Also Bind to NHR Mimetics. Virology, 377(1):170-183, 20 Jul 2008. PubMed ID: 18499210. Show all entries for this paper.

Pantophlet2009 Ralph Pantophlet, Meng Wang, Rowena O. Aguilar-Sino, and Dennis R. Burton. The Human Immunodeficiency Virus Type 1 Envelope Spike of Primary Viruses Can Suppress Antibody Access to Variable Regions. J. Virol., 83(4):1649-1659, Feb 2009. PubMed ID: 19036813. Show all entries for this paper.

Pietzsch2010 John Pietzsch, Johannes F. Scheid, Hugo Mouquet, Michael S. Seaman, Christopher C. Broder, and Michel C. Nussenzweig. Anti-gp41 Antibodies Cloned from HIV-Infected Patients with Broadly Neutralizing Serologic Activity. J. Virol., 84(10):5032-5042, May 2010. PubMed ID: 20219932. Show all entries for this paper.

Richardson1996 T. M. Richardson, Jr., B. L. Stryjewski, C. C. Broder, J. A. Hoxie, J. R. Mascola, P. L. Earl, and R. W. Doms. Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein. J. Virol., 70:753-62, 1996. An Env antigen capture enzyme-linked immunosorbent assay using a soluble, oligomeric form of HIV-1IIIB Env (gp140) that contains gp120 and the gp41 ectodomain was developed. The gp140, captured by various monoclonal antibodies (MAbs), retained its native oligomeric structure: it bound CD4 and was recognized by MAbs to conformational epitopes in gp120 and gp41, including oligomer-specific epitopes in gp41. PubMed ID: 8551612. Show all entries for this paper.

Srivastava2002 Indresh K. Srivastava, Leonidas Stamatatos, Harold Legg, Elaine Kan, Anne Fong, Stephen R. Coates, Louisa Leung, Mark Wininger, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Purification and Characterization of Oligomeric Envelope Glycoprotein from a Primary R5 Subtype B Human Immunodeficiency Virus. J. Virol., 76(6):2835-2847, Mar 2002. URL: http://jvi.asm.org/cgi/content/full/76/6/2835. PubMed ID: 11861851. Show all entries for this paper.

Yang2000 Xinzhen Yang, Michael Farzan, Richard Wyatt, and Joseph Sodroski. Characterization of Stable, Soluble Trimers Containing Complete Ectodomains of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins. J. Virol., 74(12):5716-5725, Jun 2000. PubMed ID: 10823881. Show all entries for this paper.

Zhang2008 Mei-Yun Zhang, Bang K. Vu, Anil Choudhary, Hong Lu, Michael Humbert, Helena Ong, Munir Alam, Ruth M. Ruprecht, Gerald Quinnan, Shibo Jiang, David C. Montefiori, John R. Mascola, Christopher C. Broder, Barton F. Haynes, and Dimiter S. Dimitrov. Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens. J. Virol., 82(14):6869-6879, Jul 2008. PubMed ID: 18480433. Show all entries for this paper.

Leaman2013 Daniel P. Leaman and Michael B. Zwick. Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution. PLoS Pathog., 9(2):e1003184, Feb 2013. PubMed ID: 23468626. Show all entries for this paper.


Displaying record number 2581

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MAb ID 12A12 (12A12d57)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient Patient 12
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody interactions, antibody lineage, antibody polyreactivity, antibody sequence, assay or method development, autologous responses, binding affinity, broad neutralizer, complement, computational prediction, early treatment, effector function, elite controllers and/or long-term non-progressors, escape, glycosylation, HIV reservoir/latency/provirus, HIV-2, immunoprophylaxis, immunotherapy, junction or fusion peptide, neutralization, polyclonal antibodies, review, structure, vaccine antigen design, vaccine-induced immune responses

Notes

Showing 33 of 33 notes.

References

Showing 33 of 33 references.

Isolation Paper
Scheid2011 Johannes F. Scheid, Hugo Mouquet, Beatrix Ueberheide, Ron Diskin, Florian Klein, Thiago Y. K. Oliveira, John Pietzsch, David Fenyo, Alexander Abadir, Klara Velinzon, Arlene Hurley, Sunnie Myung, Farid Boulad, Pascal Poignard, Dennis R. Burton, Florencia Pereyra, David D. Ho, Bruce D. Walker, Michael S. Seaman, Pamela J. Bjorkman, Brian T. Chait, and Michel C. Nussenzweig. Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding. Science, 333(6049):1633-1637, 16 Sep 2011. PubMed ID: 21764753. Show all entries for this paper.

Bonsignori2012b Mattia Bonsignori, S. Munir Alam, Hua-Xin Liao, Laurent Verkoczy, Georgia D. Tomaras, Barton F. Haynes, and M. Anthony Moody. HIV-1 Antibodies from Infection and Vaccination: Insights for Guiding Vaccine Design. Trends Microbiol., 20(11):532-539, Nov 2012. PubMed ID: 22981828. Show all entries for this paper.

Bonsignori2018 Mattia Bonsignori, Eric Scott, Kevin Wiehe, David Easterhoff, S. Munir Alam, Kwan-Ki Hwang, Melissa Cooper, Shi-Mao Xia, Ruijun Zhang, David C. Montefiori, Rory Henderson, Xiaoyan Nie, Garnett Kelsoe, M. Anthony Moody, Xuejun Chen, M. Gordon Joyce, Peter D. Kwong, Mark Connors, John R. Mascola, Andrew T. McGuire, Leonidas Stamatatos, Max Medina-Ramirez, Rogier W. Sanders, Kevin O. Saunders, Thomas B. Kepler, and Barton F. Haynes. Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity, 49(6):1162-1174.e8, 18 Dec 2018. PubMed ID: 30552024. Show all entries for this paper.

Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.

Briney2016 Bryan Briney, Devin Sok, Joseph G. Jardine, Daniel W. Kulp, Patrick Skog, Sergey Menis, Ronald Jacak, Oleksandr Kalyuzhniy, Natalia de Val, Fabian Sesterhenn, Khoa M. Le, Alejandra Ramos, Meaghan Jones, Karen L. Saye-Francisco, Tanya R. Blane, Skye Spencer, Erik Georgeson, Xiaozhen Hu, Gabriel Ozorowski, Yumiko Adachi, Michael Kubitz, Anita Sarkar, Ian A. Wilson, Andrew B. Ward, David Nemazee, Dennis R. Burton, and William R. Schief. Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell, 166(6):1459-1470.e11, 8 Sep 2016. PubMed ID: 27610570. Show all entries for this paper.

