logo image

HIV Molecular Immunology Database

Search Antibody Database

Found 1 matching record:

Displaying record number 496

Download this epitope record as JSON.

MAb ID P4/D10 (P4D10)
HXB2 Location Env(309-316)
DNA(7149..7172)
Env Epitope Map
Author Location gp120
Epitope IxxGPGRA Epitope Alignment
IxxGPGRA epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1κ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type virus derived protein
Vaccine strain B clade IIIB
Vaccine component gp120

Notes

Showing 8 of 8 notes.

References

Showing 10 of 10 references.

Akerblom1990 L. Akerblom, J. Hinkula, P.-A. Broliden, B. Makitalo, T. Fridberger, J. Rosen, M. Villacres-Eriksson, B. Morein, and B. Wahren. Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gp120. AIDS, 4:953-960, 1990. PubMed ID: 1702001. Show all entries for this paper.

Broliden1990 P. A. Broliden, K. Ljunggren, J. Hinkula, E. Norrby, L. Akerblom, and B. Wahren. A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization. J. Virol., 64:936-940, 1990. PubMed ID: 2296090. Show all entries for this paper.

Broliden1991 P. A. Broliden, B. Makitalo, L. Akerblom, J. Rosen, K. Broliden, G. Utter, M. Jondal, E. Norrby, and B. Wahren. Identification of Amino Acids in the V3 Region of gp120 Critical for Virus Neutralization by Human HIV-1 Specific Antibodies. Immunology, 73:371-376, 1991. PubMed ID: 1916888. Show all entries for this paper.

Marks1991 J. D. Marks, B. Wahren, G. Gilljam, J. Hinkula, and G. Winter. Cloning of an HIV-1 Neutralizing V3 Specific Monoclonal Antibody and Expression as a Mouse-Human Chimaeric Antigen Binding Fragment and Antibody. J. Acquir. Immune Defic. Syndr., 1991:1162, 1992. Aidsline: 1116291Abstract: VIIth International Conference on AIDS, Florence, Italy, proceedings. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.

Arendrup1993 M. Arendrup, A. Sonnerborg, B. Svennerholm, L. Akerblom, C. Nielsen, H. Clausen, S. Olofsson, J. O. Nielsen, and J. E. S. Hensen. Neutralizing antibody response during human immunodeficiency virus type 1 infection: type and group specificity and viral escape. J. Gen. Virol., 74:855-863, 1993. PubMed ID: 7684062. Show all entries for this paper.

Hinkula1994 J. Hinkula, G. Bratt, G. Gilljam, S. Nordlund, P.A. Broliden, V. Holmberg, E. Olausson-Hansson, J. Albert, E. Sandstrom, and B. Wahren. Immunological and Virological Interaction in Patients Receiving Passive Immunotherapy with HIV-1 neutralizing monoclonal antibodies. J. Acquir. Immune Defic. Syndr., 7:940-951, 1994. Eleven HIV-1 infected patients in the late stages were treated with mouse MAbs that showed high HIV-1 neutralization. The amount of p24 in the sera of patients decreased in five patients, but remained the same or increased in six of them. The level of viral RNA in the plasma of patients decreased in four, showed no changes in another four and increased in the other three. By themselves, the MAbs did not appear to be efficient enough to decrease the virus burden in a permanent form in late-stage HIV patients. PubMed ID: 8051620. Show all entries for this paper.

Jacobson1998 J. M. Jacobson. Passive Immunization for the Treatment of HIV Infection. Mt. Sinai J. Med., 65:22-26, 1998. Review. PubMed ID: 9458680. Show all entries for this paper.

Schonning1998 K. Schonning, A. Bolmstedt, J. Novotny, O. S. Lund, S. Olofsson, and J. E. Hansen. Induction of Antibodies against Epitopes Inaccessible on the HIV Type 1 Envelope Oligomer by Immunization with Recombinant Monomeric Glycoprotein 120. AIDS Res. Hum. Retroviruses, 14:1451-1456, 1998. PubMed ID: 9824323. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.


This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.

Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Copyright Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services LANL logo National Institutes of Health logo