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HIV Molecular Immunology Database

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Found 2 matching records:

Displaying record number 785

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MAb ID 1H5
HXB2 Location Env(578-612)
DNA(7956..8060)
Env Epitope Map
Author Location gp41(579-613 BH10)
Epitope ARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNA Epitope Alignment
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient  
Immunogen HIV-1 infection
Keywords antibody generation, review

Notes

Showing 2 of 2 notes.

References

Showing 3 of 3 references.

Isolation Paper
Buchacher1994 A. Buchacher, R. Predl, K. Strutzenberger, W. Steinfellner, A. Trkola, M. Purtscher, G. Gruber, C. Tauer, F. Steindl, A. Jungbauer, and H. Katinger. Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization. AIDS Res. Hum. Retroviruses, 10:359-369, 1994. A panel of 33 human monoclonal antibodies were produced. Linear epitopes for some of this set of MAbs were mapped using peptide ELISA. Linear epitopes were mapped in gp41, and a single epitope was mapped in p24. While multiple gp120 specific MAbs were generated, all seemed to be conformational or carbohydrate dependent, or both. PubMed ID: 7520721. Show all entries for this paper.

Buchacher1992 Andrea Buchacher, Renate Predl, Christa Tauer, Martin Purtscher, Gerhard Gruber, Renate Heider, Fraz Steindl, Alexandra Trkola, Alois Jungbauer, and Herman Katinger. Human Monoclonal Antibodies against gp41 and gp120 as Potential Agent for Passive Immunization. Vaccines, 92:191-195, 1992. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.


Displaying record number 2679

Download this epitope record as JSON.

MAb ID Fab 1H5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp41 five-helix bundle (one CHR of six helix bundle missing)
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords antibody generation, binding affinity, mimics

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Liu2011d Yanyun Liu, Lauren K. Regula, Alex Stewart, and Jonathan R. Lai. Synthetic Fab Fragments That Bind the HIV-1 gp41 Heptad Repeat Regions. Biochem. Biophys. Res. Commun., 413(4):611-605, 7 Oct 2011. PubMed ID: 21925149. Show all entries for this paper.


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