Bruel2016 Timothée Bruel, Florence Guivel-Benhassine, Sonia Amraoui, Marine Malbec, Léa Richard, Katia Bourdic, Daniel Aaron Donahue, Valérie Lorin, Nicoletta Casartelli, Nicolas Noël, Olivier Lambotte, Hugo Mouquet, and Olivier Schwartz. Elimination of HIV-1-Infected Cells by Broadly Neutralizing Antibodies. Nat. Commun., 7:10844, 3 Mar 2016. PubMed ID: 26936020. Show all entries for this paper.

Cai2017 Yongfei Cai, Selen Karaca-Griffin, Jia Chen, Sai Tian, Nicholas Fredette, Christine E. Linton, Sophia Rits-Volloch, Jianming Lu, Kshitij Wagh, James Theiler, Bette Korber, Michael S. Seaman, Stephen C. Harrison, Andrea Carfi, and Bing Chen. Antigenicity-Defined Conformations of an Extremely Neutralization-Resistant HIV-1 Envelope Spike. Proc. Natl. Acad. Sci. U.S.A., 114(17):4477-4482, 25 Apr 2017. PubMed ID: 28396421. Show all entries for this paper.

Chen2015 Jia Chen, James M. Kovacs, Hanqin Peng, Sophia Rits-Volloch, Jianming Lu, Donghyun Park, Elise Zablowsky, Michael S. Seaman, and Bing Chen. Effect of the Cytoplasmic Domain on Antigenic Characteristics of HIV-1 Envelope Glycoprotein. Science, 349(6244):191-195, 10 Jul 2015. PubMed ID: 26113642. Show all entries for this paper.

Chuang2020 Gwo-Yu Chuang, Mangaiarkarasi Asokan, Vera B. Ivleva, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Rajoshi Chaudhuri, Hui Geng, Bob C. Lin, Mark K. Louder, Krisha McKee, Sijy O'Dell, Hairong Wang, Tongqing Zhou, Nicole A. Doria-Rose, Lisa A. Kueltzo, Q. Paula Lei, John R. Mascola, and Peter D. Kwong. Removal of Variable Domain N-Linked Glycosylation as a Means To Improve the Homogeneity of HIV-1 Broadly Neutralizing Antibodies. mAbs, 12(1):1836719, 2020. PubMed ID: 33121334. Show all entries for this paper.

Danesh2020 Ali Danesh, Yanqin Ren, and R. Brad Jones. Roles of Fragment Crystallizable-Mediated Effector Functions in Broadly Neutralizing Antibody Activity against HIV. Curr. Opin. HIV AIDS, 15(5):316-323, Sep 2020. PubMed ID: 32732552. Show all entries for this paper.

Doria-Rose2017 Nicole A. Doria-Rose, Han R. Altae-Tran, Ryan S. Roark, Stephen D. Schmidt, Matthew S. Sutton, Mark K. Louder, Gwo-Yu Chuang, Robert T. Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S. Abdool Karim, James M. Binley, Mark Connors, Barton F. Haynes, Malcolm A. Martin, David C. Montefiori, Lynn Morris, Julie Overbaugh, Peter D. Kwong, John R. Mascola, and Ivelin S. Georgiev. Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting. PLoS Pathog., 13(1):e1006148, Jan 2017. PubMed ID: 28052137. Show all entries for this paper.

Georgiev2013 Ivelin S. Georgiev, Nicole A. Doria-Rose, Tongqing Zhou, Young Do Kwon, Ryan P. Staupe, Stephanie Moquin, Gwo-Yu Chuang, Mark K. Louder, Stephen D. Schmidt, Han R. Altae-Tran, Robert T. Bailer, Krisha McKee, Martha Nason, Sijy O'Dell, Gilad Ofek, Marie Pancera, Sanjay Srivatsan, Lawrence Shapiro, Mark Connors, Stephen A. Migueles, Lynn Morris, Yoshiaki Nishimura, Malcolm A. Martin, John R. Mascola, and Peter D. Kwong. Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization. Science, 340(6133):751-756, 10 May 2013. PubMed ID: 23661761. Show all entries for this paper.

Guzzo2018 Christina Guzzo, Peng Zhang, Qingbo Liu, Alice L. Kwon, Ferzan Uddin, Alexandra I. Wells, Hana Schmeisser, Raffaello Cimbro, Jinghe Huang, Nicole Doria-Rose, Stephen D. Schmidt, Michael A. Dolan, Mark Connors, John R. Mascola, and Paolo Lusso. Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation. mBio, 9(6), 11 Dec 2018. PubMed ID: 30538178. Show all entries for this paper.

Jardine2013 Joseph Jardine, Jean-Philippe Julien, Sergey Menis, Takayuki Ota, Oleksandr Kalyuzhniy, Andrew McGuire, Devin Sok, Po-Ssu Huang, Skye MacPherson, Meaghan Jones, Travis Nieusma, John Mathison, David Baker, Andrew B. Ward, Dennis R. Burton, Leonidas Stamatatos, David Nemazee, Ian A. Wilson, and William R. Schief. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors. Science, 340(6133):711-716, 10 May 2013. PubMed ID: 23539181. Show all entries for this paper.

Klein2013 Florian Klein, Ron Diskin, Johannes F. Scheid, Christian Gaebler, Hugo Mouquet, Ivelin S. Georgiev, Marie Pancera, Tongqing Zhou, Reha-Baris Incesu, Brooks Zhongzheng Fu, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Michael S. Seaman, Peter D. Kwong, Pamela J. Bjorkman, and Michel C. Nussenzweig. Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell, 153(1):126-138, 28 Mar 2013. PubMed ID: 23540694. Show all entries for this paper.

Kwong2012 Peter D. Kwong and John R. Mascola. Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies. Immunity, 37(3):412-425, 21 Sep 2012. PubMed ID: 22999947. Show all entries for this paper.

Kwong2018 Peter D. Kwong and John R. Mascola. HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure. Immunity, 48(5):855-871, 15 May 2018. PubMed ID: 29768174. Show all entries for this paper.

Lynch2012 Rebecca M. Lynch, Lillian Tran, Mark K. Louder, Stephen D. Schmidt, Myron Cohen, CHAVI 001 Clinical Team Members, Rebecca DerSimonian, Zelda Euler, Elin S. Gray, Salim Abdool Karim, Jennifer Kirchherr, David C. Montefiori, Sengeziwe Sibeko, Kelly Soderberg, Georgia Tomaras, Zhi-Yong Yang, Gary J. Nabel, Hanneke Schuitemaker, Lynn Morris, Barton F. Haynes, and John R. Mascola. The Development of CD4 Binding Site Antibodies during HIV-1 Infection. J. Virol., 86(14):7588-7595, Jul 2012. PubMed ID: 22573869. Show all entries for this paper.

