Found 1 matching record:
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MAb ID | 10/54 (10/54ow/6i/6i) | |
---|---|---|
HXB2 Location | Env(311-321) DNA(7155..7187) |
Env Epitope Map |
Author Location | gp120(311-321 HXB10) | |
Epitope |
RGPGRAFVTIG
|
Epitope Alignment
|
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | L (HXB10) | |
Species (Isotype) | rat(IgG1) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade BH10 |
Vaccine component | gp120 |
Showing 3 of 3 notes.
Showing 4 of 4 references.
McKeating1992a J. A. McKeating, J. Cordell, C. J. Dean, and P. Balfe. Synergistic Interaction between Ligands Binding to the CD4 Binding Site and V3 Domain of Human Immunodeficiency Virus Type I gp120. Virology, 191:732-742, 1992. PubMed ID: 1280382. Show all entries for this paper.
McKeating1993b J. A. McKeating, J. Bennett, S. Zolla-Pazner, M. Schutten, S. Ashelford, A. Leigh-Brown, and P. Balfe. Resistance of a Human Serum-Selected Human Immunodeficiency Virus Type 1 Escape Mutant to Neutralization by CD4 Binding Site Monoclonal Antibodies Is Conferred by a Single Amino Acid Change in gp120. J. Virol., 67:5216-5225, 1993. PubMed ID: 7688820. Show all entries for this paper.
McKeating1993a J. A. McKeating, C. Shotton, J. Cordell, S. Graham, P. Balfe, N. Sullivan, M. Charles, M. Page, A. Bolmstedt, S. Olofsson, S. C. Kayman, Z. Wu, A. Pinter, C. Dean, J. Sodroski, and R. A. Weiss. Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120. J. Virol., 67:4932-4944, 1993. Substitutions in the V2 loop can result in complete dissociation of gp120 and gp41, suggesting alterations in V2 can affect subunit assembly. Other substitutions allowed gp120-gp41 association and expression, but inhibited viral entry or syncytia. Binding of some neutralizing MAbs was altered by V2 substitutions. For MAb CRA-4, changes at residues 191/192/193 (YSL/GSS), and for 11/68b, changes at residues 183/184 (PI/SG), within V2, and for both MAbs a position 435 (Y/H) change in C4, abrogate binding. These MAbs can bind to V1 and V2 domains in the absence of C4 domain, so the C4 substitution probably results in conformational change. PubMed ID: 7687306. Show all entries for this paper.
Peet1998 N. M. Peet, J. A. McKeating, J. B. de Souza, I. M. Roitt, P. J. Delves, and T. Lund. The Effect of Low-Profile Serine Substitutions in the V3 Loop of HIV-1. Virology, 251:59-70, 1998. PubMed ID: 9813203. Show all entries for this paper.
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