Malbec2013 Marine Malbec, Françoise Porrot, Rejane Rua, Joshua Horwitz, Florian Klein, Ari Halper-Stromberg, Johannes F. Scheid, Caroline Eden, Hugo Mouquet, Michel C. Nussenzweig, and Olivier Schwartz. Broadly Neutralizing Antibodies That Inhibit HIV-1 Cell to Cell Transmission. J. Exp. Med., 210(13):2813-2821, 16 Dec 2013. PubMed ID: 24277152. Show all entries for this paper.

Mouquet2012a Hugo Mouquet, Louise Scharf, Zelda Euler, Yan Liu, Caroline Eden, Johannes F. Scheid, Ariel Halper-Stromberg, Priyanthi N. P. Gnanapragasam, Daniel I. R. Spencer, Michael S. Seaman, Hanneke Schuitemaker, Ten Feizi, Michel C. Nussenzweig, and Pamela J. Bjorkman. Complex-Type N-Glycan Recognition by Potent Broadly Neutralizing HIV Antibodies. Proc. Natl. Acad. Sci. U.S.A, 109(47):E3268-E3277, 20 Nov 2012. PubMed ID: 23115339. Show all entries for this paper.

Prigent2018 Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Ohlenschläger, Jordan D. Dimitrov, and Hugo Mouquet. Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity. Cell Rep., 23(9):2568-2581, 29 May 2018. PubMed ID: 29847789. Show all entries for this paper.

Sanders2013 Rogier W. Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J. Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de los Reyes, Thomas J. Ketas, Marit J. van Gils, C. Richter King, Ian A. Wilson, Andrew B. Ward, P. J. Klasse, and John P. Moore. A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but not Non-Neutralizing Antibodies. PLoS Pathog., 9(9):e1003618, Sep 2013. PubMed ID: 24068931. Show all entries for this paper.

Sather2012 D. Noah Sather, Sara Carbonetti, Jenny Kehayia, Zane Kraft, Iliyana Mikell, Johannes F. Scheid, Florian Klein, and Leonidas Stamatatos. Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus. J. Virol., 86(23):12676-12685, Dec 2012. PubMed ID: 22973035. Show all entries for this paper.

Scharf2016 Louise Scharf, Anthony P. West, Jr., Stuart A. Sievers, Courtney Chen, Siduo Jiang, Han Gao, Matthew D. Gray, Andrew T. McGuire, Johannes F. Scheid, Michel C. Nussenzweig, Leonidas Stamatatos, and Pamela J. Bjorkman. Structural Basis for Germline Antibody Recognition of HIV-1 Immunogens. Elife, 5, 21 Mar 2016. PubMed ID: 26997349. Show all entries for this paper.

Stewart-Jones2016 Guillaume B. E. Stewart-Jones, Cinque Soto, Thomas Lemmin, Gwo-Yu Chuang, Aliaksandr Druz, Rui Kong, Paul V. Thomas, Kshitij Wagh, Tongqing Zhou, Anna-Janina Behrens, Tatsiana Bylund, Chang W. Choi, Jack R. Davison, Ivelin S. Georgiev, M. Gordon Joyce, Young Do Kwon, Marie Pancera, Justin Taft, Yongping Yang, Baoshan Zhang, Sachin S. Shivatare, Vidya S. Shivatare, Chang-Chun D. Lee, Chung-Yi Wu, Carole A. Bewley, Dennis R. Burton, Wayne C. Koff, Mark Connors, Max Crispin, Ulrich Baxa, Bette T. Korber, Chi-Huey Wong, John R. Mascola, and Peter D. Kwong. Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. Cell, 165(4):813-826, 5 May 2016. PubMed ID: 27114034. Show all entries for this paper.

Walker2018 Laura M. Walker and Dennis R. Burton. Passive Immunotherapy of Viral Infections: `Super-Antibodies' Enter the Fray. Nat. Rev. Immunol., 18(5):297-308, May 2018. PubMed ID: 29379211. Show all entries for this paper.

West2012a Anthony P. West, Jr., Ron Diskin, Michel C. Nussenzweig, and Pamela J. Bjorkman. Structural Basis for Germ-Line Gene Usage of a Potent Class of Antibodies Targeting the CD4-Binding Site of HIV-1 gp120. Proc. Natl. Acad. Sci. U.S.A., 109(30):E2083-E2090, 24 Jul 2012. PubMed ID: 22745174. Show all entries for this paper.

West2013 Anthony P. West, Jr., Louise Scharf, Joshua Horwitz, Florian Klein, Michel C. Nussenzweig, and Pamela J. Bjorkman. Computational Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify Potential Functional Epitope Residues. Proc. Natl. Acad. Sci. U.S.A., 110(26):10598-10603, 25 Jun 2013. PubMed ID: 23754383. Show all entries for this paper.

Wu2015 Xueling Wu, Zhenhai Zhang, Chaim A. Schramm, M. Gordon Joyce, Young Do Kwon, Tongqing Zhou, Zizhang Sheng, Baoshan Zhang, Sijy O'Dell, Krisha McKee, Ivelin S. Georgiev, Gwo-Yu Chuang, Nancy S. Longo, Rebecca M. Lynch, Kevin O. Saunders, Cinque Soto, Sanjay Srivatsan, Yongping Yang, Robert T. Bailer, Mark K. Louder, NISC Comparative Sequencing Program, James C. Mullikin, Mark Connors, Peter D. Kwong, John R. Mascola, and Lawrence Shapiro. Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161(3):470-485, 23 Apr 2015. PubMed ID: 25865483. Show all entries for this paper.

Wu2016 Xueling Wu and Xiang-Peng Kong. Antigenic Landscape of the HIV-1 Envelope and New Immunological Concepts Defined by HIV-1 Broadly Neutralizing Antibodies. Curr. Opin. Immunol., 42:56-64, Oct 2016. PubMed ID: 27289425. Show all entries for this paper.

Zhou2013a Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang, Priyamvada Acharya, Ivelin S. Georgiev, Han R. Altae-Tran, Gwo-Yu Chuang, M. Gordon Joyce, Young Do Kwon, Nancy S. Longo, Mark K. Louder, Timothy Luongo, Krisha McKee, Chaim A. Schramm, Jeff Skinner, Yongping Yang, Zhongjia Yang, Zhenhai Zhang, Anqi Zheng, Mattia Bonsignori, Barton F. Haynes, Johannes F. Scheid, Michel C. Nussenzweig, Melissa Simek, Dennis R. Burton, Wayne C. Koff, NISC Comparative Sequencing Program, James C. Mullikin, Mark Connors, Lawrence Shapiro, Gary J. Nabel, John R. Mascola, and Peter D. Kwong. Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies. Immunity, 39(2):245-258, 22 Aug 2013. PubMed ID: 23911655. Show all entries for this paper.

Zhu2013a Jiang Zhu, Xueling Wu, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Cinque Soto, Tongqing Zhou, Joseph P. Casazza, NISC Comparative Sequencing Program, James C. Mullikin, Peter D. Kwong, John R. Mascola, and Lawrence Shapiro. De Novo Identification of VRC01 Class HIV-1-Neutralizing Antibodies by Next-Generation Sequencing of B-Cell Transcripts. Proc. Natl. Acad. Sci. U.S.A., 110(43):E4088-E4097, 22 Oct 2013. PubMed ID: 24106303. Show all entries for this paper.

Willis2022 Jordan R. Willis, Zachary T. Berndsen, Krystal M. Ma, Jon M. Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D. Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K. Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B. Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A. Wilson, John R. Yates III, James C. Paulson, Max Crispin, Andrew B. Ward, and William R. Schief. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity, 55(11):2149-2167e9 doi, Nov 2022. PubMed ID: 36179689 Show all entries for this paper.


Displaying record number 2627

Download this epitope record as JSON.

MAb ID 12A21 (12A21d57)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype CRF02_AG
Ab Type gp120 CD4bs
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient Patient 12
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody interactions, antibody lineage, antibody polyreactivity, antibody sequence, assay or method development, autologous responses, binding affinity, broad neutralizer, elite controllers and/or long-term non-progressors, escape, glycosylation, mutation acquisition, neutralization, polyclonal antibodies, rate of progression, review, structure

Notes

Showing 18 of 18 notes.

References

Showing 18 of 18 references.

Isolation Paper
Scheid2011 Johannes F. Scheid, Hugo Mouquet, Beatrix Ueberheide, Ron Diskin, Florian Klein, Thiago Y. K. Oliveira, John Pietzsch, David Fenyo, Alexander Abadir, Klara Velinzon, Arlene Hurley, Sunnie Myung, Farid Boulad, Pascal Poignard, Dennis R. Burton, Florencia Pereyra, David D. Ho, Bruce D. Walker, Michael S. Seaman, Pamela J. Bjorkman, Brian T. Chait, and Michel C. Nussenzweig. Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding. Science, 333(6049):1633-1637, 16 Sep 2011. PubMed ID: 21764753. Show all entries for this paper.

Hu2021 Yuanyuan Hu, Sen Zou, Zheng Wang, Ying Liu, Li Ren, Yanling Hao, Shasha Sun, Xintao Hu, Yuhua Ruan, Liying Ma, Yiming Shao, and Kunxue Hong. Virus Evolution and Neutralization Sensitivity in an HIV-1 Subtype B' Infected Plasma Donor with Broadly Neutralizing Activity. Vaccines (Basel), 9(4), 25 Mar 2021. PubMed ID: 33805985. Show all entries for this paper.

Jardine2016a Joseph G. Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin A. Scherer, Carole J. Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L. Saye-Francisco, Fabian Sesterhenn, Patrick C. Wilson, Denise M. Galloway, Robyn L. Stanfield, Ian A. Wilson, Dennis R. Burton, and William R. Schief. Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. PLoS Pathog, 12(8):e1005815, 25 Aug 2016. PubMed ID: 27560183. Show all entries for this paper.

Klein2013 Florian Klein, Ron Diskin, Johannes F. Scheid, Christian Gaebler, Hugo Mouquet, Ivelin S. Georgiev, Marie Pancera, Tongqing Zhou, Reha-Baris Incesu, Brooks Zhongzheng Fu, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Michael S. Seaman, Peter D. Kwong, Pamela J. Bjorkman, and Michel C. Nussenzweig. Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell, 153(1):126-138, 28 Mar 2013. PubMed ID: 23540694. Show all entries for this paper.

Kwong2012 Peter D. Kwong and John R. Mascola. Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies. Immunity, 37(3):412-425, 21 Sep 2012. PubMed ID: 22999947. Show all entries for this paper.

Lynch2012 Rebecca M. Lynch, Lillian Tran, Mark K. Louder, Stephen D. Schmidt, Myron Cohen, CHAVI 001 Clinical Team Members, Rebecca DerSimonian, Zelda Euler, Elin S. Gray, Salim Abdool Karim, Jennifer Kirchherr, David C. Montefiori, Sengeziwe Sibeko, Kelly Soderberg, Georgia Tomaras, Zhi-Yong Yang, Gary J. Nabel, Hanneke Schuitemaker, Lynn Morris, Barton F. Haynes, and John R. Mascola. The Development of CD4 Binding Site Antibodies during HIV-1 Infection. J. Virol., 86(14):7588-7595, Jul 2012. PubMed ID: 22573869. Show all entries for this paper.

McGuire2013 Andrew T. McGuire, Sam Hoot, Anita M. Dreyer, Adriana Lippy, Andrew Stuart, Kristen W. Cohen, Joseph Jardine, Sergey Menis, Johannes F. Scheid, Anthony P. West, William R. Schief, and Leonidas Stamatatos. Engineering HIV Envelope Protein To Activate Germline B Cell Receptors of Broadly Neutralizing Anti-CD4 Binding Site Antibodies. J. Exp. Med., 210(4):655-663, 8 Apr 2013. PubMed ID: 23530120. Show all entries for this paper.

McGuire2016 Andrew T. McGuire, Matthew D. Gray, Pia Dosenovic, Alexander D. Gitlin, Natalia T. Freund, John Petersen, Colin Correnti, William Johnsen, Robert Kegel, Andrew B. Stuart, Jolene Glenn, Michael S. Seaman, William R. Schief, Roland K. Strong, Michel C. Nussenzweig, and Leonidas Stamatatos. Specifically Modified Env Immunogens Activate B-Cell Precursors of Broadly Neutralizing HIV-1 Antibodies in Transgenic Mice. Nat. Commun., 7:10618, 24 Feb 2016. PubMed ID: 26907590. Show all entries for this paper.

Sather2012 D. Noah Sather, Sara Carbonetti, Jenny Kehayia, Zane Kraft, Iliyana Mikell, Johannes F. Scheid, Florian Klein, and Leonidas Stamatatos. Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus. J. Virol., 86(23):12676-12685, Dec 2012. PubMed ID: 22973035. Show all entries for this paper.

Scharf2016 Louise Scharf, Anthony P. West, Jr., Stuart A. Sievers, Courtney Chen, Siduo Jiang, Han Gao, Matthew D. Gray, Andrew T. McGuire, Johannes F. Scheid, Michel C. Nussenzweig, Leonidas Stamatatos, and Pamela J. Bjorkman. Structural Basis for Germline Antibody Recognition of HIV-1 Immunogens. Elife, 5, 21 Mar 2016. PubMed ID: 26997349. Show all entries for this paper.

vandenKerkhof2016 Tom L. G. M. van den Kerkhof, Steven W. de Taeye, Brigitte D. Boeser-Nunnink, Dennis R. Burton, Neeltje A. Kootstra, Hanneke Schuitemaker, Rogier W. Sanders, and Marit J. van Gils. HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds. Retrovirology, 13(1):48, 7 Jul 2016. PubMed ID: 27388013. Show all entries for this paper.

Walker2018 Laura M. Walker and Dennis R. Burton. Passive Immunotherapy of Viral Infections: `Super-Antibodies' Enter the Fray. Nat. Rev. Immunol., 18(5):297-308, May 2018. PubMed ID: 29379211. Show all entries for this paper.

Wang2022 Lijie Wang, Shujia Liang, Jianhua Huang, Yibo Ding, Lin He, Yanling Hao, Li Ren, Meiling Zhu, Yi Feng, Abdur Rashid, Yue Liu, Shibo Jiang, Kunxue Hong, and Liying Ma. Neutralization Sensitivity of HIV-1 CRF07\_BC From an Untreated Patient With a Focus on Evolution Over Time. Front. Cell. Infect. Microbiol., 12:862754, 2022. PubMed ID: 35372102. Show all entries for this paper.

West2012a Anthony P. West, Jr., Ron Diskin, Michel C. Nussenzweig, and Pamela J. Bjorkman. Structural Basis for Germ-Line Gene Usage of a Potent Class of Antibodies Targeting the CD4-Binding Site of HIV-1 gp120. Proc. Natl. Acad. Sci. U.S.A., 109(30):E2083-E2090, 24 Jul 2012. PubMed ID: 22745174. Show all entries for this paper.

Zhou2013a Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang, Priyamvada Acharya, Ivelin S. Georgiev, Han R. Altae-Tran, Gwo-Yu Chuang, M. Gordon Joyce, Young Do Kwon, Nancy S. Longo, Mark K. Louder, Timothy Luongo, Krisha McKee, Chaim A. Schramm, Jeff Skinner, Yongping Yang, Zhongjia Yang, Zhenhai Zhang, Anqi Zheng, Mattia Bonsignori, Barton F. Haynes, Johannes F. Scheid, Michel C. Nussenzweig, Melissa Simek, Dennis R. Burton, Wayne C. Koff, NISC Comparative Sequencing Program, James C. Mullikin, Mark Connors, Lawrence Shapiro, Gary J. Nabel, John R. Mascola, and Peter D. Kwong. Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies. Immunity, 39(2):245-258, 22 Aug 2013. PubMed ID: 23911655. Show all entries for this paper.

Zhou2015 Tongqing Zhou, Rebecca M. Lynch, Lei Chen, Priyamvada Acharya, Xueling Wu, Nicole A. Doria-Rose, M. Gordon Joyce, Daniel Lingwood, Cinque Soto, Robert T. Bailer, Michael J. Ernandes, Rui Kong, Nancy S. Longo, Mark K. Louder, Krisha McKee, Sijy O'Dell, Stephen D. Schmidt, Lillian Tran, Zhongjia Yang, Aliaksandr Druz, Timothy S. Luongo, Stephanie Moquin, Sanjay Srivatsan, Yongping Yang, Baoshan Zhang, Anqi Zheng, Marie Pancera, Tatsiana Kirys, Ivelin S. Georgiev, Tatyana Gindin, Hung-Pin Peng, An-Suei Yang, NISC Comparative Sequencing Program, James C. Mullikin, Matthew D. Gray, Leonidas Stamatatos, Dennis R. Burton, Wayne C. Koff, Myron S. Cohen, Barton F. Haynes, Joseph P. Casazza, Mark Connors, Davide Corti, Antonio Lanzavecchia, Quentin J. Sattentau, Robin A. Weiss, Anthony P. West, Jr., Pamela J. Bjorkman, Johannes F. Scheid, Michel C. Nussenzweig, Lawrence Shapiro, John R. Mascola, and Peter D. Kwong. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161(6):1280-1292, 4 Jun 2015. PubMed ID: 26004070. Show all entries for this paper.

Zhu2013a Jiang Zhu, Xueling Wu, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Cinque Soto, Tongqing Zhou, Joseph P. Casazza, NISC Comparative Sequencing Program, James C. Mullikin, Peter D. Kwong, John R. Mascola, and Lawrence Shapiro. De Novo Identification of VRC01 Class HIV-1-Neutralizing Antibodies by Next-Generation Sequencing of B-Cell Transcripts. Proc. Natl. Acad. Sci. U.S.A., 110(43):E4088-E4097, 22 Oct 2013. PubMed ID: 24106303. Show all entries for this paper.

Umotoy2019 Jeffrey Umotoy, Bernard S. Bagaya, Collin Joyce, Torben Schiffner, Sergey Menis, Karen L. Saye-Francisco, Trevor Biddle, Sanjay Mohan, Thomas Vollbrecht, Oleksander Kalyuzhniy, Sharon Madzorera, Dale Kitchin, Bronwen Lambson, Molati Nonyane, William Kilembe, IAVI Protocol C Investigators, IAVI African HIV Research Network, Pascal Poignard, William R. Schief, Dennis R. Burton, Ben Murrell, Penny L. Moore, Bryan Briney, Devin Sok, and Elise Landais. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. Immunity, 51(1):141-154.e6, 16 Jul 2019. PubMed ID: 31315032. Show all entries for this paper.


Displaying record number 2910

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MAb ID 1D5C (scFvs 1D5C)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype C
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) human(IgG)
Patient  
Immunogen HIV-1 infection
Country India
Keywords antibody generation

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Kumar2012 Rajesh Kumar, Raiees Andrabi, Ashutosh Tiwari, Somi Sankaran Prakash, Naveet Wig, Durgashree Dutta, Anurag Sankhyan, Lubina Khan, Subrata Sinha, and Kalpana Luthra. A Novel Strategy for Efficient Production of Anti-V3 Human scFvs against HIV-1 Clade C. BMC Biotechnol., 12:87, 2012. PubMed ID: 23153214. Show all entries for this paper.


Displaying record number 3265

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MAb ID 82D5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing P (tier 2)
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, effector function, neutralization

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3275

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MAb ID 39D5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG3κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 4240

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MAb ID 438-D5 (D5)
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1)
Patient CBJC438
Immunogen HIV-1 infection
Country China
Keywords antibody binding site, antibody generation, antibody lineage, binding affinity, broad neutralizer, germline, glycosylation, mutation acquisition, neutralization, structure

Notes

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References

Showing 1 of 1 reference.

Isolation Paper
Kumar2020 Sonu Kumar, Bin Ju, Benjamin Shapero, Xiaohe Lin, Li Ren, Lei Zhang, Dan Li, Zehua Zhou, Yi Feng, Cindy Sou, Colin J. Mann, Yanling Hao, Anita Sarkar, Jiali Hou, Christian Nunnally, Kunxue Hong, Shuo Wang, Xiangyang Ge, Bin Su, Elise Landais, Devin Sok, Michael B. Zwick, Linling He, Jiang Zhu, Ian A. Wilson, and Yiming Shao. A VH1-69 Antibody Lineage from an Infected Chinese Donor Potently Neutralizes HIV-1 by Targeting the V3 Glycan Supersite. Sci. Adv., 6(38), 16 Sep 2020. PubMed ID: 32938661. Show all entries for this paper.


Displaying record number 4657

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MAb ID D5_AR (D5_H011_L0)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp41 NHR (N-heptad repeat)
Neutralizing weak  View neutralization details
Species (Isotype) human(IgG)
Patient  
Immunogen HIV-1 infection
Keywords antibody generation, antibody sequence, binding affinity, effector function, mimics, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Rubio2021 Adonis A. Rubio, Maria V. Filsinger Interrante, Benjamin N. Bell, Clayton L. Brown, Theodora U. J. Bruun, Celia C. LaBranche, David C. Montefiori, and Peter S. Kim. A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity. J. Virol., 95(15):e0235020, 12 Jul 2021. PubMed ID: 33980592. Show all entries for this paper.

Kim2023 Soohyun Kim, Maria V. Filsinger Interrante, and Peter S. Kim. Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies. J. Virol., 97(1):e0164722, 31 Jan 2023. PubMed ID: 36541800. Show all entries for this paper.


Displaying record number 2500

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MAb ID 2B10D5
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) llama
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, kinetics, neutralization, variant cross-reactivity

Notes

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References

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Koh2010 Willie W. L. Koh, Soren Steffensen, Maria Gonzalez-Pajuelo, Bart Hoorelbeke, Andrea Gorlani, Agnieszka Szynol, Anna Forsman, Marlén M. I. Aasa-Chapman, Hans de Haard, Theo Verrips, and Robin A. Weiss. Generation of a Family-Specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1. J. Biol. Chem., 285(25):19116-19124, 18 Jun 2010. PubMed ID: 20400507. Show all entries for this paper.


Displaying record number 872

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MAb ID Fab D5 (D5)
HXB2 Location Env Env Epitope Map
Author Location gp41( LAI)
Epitope
Subtype B
Ab Type gp41 cluster II
Neutralizing no
Species (Isotype) human(IgG1κ)
Patient D
Immunogen HIV-1 infection
Keywords antibody binding site, antibody sequence, review

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.


Displaying record number 950

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MAb ID 3D5
HXB2 Location Env Env Epitope Map
Author Location Env
Research Contact Herman Katinger, Inst. Appl. Microbiol. University of Agricultural Science, Vienna, Austria
Epitope
Ab Type  
Neutralizing L
Species (Isotype) human
Patient  
Immunogen HIV-1 infection
Keywords antibody sequence

Notes

Showing 3 of 3 notes.

References

Showing 2 of 2 references.

Buchacher1994 A. Buchacher, R. Predl, K. Strutzenberger, W. Steinfellner, A. Trkola, M. Purtscher, G. Gruber, C. Tauer, F. Steindl, A. Jungbauer, and H. Katinger. Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization. AIDS Res. Hum. Retroviruses, 10:359-369, 1994. A panel of 33 human monoclonal antibodies were produced. Linear epitopes for some of this set of MAbs were mapped using peptide ELISA. Linear epitopes were mapped in gp41, and a single epitope was mapped in p24. While multiple gp120 specific MAbs were generated, all seemed to be conformational or carbohydrate dependent, or both. PubMed ID: 7520721. Show all entries for this paper.

Kunert1998 R. Kunert, F. Ruker, and H. Katinger. Molecular Characterization of Five Neutralizing Anti-HIV Type 1 Antibodies: Identification of Nonconventional D Segments in the Human Monoclonal Antibodies 2G12 and 2F5. AIDS Res. Hum. Retroviruses, 14:1115-1128, 1998. Study identifies five human MAbs which were able to neutralize primary isolates of different clades in vitro and reports the nucleotide and amino acid sequences of the heavy and light chain V segments of the antibodies. PubMed ID: 9737583. Show all entries for this paper.


Displaying record number 990

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MAb ID D52
HXB2 Location Env Env Epitope Map
Author Location gp120( IIIB)
Research Contact P. Earl, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
Epitope
Ab Type gp120 CD4bs
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component oligomeric gp140

Notes

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References

Showing 2 of 2 references.

Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Sugiura1999 W. Sugiura, C. C. Broder, B. Moss, and P. L. Earl. Characterization of conformation-dependent anti-gp120 murine monoclonal antibodies produced by immunization with monomeric and oligomeric human immunodeficiency virus type 1 envelope proteins. Virology, 254:257-67, 1999. PubMed ID: 9986792. Show all entries for this paper.


Displaying record number 991

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MAb ID D53
HXB2 Location Env Env Epitope Map
Author Location gp120( IIIB)
Research Contact P. Earl, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
Epitope
Ab Type gp120 CD4bs
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component oligomeric gp140

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Sugiura1999 W. Sugiura, C. C. Broder, B. Moss, and P. L. Earl. Characterization of conformation-dependent anti-gp120 murine monoclonal antibodies produced by immunization with monomeric and oligomeric human immunodeficiency virus type 1 envelope proteins. Virology, 254:257-67, 1999. PubMed ID: 9986792. Show all entries for this paper.


Displaying record number 995

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MAb ID D56
HXB2 Location Env Env Epitope Map
Author Location gp120( IIIB)
Research Contact P. Earl, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
Epitope
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component oligomeric gp140

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Sugiura1999 W. Sugiura, C. C. Broder, B. Moss, and P. L. Earl. Characterization of conformation-dependent anti-gp120 murine monoclonal antibodies produced by immunization with monomeric and oligomeric human immunodeficiency virus type 1 envelope proteins. Virology, 254:257-67, 1999. PubMed ID: 9986792. Show all entries for this paper.


Displaying record number 1050

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MAb ID 55D5/F9
HXB2 Location Env Env Epitope Map
Author Location gp120(gp120 SF162)
Research Contact Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing L
Species (Isotype) transgenic mouse(IgG2κ)
Patient  
Immunogen vaccine
Keywords review, variant cross-reactivity

Vaccine Details

Vaccine type protein
Vaccine strain B clade SF162
Vaccine component gp120
Adjuvant Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.


Displaying record number 1051

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MAb ID 46D2/D5
HXB2 Location Env Env Epitope Map
Author Location gp120(gp120 SF162)
Research Contact Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope
Subtype B
Ab Type gp120 CD4bs
Neutralizing no
Species (Isotype) transgenic mouse(IgG2κ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade SF162
Vaccine component gp120
Adjuvant Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.


Displaying record number 1710

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MAb ID D5 (5H/I1-BMV-D5)
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41 NHR (N-heptad repeat), gp41 six-helix bundle, gp41 five-helix bundle (one CHR of six helix bundle missing)
Neutralizing weak  View neutralization details
Species (Isotype) human(IgG1)
Patient  
Immunogen in vitro stimulation or selection
Keywords antibody binding site, antibody interactions, antibody lineage, assay or method development, binding affinity, effector function, kinetics, mimics, neutralization, review, structure, vaccine antigen design, vaccine-induced immune responses, variant cross-reactivity

Notes

Showing 23 of 23 notes.

References

Showing 23 of 23 references.

Isolation Paper
Miller2005 Michael D. Miller, Romas Geleziunas, Elisabetta Bianchi, Simon Lennard, Renee Hrin, Hangchun Zhang, Meiqing Lu, Zhiqiang An, Paolo Ingallinella, Marco Finotto, Marco Mattu, Adam C. Finnefrock, David Bramhill, James Cook, Debra M. Eckert, Richard Hampton, Mayuri Patel, Stephen Jarantow, Joseph Joyce, Gennaro Ciliberto, Riccardo Cortese, Ping Lu, William Strohl, William Schleif, Michael McElhaugh, Steven Lane, Christopher Lloyd, David Lowe, Jane Osbourn, Tristan Vaughan, Emilio Emini, Gaetano Barbato, Peter S. Kim, Daria J. Hazuda, John W. Shiver, and Antonello Pessi. A Human Monoclonal Antibody Neutralizes Diverse HIV-1 Isolates By Binding a Critical gp41 Epitope. Proc. Natl. Acad. Sci. U.S.A., 102(41):14759-14764, 11 Oct 2005. PubMed ID: 16203977. Show all entries for this paper.

Bianchi2010 Elisabetta Bianchi, Joseph G. Joyce, Michael D. Miller, Adam C. Finnefrock, Xiaoping Liang, Marco Finotto, Paolo Ingallinella, Philip McKenna, Michael Citron, Elizabeth Ottinger, Robert W. Hepler, Renee Hrin, Deborah Nahas, Chengwei Wu, David Montefiori, John W. Shiver, Antonello Pessi, and Peter S. Kim. Vaccination with Peptide Mimetics of the gp41 Prehairpin Fusion Intermediate Yields Neutralizing Antisera against HIV-1 Isolates. Proc. Natl. Acad. Sci. U.S.A., 107(23):10655-10660, 8 Jun 2010. PubMed ID: 20483992. Show all entries for this paper.

Caulfield2010 Michael J. Caulfield, Vadim Y. Dudkin, Elizabeth A. Ottinger, Krista L. Getty, Paul D. Zuck, Robin M. Kaufhold, Robert W. Hepler, Georgia B. McGaughey, Michael Citron, Renee C. Hrin, Ying-Jie Wang, Michael D. Miller, and Joseph G. Joyce. Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate As Vaccine Leads. J. Biol. Chem., 285(52):40604-40611, 24 Dec 2010. PubMed ID: 20943652. Show all entries for this paper.

DaSilva2010 Gustavo F. Da Silva, Joseph S. Harrison, and Jonathan R. Lai. Contribution of Light Chain Residues to High Affinity Binding in an HIV-1 Antibody Explored by Combinatorial Scanning Mutagenesis. Biochemistry, 49(26):5464-5472, 6 Jul 2010. PubMed ID: 20518570. Show all entries for this paper.

Eckert2008 Debra M. Eckert, Yu Shi, Sunghwan Kim, Brett D. Welch, Eunchai Kang, Emily S. Poff, and Michael S. Kay. Characterization of the Steric Defense of the HIV-1 gp41 N-Trimer Region. Protein Sci., 17(12):2091-2100, Dec 2008. PubMed ID: 18802030. Show all entries for this paper.

Gustchina2007 Elena Gustchina, John M. Louis, Son N. Lam, Carole A. Bewley, and G. Marius Clore. A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains. J. Virol., 81(23):12946-12953, Dec 2007. PubMed ID: 17898046. Show all entries for this paper.

Gustchina2010 Elena Gustchina, Mi Li, John M. Louis, D. Eric Anderson, John Lloyd, Christian Frisch, Carole A. Bewley, Alla Gustchina, Alexander Wlodawer, and G. Marius Clore. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41. PLoS Pathog., 6(11):e1001182, 2010. PubMed ID: 21085615. Show all entries for this paper.

Hartono2012 Yossa Dwi Hartono, Raudah Lazim, Yew Mun Yip, and Dawei Zhang. Computational Study of Bindings of HK20 Fab and D5 Fab to HIV-1 gp41. Bioorg. Med. Chem. Lett., 22(4):1695-1700, 15 Feb 2012. PubMed ID: 22260771. Show all entries for this paper.

Hrin2008 Renee Hrin, Donna L. Montgomery, Fubao Wang, Jon H. Condra, Zhiqiang An, William R. Strohl, Elisabetta Bianchi, Antonello Pessi, Joseph G. Joyce, and Ying-Jie Wang. Short Communication: In Vitro Synergy between Peptides or Neutralizing Antibodies Targeting the N- and C-Terminal Heptad Repeats of HIV Type 1 gp41. AIDS Res. Hum. Retroviruses, 24(12):1537-1544, Dec 2008. PubMed ID: 19102685. Show all entries for this paper.

Klein2013 Florian Klein, Ron Diskin, Johannes F. Scheid, Christian Gaebler, Hugo Mouquet, Ivelin S. Georgiev, Marie Pancera, Tongqing Zhou, Reha-Baris Incesu, Brooks Zhongzheng Fu, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Michael S. Seaman, Peter D. Kwong, Pamela J. Bjorkman, and Michel C. Nussenzweig. Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell, 153(1):126-138, 28 Mar 2013. PubMed ID: 23540694. Show all entries for this paper.

Kwong2009a Peter D. Kwong and Ian A. Wilson. HIV-1 and Influenza Antibodies: Seeing Antigens in New Ways. Nat. Immunol., 10(6):573-578, Jun 2009. PubMed ID: 19448659. Show all entries for this paper.

Kwong2011 Peter D. Kwong, John R. Mascola, and Gary J. Nabel. Rational Design of Vaccines to Elicit Broadly Neutralizing Antibodies to HIV-1. Cold Spring Harb. Perspect. Med., 1(1):a007278, Sep 2011. PubMed ID: 22229123. Show all entries for this paper.

Leaman2010 Daniel P. Leaman, Heather Kinkead, and Michael B. Zwick. In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1. J. Virol., 84(7):3382-3395, Apr 2010. PubMed ID: 20089658. Show all entries for this paper.

Lin2007 George Lin and Peter L. Nara. Designing Immunogens to Elicit Broadly Neutralizing Antibodies to the HIV-1 Envelope Glycoprotein. Curr. HIV Res., 5(6):514-541, Nov 2007. PubMed ID: 18045109. Show all entries for this paper.

Luftig2006 Micah A. Luftig, Marco Mattu, Paolo Di Giovine, Romas Geleziunas, Renee Hrin, Gaetano Barbato, Elisabetta Bianchi, Michael D. Miller, Antonello Pessi, and Andrea Carfi. Structural Basis for HIV-1 Neutralization by a gp41 Fusion Intermediate-Directed Antibody. Nat. Struct. Mol. Biol., 13(8):740-747, Aug 2006. PubMed ID: 16862157. Show all entries for this paper.

Montgomery2009 Donna L. Montgomery, Ying-Jie Wang, Renee Hrin, Micah Luftig, Bin Su, Michael D. Miller, Fubao Wang, Peter Haytko, Lingyi Huang, Salvatore Vitelli, Jon Condra, Xiaomei Liu, Richard Hampton, Andrea Carfi, Antonello Pessi, Elisabetta Bianchi, Joseph Joyce, Chris Lloyd, Romas Geleziunas, David Bramhill, Vicki M. King, Adam C. Finnefrock, William Strohl, and Zhiqiang An. Affinity Maturation and Characterization of a Human Monoclonal Antibody against HIV-1 gp41. MAbs, 1(5):462-474, Sep-Oct 2009. PubMed ID: 20065653. Show all entries for this paper.

Nelson2008 Josh D. Nelson, Heather Kinkead, Florence M. Brunel, Dan Leaman, Richard Jensen, John M. Louis, Toshiaki Maruyama, Carole A. Bewley, Katherine Bowdish, G. Marius Clore, Philip E. Dawson, Shana Frederickson, Rose G. Mage, Douglas D. Richman, Dennis R. Burton, and Michael B. Zwick. Antibody Elicited against the gp41 N-Heptad Repeat (NHR) Coiled-Coil Can Neutralize HIV-1 with Modest Potency but Non-Neutralizing Antibodies Also Bind to NHR Mimetics. Virology, 377(1):170-183, 20 Jul 2008. PubMed ID: 18499210. Show all entries for this paper.

Pantophlet2010 Ralph Pantophlet. Antibody Epitope Exposure and Neutralization of HIV-1. Curr. Pharm. Des., 16(33):3729-3743, 2010. PubMed ID: 21128886. Show all entries for this paper.

Phogat2007 S. Phogat, R. T. Wyatt, and G. B. Karlsson Hedestam. Inhibition of HIV-1 Entry by Antibodies: Potential Viral and Cellular Targets. J. Intern. Med., 262(1):26-43, Jul 2007. PubMed ID: 17598813. Show all entries for this paper.

Rubio2021 Adonis A. Rubio, Maria V. Filsinger Interrante, Benjamin N. Bell, Clayton L. Brown, Theodora U. J. Bruun, Celia C. LaBranche, David C. Montefiori, and Peter S. Kim. A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity. J. Virol., 95(15):e0235020, 12 Jul 2021. PubMed ID: 33980592. Show all entries for this paper.

Sabin2010 Charles Sabin, Davide Corti, Victor Buzon, Mike S. Seaman, David Lutje Hulsik, Andreas Hinz, Fabrizia Vanzetta, Gloria Agatic, Chiara Silacci, Lara Mainetti, Gabriella Scarlatti, Federica Sallusto, Robin Weiss, Antonio Lanzavecchia, and Winfried Weissenhorn. Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41. PLoS Pathog., 6(11):e1001195, 2010. PubMed ID: 21124990. Show all entries for this paper.

Vincent2012 Nadine Vincent and Etienne Malvoisin. Ability of Antibodies Specific to the HIV-1 Envelope Glycoprotein to Block the Fusion Inhibitor T20 in a Cell-Cell Fusion Assay. Immunobiology, 217(10):943-950, Oct 2012. PubMed ID: 22387075. Show all entries for this paper.

Zhou2010 Tongqing Zhou, Ivelin Georgiev, Xueling Wu, Zhi-Yong Yang, Kaifan Dai, Andrés Finzi, Young Do Kwon, Johannes F. Scheid, Wei Shi, Ling Xu, Yongping Yang, Jiang Zhu, Michel C. Nussenzweig, Joseph Sodroski, Lawrence Shapiro, Gary J. Nabel, John R. Mascola, and Peter D. Kwong. Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01. Science, 329(5993):811-817, 13 Aug 2010. PubMed ID: 20616231. Show all entries for this paper.


Displaying record number 2507

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MAb ID 2C7D5
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) llama
Patient  
Immunogen in vitro stimulation or selection
Keywords neutralization, variant cross-reactivity

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Koh2010 Willie W. L. Koh, Soren Steffensen, Maria Gonzalez-Pajuelo, Bart Hoorelbeke, Andrea Gorlani, Agnieszka Szynol, Anna Forsman, Marlén M. I. Aasa-Chapman, Hans de Haard, Theo Verrips, and Robin A. Weiss. Generation of a Family-Specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1. J. Biol. Chem., 285(25):19116-19124, 18 Jun 2010. PubMed ID: 20400507. Show all entries for this paper.


Displaying record number 3752

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MAb ID 36D5
HXB2 Location SIV proteins SIV proteins Epitope Map
Author Location  
Epitope
Ab Type gp120 V3 // V3 glycan (V3g), gp120 CCR5bs
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain SIV
Vaccine component gp140

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Edinger2000 Aimee L. Edinger, Ména Ahuja, Tina Sung, Kelly C. Baxter, Beth Haggarty, Robert W. Doms, and James A. Hoxie. Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein. J. Virol., 74(17):7922-7935, Sep 2000. PubMed ID: 10933700. Show all entries for this paper.

Swanstrom2016 Adrienne E. Swanstrom, Beth Haggarty, Andrea P. O. Jordan, Josephine Romano, George J. Leslie, Pyone P. Aye, Preston A. Marx, Andrew A. Lackner, Gregory Q. Del Prete, James E. Robinson, Michael R. Betts, David C. Montefiori, Celia C. LaBranche, and James A. Hoxie. Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus. J. Virol., 90(10):4966-4980, 15 May 2016. PubMed ID: 26937037. Show all entries for this paper.


Displaying record number 3811

Download this epitope record as JSON.

MAb ID 189D5
HXB2 Location SIV proteins SIV proteins Epitope Map
Author Location  
Epitope
Ab Type N-term
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain SIV
Vaccine component gp140

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Edinger2000 Aimee L. Edinger, Ména Ahuja, Tina Sung, Kelly C. Baxter, Beth Haggarty, Robert W. Doms, and James A. Hoxie. Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein. J. Virol., 74(17):7922-7935, Sep 2000. PubMed ID: 10933700. Show all entries for this paper.


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